Assessment of long-term remission in lupus nephritis patients

Detalhes bibliográficos
Autor(a) principal: Fernandes das Neves, Marisa
Data de Publicação: 2015
Outros Autores: Irlapati, Rajendra Vara Prasad, Isenberg, David
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/149783
Resumo: Publisher Copyright: © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
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spelling Assessment of long-term remission in lupus nephritis patientsA retrospective analysis over 30 yearsLupus flaresLupus remissionRenal biopsy in lupusSystemic lupus erythematosusRheumatologyPharmacology (medical)Publisher Copyright: © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.Objective. To review the likelihood of very long-term remission in patients with biopsy-proven LN attempting to identify good prognostic features. Methods. We reviewed patients with LN whose renal biopsies showed World Health Organization (WHO) classes III, IV and V and who had a follow-up of at least 5 years between 1973 and 2008. We analysed demographic, clinical, laboratory and therapeutic parameters comparing those patients with (group A) and without (group B) 5 year remission. Results. Of 191 LN patients followed, 105 patients met the strict inclusion criteria. Ninety-five patients were female. Mean age at diagnosis of lupus was 24.1 years (s.d. 10.7). ean age at diagnosis of LN was 28.4 years (s.d. 11.3). The mean duration of follow-up was 13.7 years (s.d. 14.1). Forty (38%) patients achieved 5 year remission, of whom 17 (16.2%) had remission for ≥15 years. The incidence of flares per year from 5 to 15 years was 7.9%; however, no flares were observed after 15 years of remission. The only distinguishing feature found in this study was the association of WHO class IV on kidney biopsy with LN progression (P = 0.03).Conclusion. Renal histology with WHO class IV predicted a poor long-term remission rate. Age, sex, ethnicity, serological parameters and treatment received did not predict long-term remission. Renal flares can occur up to 15 years after a patient has gone into remission.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNFernandes das Neves, MarisaIrlapati, Rajendra Vara PrasadIsenberg, David2023-02-27T22:21:23Z2015-05-052015-05-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://hdl.handle.net/10362/149783eng1462-0324PURE: 47545473https://doi.org/10.1093/rheumatology/kev003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:37Zoai:run.unl.pt:10362/149783Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:51.129066Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Assessment of long-term remission in lupus nephritis patients
A retrospective analysis over 30 years
title Assessment of long-term remission in lupus nephritis patients
spellingShingle Assessment of long-term remission in lupus nephritis patients
Fernandes das Neves, Marisa
Lupus flares
Lupus remission
Renal biopsy in lupus
Systemic lupus erythematosus
Rheumatology
Pharmacology (medical)
title_short Assessment of long-term remission in lupus nephritis patients
title_full Assessment of long-term remission in lupus nephritis patients
title_fullStr Assessment of long-term remission in lupus nephritis patients
title_full_unstemmed Assessment of long-term remission in lupus nephritis patients
title_sort Assessment of long-term remission in lupus nephritis patients
author Fernandes das Neves, Marisa
author_facet Fernandes das Neves, Marisa
Irlapati, Rajendra Vara Prasad
Isenberg, David
author_role author
author2 Irlapati, Rajendra Vara Prasad
Isenberg, David
author2_role author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Fernandes das Neves, Marisa
Irlapati, Rajendra Vara Prasad
Isenberg, David
dc.subject.por.fl_str_mv Lupus flares
Lupus remission
Renal biopsy in lupus
Systemic lupus erythematosus
Rheumatology
Pharmacology (medical)
topic Lupus flares
Lupus remission
Renal biopsy in lupus
Systemic lupus erythematosus
Rheumatology
Pharmacology (medical)
description Publisher Copyright: © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-05
2015-05-05T00:00:00Z
2023-02-27T22:21:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/149783
url http://hdl.handle.net/10362/149783
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1462-0324
PURE: 47545473
https://doi.org/10.1093/rheumatology/kev003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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