Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/13290 |
Resumo: | Near infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomaterials for cancer chemophotodynamic/photothermal therapy is a complex process. First, nanomaterials with photothermal capacity are synthesized, being then loaded with photosensitizers plus chemotherapeutics, and, finally functionalized with polymers for achieving suitable biological properties. To overcome this limitation, in this work, a novel straightforward approach to attain NIR light-responsive nanosystems for cancer chemo-photodynamic/ photothermal therapy was established. Such was accomplished by synthesizing poly(2-ethyl-2-oxazoline)- IR780 amphiphilic conjugates, which can be assembled into nanoparticles with photodynamic/photothermal capabilities that simultaneously encapsulate Doxorubicin (DOX/PEtOx-IR NPs). The DOX/PEtOx-IR NPs presented a suitable size and surface charge for cancer-related applications. When irradiated with NIR light, the DOX/PEtOx-IR NPs produced singlet oxygen as well as a smaller thermic effect that boosted the release of DOX by 1.7-times. In the in vitro studies, the combination of DOX/PEtOx-IR NPs and NIR light could completely ablate breast cancer cells (viability ≈ 4 %), demonstrating the enhanced outcome arising from the nanomaterials' chemo-photodynamic/photothermal therapy. |
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Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTTCombinatorial triple therapyLight responsive nanoparticlesMultifunctional nanomaterialsPhotodynamic therapyPoly(2-ethyl-2-oxazoline)Polymer-IR780 conjugateNear infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomaterials for cancer chemophotodynamic/photothermal therapy is a complex process. First, nanomaterials with photothermal capacity are synthesized, being then loaded with photosensitizers plus chemotherapeutics, and, finally functionalized with polymers for achieving suitable biological properties. To overcome this limitation, in this work, a novel straightforward approach to attain NIR light-responsive nanosystems for cancer chemo-photodynamic/ photothermal therapy was established. Such was accomplished by synthesizing poly(2-ethyl-2-oxazoline)- IR780 amphiphilic conjugates, which can be assembled into nanoparticles with photodynamic/photothermal capabilities that simultaneously encapsulate Doxorubicin (DOX/PEtOx-IR NPs). The DOX/PEtOx-IR NPs presented a suitable size and surface charge for cancer-related applications. When irradiated with NIR light, the DOX/PEtOx-IR NPs produced singlet oxygen as well as a smaller thermic effect that boosted the release of DOX by 1.7-times. In the in vitro studies, the combination of DOX/PEtOx-IR NPs and NIR light could completely ablate breast cancer cells (viability ≈ 4 %), demonstrating the enhanced outcome arising from the nanomaterials' chemo-photodynamic/photothermal therapy.ElsevieruBibliorumNave, MicaelaCosta, Francisco J. P.Alves, CátiaSousa, Rita LimaMelo, Bruna L.Correia, I.J.Diogo, Duarte de Melo2023-01-142025-04-04T00:00:00Z2023-01-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/13290eng10.1016/j.ejpb.2023.01.009info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:56:47Zoai:ubibliorum.ubi.pt:10400.6/13290Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:52:45.040487Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
title |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
spellingShingle |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT Nave, Micaela Combinatorial triple therapy Light responsive nanoparticles Multifunctional nanomaterials Photodynamic therapy Poly(2-ethyl-2-oxazoline) Polymer-IR780 conjugate |
title_short |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
title_full |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
title_fullStr |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
title_full_unstemmed |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
title_sort |
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT |
author |
Nave, Micaela |
author_facet |
Nave, Micaela Costa, Francisco J. P. Alves, Cátia Sousa, Rita Lima Melo, Bruna L. Correia, I.J. Diogo, Duarte de Melo |
author_role |
author |
author2 |
Costa, Francisco J. P. Alves, Cátia Sousa, Rita Lima Melo, Bruna L. Correia, I.J. Diogo, Duarte de Melo |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Nave, Micaela Costa, Francisco J. P. Alves, Cátia Sousa, Rita Lima Melo, Bruna L. Correia, I.J. Diogo, Duarte de Melo |
dc.subject.por.fl_str_mv |
Combinatorial triple therapy Light responsive nanoparticles Multifunctional nanomaterials Photodynamic therapy Poly(2-ethyl-2-oxazoline) Polymer-IR780 conjugate |
topic |
Combinatorial triple therapy Light responsive nanoparticles Multifunctional nanomaterials Photodynamic therapy Poly(2-ethyl-2-oxazoline) Polymer-IR780 conjugate |
description |
Near infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomaterials for cancer chemophotodynamic/photothermal therapy is a complex process. First, nanomaterials with photothermal capacity are synthesized, being then loaded with photosensitizers plus chemotherapeutics, and, finally functionalized with polymers for achieving suitable biological properties. To overcome this limitation, in this work, a novel straightforward approach to attain NIR light-responsive nanosystems for cancer chemo-photodynamic/ photothermal therapy was established. Such was accomplished by synthesizing poly(2-ethyl-2-oxazoline)- IR780 amphiphilic conjugates, which can be assembled into nanoparticles with photodynamic/photothermal capabilities that simultaneously encapsulate Doxorubicin (DOX/PEtOx-IR NPs). The DOX/PEtOx-IR NPs presented a suitable size and surface charge for cancer-related applications. When irradiated with NIR light, the DOX/PEtOx-IR NPs produced singlet oxygen as well as a smaller thermic effect that boosted the release of DOX by 1.7-times. In the in vitro studies, the combination of DOX/PEtOx-IR NPs and NIR light could completely ablate breast cancer cells (viability ≈ 4 %), demonstrating the enhanced outcome arising from the nanomaterials' chemo-photodynamic/photothermal therapy. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-14 2023-01-14T00:00:00Z 2025-04-04T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/13290 |
url |
http://hdl.handle.net/10400.6/13290 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.ejpb.2023.01.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136415854886912 |