Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103431 https://doi.org/10.1007/s40123-021-00437-z |
Resumo: | Introduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT\6 and increased CRT) and C (MAT C 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p\0.001) and increased foveal avascular zone (FAZ) area (p\0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer ? inner plexiform layer (GCL ? IPL) was present in both phenotypes. Whenanalyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL ? IPL thinning (p\0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level. |
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7160 |
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Characterization of One-Year Progression of Risk Phenotypes of Diabetic RetinopathyDiabetesRetinopathyCapillary closureNeurodegenerationIntroduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT\6 and increased CRT) and C (MAT C 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p\0.001) and increased foveal avascular zone (FAZ) area (p\0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer ? inner plexiform layer (GCL ? IPL) was present in both phenotypes. Whenanalyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL ? IPL thinning (p\0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level.Adis2022-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103431http://hdl.handle.net/10316/103431https://doi.org/10.1007/s40123-021-00437-zeng2193-824534865186Ribeiro, LuísaMarques, Inês P.Coimbra, RitaSantos, TorcatoMadeira, Maria H.Santos, Ana RitaBarreto, Patrícia Susana Correia LopesLobo, ConceiçãoVaz, José Guilherme Fernandes da Cunhainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-11T21:40:58Zoai:estudogeral.uc.pt:10316/103431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:16.131353Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
title |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
spellingShingle |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy Ribeiro, Luísa Diabetes Retinopathy Capillary closure Neurodegeneration |
title_short |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
title_full |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
title_fullStr |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
title_full_unstemmed |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
title_sort |
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy |
author |
Ribeiro, Luísa |
author_facet |
Ribeiro, Luísa Marques, Inês P. Coimbra, Rita Santos, Torcato Madeira, Maria H. Santos, Ana Rita Barreto, Patrícia Susana Correia Lopes Lobo, Conceição Vaz, José Guilherme Fernandes da Cunha |
author_role |
author |
author2 |
Marques, Inês P. Coimbra, Rita Santos, Torcato Madeira, Maria H. Santos, Ana Rita Barreto, Patrícia Susana Correia Lopes Lobo, Conceição Vaz, José Guilherme Fernandes da Cunha |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro, Luísa Marques, Inês P. Coimbra, Rita Santos, Torcato Madeira, Maria H. Santos, Ana Rita Barreto, Patrícia Susana Correia Lopes Lobo, Conceição Vaz, José Guilherme Fernandes da Cunha |
dc.subject.por.fl_str_mv |
Diabetes Retinopathy Capillary closure Neurodegeneration |
topic |
Diabetes Retinopathy Capillary closure Neurodegeneration |
description |
Introduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT\6 and increased CRT) and C (MAT C 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p\0.001) and increased foveal avascular zone (FAZ) area (p\0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer ? inner plexiform layer (GCL ? IPL) was present in both phenotypes. Whenanalyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL ? IPL thinning (p\0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103431 http://hdl.handle.net/10316/103431 https://doi.org/10.1007/s40123-021-00437-z |
url |
http://hdl.handle.net/10316/103431 https://doi.org/10.1007/s40123-021-00437-z |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2193-8245 34865186 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Adis |
publisher.none.fl_str_mv |
Adis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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