Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds

• Autor(a) principal: Sharifi-Rad, J
• Data de Publicação: 2020
• Outros Autores: Rodrigues, CF, Sharopov, F, Docea, AO, Karaca, AC, Sharifi-Rad, M, Karincaoglu, DK, Gülseren, G, Senol, E, Demircan, E, Taheri, Y, Suleria, HAR, Özçelik, B, Kasapoglu, KN, Gültekin-Özgüven, M, Daskaya-Dikmen, C, Cho, WC, Martins, N, Calina, D
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/10216/142507

Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.