Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients

Detalhes bibliográficos
Autor(a) principal: Ferreira, AC
Data de Publicação: 2011
Outros Autores: Carvalho, D, Carvalho, F, Galvão, MJ, Nolasco, F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3013
Resumo: BACKGROUND: Collapsing glomerulopathy (CG) is a glomerulonephritis seen in association with human immunodeficiency virus (HIV) infection, known as HIV-associated nephropathy (HIVAN), and less frequently observed in non-HIV-infected patients. Method. The aim of this study was to review the histological and clinical findings of all CG diagnosed since 1981 in our laboratory. Result. Since 1981, 18 kidney biopsies with collapsing features were diagnosed among 6130 biopsies performed: 72.2% (n = 13) males, mean age 33.8 ± 9.7 years, 61.1% (n = 11) of black ethnic origin. HIV infection was present in 10 patients. Mean serum creatinine (Scr) was 4.7 ± 2.5 mg/dL, and mean proteinuria was 6.1 ± 5 g/24 h. Both HIVAN and non-HIVAN patients were similar in terms of age, gender and dialysis requirement. In the HIVAN population, African origin was predominant and more frequent than in the non-HIVAN population, Scr was higher and proteinuria was less severe. Interstitial infiltrate, interstitial fibrosis and tubular atrophy were severe, and the presence of microcystic dilatation of renal tubules was more common. Immunofluorescence was positive in six patients. In the non-HIVAN population, this histological lesion was related to an infectious illness in 6/8 patients and to the use of illegal oral drugs in one patient. Interstitial infiltrate, interstitial fibrosis and tubular atrophy presented as moderate to severe, and tubular atrophy correlated with dialysis requirement. Mesangial proliferation was present in 3/8 patients, with C3 and IgA deposits. CONCLUSION: CG is a rare podocytopathy. In this study, the association between infection and CG is evident, and we may suggest that infections could, in a direct or indirect manner, be a trigger of podocyte injury.
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spelling Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV PatientsAdultFemaleFollow-Up StudiesGlomerulosclerosis, Focal SegmentalHIV InfectionsHIV-1HumansMaleRetrospective StudiesRisk FactorsSurvival RateHCC NEFBACKGROUND: Collapsing glomerulopathy (CG) is a glomerulonephritis seen in association with human immunodeficiency virus (HIV) infection, known as HIV-associated nephropathy (HIVAN), and less frequently observed in non-HIV-infected patients. Method. The aim of this study was to review the histological and clinical findings of all CG diagnosed since 1981 in our laboratory. Result. Since 1981, 18 kidney biopsies with collapsing features were diagnosed among 6130 biopsies performed: 72.2% (n = 13) males, mean age 33.8 ± 9.7 years, 61.1% (n = 11) of black ethnic origin. HIV infection was present in 10 patients. Mean serum creatinine (Scr) was 4.7 ± 2.5 mg/dL, and mean proteinuria was 6.1 ± 5 g/24 h. Both HIVAN and non-HIVAN patients were similar in terms of age, gender and dialysis requirement. In the HIVAN population, African origin was predominant and more frequent than in the non-HIVAN population, Scr was higher and proteinuria was less severe. Interstitial infiltrate, interstitial fibrosis and tubular atrophy were severe, and the presence of microcystic dilatation of renal tubules was more common. Immunofluorescence was positive in six patients. In the non-HIVAN population, this histological lesion was related to an infectious illness in 6/8 patients and to the use of illegal oral drugs in one patient. Interstitial infiltrate, interstitial fibrosis and tubular atrophy presented as moderate to severe, and tubular atrophy correlated with dialysis requirement. Mesangial proliferation was present in 3/8 patients, with C3 and IgA deposits. CONCLUSION: CG is a rare podocytopathy. In this study, the association between infection and CG is evident, and we may suggest that infections could, in a direct or indirect manner, be a trigger of podocyte injury.Oxford University PressRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEFerreira, ACCarvalho, DCarvalho, FGalvão, MJNolasco, F2018-08-06T15:22:16Z2011-072011-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3013engNephrol Dial Transplant. 2011 Jul;26(7):2209-15.10.1093/ndt/gfq686info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:49Zoai:repositorio.chlc.min-saude.pt:10400.17/3013Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:19.483339Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
title Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
spellingShingle Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
Ferreira, AC
Adult
Female
Follow-Up Studies
Glomerulosclerosis, Focal Segmental
HIV Infections
HIV-1
Humans
Male
Retrospective Studies
Risk Factors
Survival Rate
HCC NEF
title_short Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
title_full Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
title_fullStr Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
title_full_unstemmed Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
title_sort Collapsing Glomerulopathy in Portugal: a Review of the Histological and Clinical Findings in HIV and Non-HIV Patients
author Ferreira, AC
author_facet Ferreira, AC
Carvalho, D
Carvalho, F
Galvão, MJ
Nolasco, F
author_role author
author2 Carvalho, D
Carvalho, F
Galvão, MJ
Nolasco, F
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Ferreira, AC
Carvalho, D
Carvalho, F
Galvão, MJ
Nolasco, F
dc.subject.por.fl_str_mv Adult
Female
Follow-Up Studies
Glomerulosclerosis, Focal Segmental
HIV Infections
HIV-1
Humans
Male
Retrospective Studies
Risk Factors
Survival Rate
HCC NEF
topic Adult
Female
Follow-Up Studies
Glomerulosclerosis, Focal Segmental
HIV Infections
HIV-1
Humans
Male
Retrospective Studies
Risk Factors
Survival Rate
HCC NEF
description BACKGROUND: Collapsing glomerulopathy (CG) is a glomerulonephritis seen in association with human immunodeficiency virus (HIV) infection, known as HIV-associated nephropathy (HIVAN), and less frequently observed in non-HIV-infected patients. Method. The aim of this study was to review the histological and clinical findings of all CG diagnosed since 1981 in our laboratory. Result. Since 1981, 18 kidney biopsies with collapsing features were diagnosed among 6130 biopsies performed: 72.2% (n = 13) males, mean age 33.8 ± 9.7 years, 61.1% (n = 11) of black ethnic origin. HIV infection was present in 10 patients. Mean serum creatinine (Scr) was 4.7 ± 2.5 mg/dL, and mean proteinuria was 6.1 ± 5 g/24 h. Both HIVAN and non-HIVAN patients were similar in terms of age, gender and dialysis requirement. In the HIVAN population, African origin was predominant and more frequent than in the non-HIVAN population, Scr was higher and proteinuria was less severe. Interstitial infiltrate, interstitial fibrosis and tubular atrophy were severe, and the presence of microcystic dilatation of renal tubules was more common. Immunofluorescence was positive in six patients. In the non-HIVAN population, this histological lesion was related to an infectious illness in 6/8 patients and to the use of illegal oral drugs in one patient. Interstitial infiltrate, interstitial fibrosis and tubular atrophy presented as moderate to severe, and tubular atrophy correlated with dialysis requirement. Mesangial proliferation was present in 3/8 patients, with C3 and IgA deposits. CONCLUSION: CG is a rare podocytopathy. In this study, the association between infection and CG is evident, and we may suggest that infections could, in a direct or indirect manner, be a trigger of podocyte injury.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
2011-07-01T00:00:00Z
2018-08-06T15:22:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3013
url http://hdl.handle.net/10400.17/3013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nephrol Dial Transplant. 2011 Jul;26(7):2209-15.
10.1093/ndt/gfq686
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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