Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Luísa
Data de Publicação: 2022
Outros Autores: Marques, Inês P., Coimbra, Rita, Santos, Torcato, Madeira, Maria H., Santos, Ana Rita, Barreto, Patrícia Susana Correia Lopes, Lobo, Conceição, Vaz, José Guilherme Fernandes da Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/103431
https://doi.org/10.1007/s40123-021-00437-z
Resumo: Introduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT\6 and increased CRT) and C (MAT C 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p\0.001) and increased foveal avascular zone (FAZ) area (p\0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer ? inner plexiform layer (GCL ? IPL) was present in both phenotypes. Whenanalyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL ? IPL thinning (p\0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level.
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spelling Characterization of One-Year Progression of Risk Phenotypes of Diabetic RetinopathyDiabetesRetinopathyCapillary closureNeurodegenerationIntroduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT\6 and increased CRT) and C (MAT C 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p\0.001) and increased foveal avascular zone (FAZ) area (p\0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer ? inner plexiform layer (GCL ? IPL) was present in both phenotypes. Whenanalyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL ? IPL thinning (p\0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level.Adis2022-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103431http://hdl.handle.net/10316/103431https://doi.org/10.1007/s40123-021-00437-zeng2193-824534865186Ribeiro, LuísaMarques, Inês P.Coimbra, RitaSantos, TorcatoMadeira, Maria H.Santos, Ana RitaBarreto, Patrícia Susana Correia LopesLobo, ConceiçãoVaz, José Guilherme Fernandes da Cunhainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-11T21:40:58Zoai:estudogeral.uc.pt:10316/103431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:16.131353Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
title Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
spellingShingle Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
Ribeiro, Luísa
Diabetes
Retinopathy
Capillary closure
Neurodegeneration
title_short Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
title_full Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
title_fullStr Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
title_full_unstemmed Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
title_sort Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
author Ribeiro, Luísa
author_facet Ribeiro, Luísa
Marques, Inês P.
Coimbra, Rita
Santos, Torcato
Madeira, Maria H.
Santos, Ana Rita
Barreto, Patrícia Susana Correia Lopes
Lobo, Conceição
Vaz, José Guilherme Fernandes da Cunha
author_role author
author2 Marques, Inês P.
Coimbra, Rita
Santos, Torcato
Madeira, Maria H.
Santos, Ana Rita
Barreto, Patrícia Susana Correia Lopes
Lobo, Conceição
Vaz, José Guilherme Fernandes da Cunha
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Luísa
Marques, Inês P.
Coimbra, Rita
Santos, Torcato
Madeira, Maria H.
Santos, Ana Rita
Barreto, Patrícia Susana Correia Lopes
Lobo, Conceição
Vaz, José Guilherme Fernandes da Cunha
dc.subject.por.fl_str_mv Diabetes
Retinopathy
Capillary closure
Neurodegeneration
topic Diabetes
Retinopathy
Capillary closure
Neurodegeneration
description Introduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT\6 and increased CRT) and C (MAT C 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p\0.001) and increased foveal avascular zone (FAZ) area (p\0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer ? inner plexiform layer (GCL ? IPL) was present in both phenotypes. Whenanalyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL ? IPL thinning (p\0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103431
http://hdl.handle.net/10316/103431
https://doi.org/10.1007/s40123-021-00437-z
url http://hdl.handle.net/10316/103431
https://doi.org/10.1007/s40123-021-00437-z
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 2193-8245
34865186
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