Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/80337 |
Resumo: | Altered retinal dopamine and ON-pathway activity may underlie myopia development. It has been shown that the stimulation of the blind spot with short-wavelength light increases the electroretinogram (ERG) b-wave amplitude of myopic eyes and may engage the retinal dopaminergic system. This study evaluated the impact of various durations of blind spot stimulation on the electrophysiological response of the myopic retina and their relationship to axial length. Six myopic individuals underwent three short-wavelength blue light blind spot stimulation protocols (10 s, 1 min, 10 min) using a virtual reality headset. As a control condition, no stimulation was shown for 1 min. The b-wave amplitude of the photopic full-field ERG was measured at baseline and 10, 20, 30, 40, 50, and 60 min after each condition. A significant increase in b-wave amplitude was observed for all stimulation protocols compared to the control. The peak b-wave amplitude was observed 20 min after the 1-min stimulation protocol and 60 min after the 10-min stimulation protocol. A significant positive correlation was found between axial length of the eye and percent change in b-wave amplitude for the 10-min stimulation protocol. A rapid and a delayed b-wave time course responses were observed following 1 min and 10 min of blind spot stimulation, respectively. Overall, these results indicate that light stimulation of the blind spot for various durations elevates ON-bipolar cell activity in the retina and as such is assumed to reduce the myopic response. These findings could have implications for future myopia treatment. |
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Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individualsCiências Naturais::Ciências FísicasScience & TechnologyAltered retinal dopamine and ON-pathway activity may underlie myopia development. It has been shown that the stimulation of the blind spot with short-wavelength light increases the electroretinogram (ERG) b-wave amplitude of myopic eyes and may engage the retinal dopaminergic system. This study evaluated the impact of various durations of blind spot stimulation on the electrophysiological response of the myopic retina and their relationship to axial length. Six myopic individuals underwent three short-wavelength blue light blind spot stimulation protocols (10 s, 1 min, 10 min) using a virtual reality headset. As a control condition, no stimulation was shown for 1 min. The b-wave amplitude of the photopic full-field ERG was measured at baseline and 10, 20, 30, 40, 50, and 60 min after each condition. A significant increase in b-wave amplitude was observed for all stimulation protocols compared to the control. The peak b-wave amplitude was observed 20 min after the 1-min stimulation protocol and 60 min after the 10-min stimulation protocol. A significant positive correlation was found between axial length of the eye and percent change in b-wave amplitude for the 10-min stimulation protocol. A rapid and a delayed b-wave time course responses were observed following 1 min and 10 min of blind spot stimulation, respectively. Overall, these results indicate that light stimulation of the blind spot for various durations elevates ON-bipolar cell activity in the retina and as such is assumed to reduce the myopic response. These findings could have implications for future myopia treatment.This work was supported by the Federal Ministry of Education and Research, Industrie-in-Klinik-Plattform Program BMBF, Germany (FKZ: 13GW0256). This project was also supported by the Portuguese Foundation for Science and Technology (FCT) PTDC/FIS-OPT/0677/2014, the Strategic Funding UID/FIS/04650/2013 at Center of Physics, UMinho, and predoctoral grant SFRH/BD/136684/2018 to AAS.Nature ResearchUniversidade do MinhoSchilling, TimAmorim-de-Sousa, AnaWong, Nikita A.Bahmani, HamedGonzález-Méijome, José ManuelFernandes, Paulo2022-03-212022-03-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80337engSchilling, T., Amorim-de-Sousa, A., A Wong, N. et al. Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals. Sci Rep 12, 4785 (2022). https://doi.org/10.1038/s41598-022-08319-52045-23222045-232210.1038/s41598-022-08319-535314724https://www.nature.com/articles/s41598-022-08319-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:14Zoai:repositorium.sdum.uminho.pt:1822/80337Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:09.054661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
title |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
spellingShingle |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals Schilling, Tim Ciências Naturais::Ciências Físicas Science & Technology |
title_short |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
title_full |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
title_fullStr |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
title_full_unstemmed |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
title_sort |
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals |
author |
Schilling, Tim |
author_facet |
Schilling, Tim Amorim-de-Sousa, Ana Wong, Nikita A. Bahmani, Hamed González-Méijome, José Manuel Fernandes, Paulo |
author_role |
author |
author2 |
Amorim-de-Sousa, Ana Wong, Nikita A. Bahmani, Hamed González-Méijome, José Manuel Fernandes, Paulo |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Schilling, Tim Amorim-de-Sousa, Ana Wong, Nikita A. Bahmani, Hamed González-Méijome, José Manuel Fernandes, Paulo |
dc.subject.por.fl_str_mv |
Ciências Naturais::Ciências Físicas Science & Technology |
topic |
Ciências Naturais::Ciências Físicas Science & Technology |
description |
Altered retinal dopamine and ON-pathway activity may underlie myopia development. It has been shown that the stimulation of the blind spot with short-wavelength light increases the electroretinogram (ERG) b-wave amplitude of myopic eyes and may engage the retinal dopaminergic system. This study evaluated the impact of various durations of blind spot stimulation on the electrophysiological response of the myopic retina and their relationship to axial length. Six myopic individuals underwent three short-wavelength blue light blind spot stimulation protocols (10 s, 1 min, 10 min) using a virtual reality headset. As a control condition, no stimulation was shown for 1 min. The b-wave amplitude of the photopic full-field ERG was measured at baseline and 10, 20, 30, 40, 50, and 60 min after each condition. A significant increase in b-wave amplitude was observed for all stimulation protocols compared to the control. The peak b-wave amplitude was observed 20 min after the 1-min stimulation protocol and 60 min after the 10-min stimulation protocol. A significant positive correlation was found between axial length of the eye and percent change in b-wave amplitude for the 10-min stimulation protocol. A rapid and a delayed b-wave time course responses were observed following 1 min and 10 min of blind spot stimulation, respectively. Overall, these results indicate that light stimulation of the blind spot for various durations elevates ON-bipolar cell activity in the retina and as such is assumed to reduce the myopic response. These findings could have implications for future myopia treatment. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-21 2022-03-21T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/80337 |
url |
https://hdl.handle.net/1822/80337 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Schilling, T., Amorim-de-Sousa, A., A Wong, N. et al. Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals. Sci Rep 12, 4785 (2022). https://doi.org/10.1038/s41598-022-08319-5 2045-2322 2045-2322 10.1038/s41598-022-08319-5 35314724 https://www.nature.com/articles/s41598-022-08319-5 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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