Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community

Detalhes bibliográficos
Autor(a) principal: Jesus, Laura
Data de Publicação: 2022
Outros Autores: Arenas, Carolina, Dominguez-Ruiz, Marina, Silvestrini, Paolo, Englar, Ryane E., Roura, Xavier, Leal, Rodolfo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/25651
Resumo: Research Areas: Immunology ; Microbiology ; Veterinary Sciences
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spelling Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary communityCanineXanthineUrolithiasisKidneyLeishmaniaPortugalSpainResearch Areas: Immunology ; Microbiology ; Veterinary SciencesXanthinuria is a significant adverse effect in dogs on long-term allopurinol for treatment of leishmaniosis. The study aims to investigate how the Iberian veterinary community (IVC) identifies, manages, and proactively prevents xanthinuria secondary to allopurinol treatment. A cross-sectional study was conducted using an online survey, translated into two languages, and disseminated to the IVC via social networking forums. Respondents were asked to share their treatment regimens, adverse effects attributed to treatment, as well as preventive and reactive measures against xanthuria. Of two-hundred and thirty respondents, 99.6% prescribe allopurinol for canine leishmaniosis. Xanthinuria was estimated to happen in less than one out of every four dogs by 91.7% of the clinicians. Xanthinuria has been detected by 71.6% of respondents at least once. Three out of every four respondents inform owners about deleterious effects of allopurinol, and 28.4% consider implementing a change in diet in advance of treatment as a proactive measure. To monitor xanthinuria, urinalysis and diagnostic imaging are used by 71.2% and 31% of clinicians respectively. When xanthinuria is detected, 43.2% of the respondents discontinue allopurinol, 24% replace it by nucleotide-analogs, 14.9% reduce its dosage, and 3.1% split its dosage but increase administration frequency. Additional measures are taken by 72.1% of the respondents, 59.4% of whom prescribe a low-purine diet. The IVC recognizes xanthinuria as a fairly common secondary effect of long-term allopurinol treatment in dogs with leishmaniosis and recommends periodically monitoring and preventive measures.ElsevierRepositório da Universidade de LisboaJesus, LauraArenas, CarolinaDominguez-Ruiz, MarinaSilvestrini, PaoloEnglar, Ryane E.Roura, XavierLeal, Rodolfo2022-10-01T22:41:15Z2022-04-232022-04-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/25651engJesus L, Arenas C, Dominguez-Ruiz M, Silvestrini P, Englar RE, Roura X, Leal RO. 2022. Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: Current perspectives of the Iberian veterinary community. Comparative Immunology, Microbiology and Infectious Diseases, 83:101783. DOI: https://doi.org/10.1016/j.cimid.2022.1017830147-957110.1016/j.cimid.2022.1017831878-1667info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:55:12Zoai:www.repository.utl.pt:10400.5/25651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:09:27.729480Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
title Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
spellingShingle Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
Jesus, Laura
Canine
Xanthine
Urolithiasis
Kidney
Leishmania
Portugal
Spain
title_short Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
title_full Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
title_fullStr Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
title_full_unstemmed Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
title_sort Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: current perspectives of the Iberian veterinary community
author Jesus, Laura
author_facet Jesus, Laura
Arenas, Carolina
Dominguez-Ruiz, Marina
Silvestrini, Paolo
Englar, Ryane E.
Roura, Xavier
Leal, Rodolfo
author_role author
author2 Arenas, Carolina
Dominguez-Ruiz, Marina
Silvestrini, Paolo
Englar, Ryane E.
Roura, Xavier
Leal, Rodolfo
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Jesus, Laura
Arenas, Carolina
Dominguez-Ruiz, Marina
Silvestrini, Paolo
Englar, Ryane E.
Roura, Xavier
Leal, Rodolfo
dc.subject.por.fl_str_mv Canine
Xanthine
Urolithiasis
Kidney
Leishmania
Portugal
Spain
topic Canine
Xanthine
Urolithiasis
Kidney
Leishmania
Portugal
Spain
description Research Areas: Immunology ; Microbiology ; Veterinary Sciences
publishDate 2022
dc.date.none.fl_str_mv 2022-10-01T22:41:15Z
2022-04-23
2022-04-23T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/25651
url http://hdl.handle.net/10400.5/25651
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jesus L, Arenas C, Dominguez-Ruiz M, Silvestrini P, Englar RE, Roura X, Leal RO. 2022. Xanthinuria secondary to allopurinol treatment in dogs with leishmaniosis: Current perspectives of the Iberian veterinary community. Comparative Immunology, Microbiology and Infectious Diseases, 83:101783. DOI: https://doi.org/10.1016/j.cimid.2022.101783
0147-9571
10.1016/j.cimid.2022.101783
1878-1667
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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