Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications

Detalhes bibliográficos
Autor(a) principal: Santos, Cecília I. A. V.
Data de Publicação: 2022
Outros Autores: Barros, Marisa C. F., Ribeiro, Ana C. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/103470
https://doi.org/10.3390/pr10040660
Resumo: Diffusion coefficients, D, for ethanol in supercritical carbon dioxide (scCO2) were measured in the temperature range 306.15–331.15 K and along the 10.5MPa isobar, using the Taylor dispersion technique. The obtained diffusivities ranged from 1.49 108 to 2.98 108 m2 s1, an order of magnitude higher than in usual liquids. The dependence of D on temperature and solvent density was examined. Various correlation models based in the hydrodynamic theory were assessed to estimate the diffusion coefficients, with reasonable results obtained for theWilke–Chang and Lai–Tan models.
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spelling Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applicationssupercritical CO2diffusion coefficientsethanolTaylor dispersionDiffusion coefficients, D, for ethanol in supercritical carbon dioxide (scCO2) were measured in the temperature range 306.15–331.15 K and along the 10.5MPa isobar, using the Taylor dispersion technique. The obtained diffusivities ranged from 1.49 108 to 2.98 108 m2 s1, an order of magnitude higher than in usual liquids. The dependence of D on temperature and solvent density was examined. Various correlation models based in the hydrodynamic theory were assessed to estimate the diffusion coefficients, with reasonable results obtained for theWilke–Chang and Lai–Tan models.MDPI2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103470http://hdl.handle.net/10316/103470https://doi.org/10.3390/pr10040660eng2227-9717Santos, Cecília I. A. V.Barros, Marisa C. F.Ribeiro, Ana C. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-15T21:35:52Zoai:estudogeral.uc.pt:10316/103470Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:18.029612Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
title Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
spellingShingle Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
Santos, Cecília I. A. V.
supercritical CO2
diffusion coefficients
ethanol
Taylor dispersion
title_short Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
title_full Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
title_fullStr Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
title_full_unstemmed Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
title_sort Diffusion of Ethanol in Supercritical Carbon Dioxide—Investigation of scCO2-Cosolvent Mixtures Used in Pharmaceutical Applications
author Santos, Cecília I. A. V.
author_facet Santos, Cecília I. A. V.
Barros, Marisa C. F.
Ribeiro, Ana C. F.
author_role author
author2 Barros, Marisa C. F.
Ribeiro, Ana C. F.
author2_role author
author
dc.contributor.author.fl_str_mv Santos, Cecília I. A. V.
Barros, Marisa C. F.
Ribeiro, Ana C. F.
dc.subject.por.fl_str_mv supercritical CO2
diffusion coefficients
ethanol
Taylor dispersion
topic supercritical CO2
diffusion coefficients
ethanol
Taylor dispersion
description Diffusion coefficients, D, for ethanol in supercritical carbon dioxide (scCO2) were measured in the temperature range 306.15–331.15 K and along the 10.5MPa isobar, using the Taylor dispersion technique. The obtained diffusivities ranged from 1.49 108 to 2.98 108 m2 s1, an order of magnitude higher than in usual liquids. The dependence of D on temperature and solvent density was examined. Various correlation models based in the hydrodynamic theory were assessed to estimate the diffusion coefficients, with reasonable results obtained for theWilke–Chang and Lai–Tan models.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103470
http://hdl.handle.net/10316/103470
https://doi.org/10.3390/pr10040660
url http://hdl.handle.net/10316/103470
https://doi.org/10.3390/pr10040660
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2227-9717
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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