Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/55253 |
Resumo: | Candidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing. The goal of this work was to determine the susceptibility of C. glabrata biofilms to echinocandins and to evaluate their effect on the biofilm matrix composition, comparing the results with other Candida species. Drug susceptibilities were assessed through the determination of minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum biofilm eradication concentration (MBEC) of caspofungin (Csf) and micafugin (Mcf). The -1,3 glucans content of the matrices was assessed after contact with the drugs. The data suggest that, generally, after contact with echinocandins, the concentration of -1,3 glucans increased. These adjustments in the matrix composition of C. glabrata biofilms and the chemical differences between Csf and Mcf, seem responsible and may determine the effectivity of the drug responses. |
id |
RCAP_9f5aad3a971c7747d7bb78dae07a889e |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/55253 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix compositionCandida glabrataechinocandinbiofilmmatrixantifungal drugresistanceScience & TechnologyCandidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing. The goal of this work was to determine the susceptibility of C. glabrata biofilms to echinocandins and to evaluate their effect on the biofilm matrix composition, comparing the results with other Candida species. Drug susceptibilities were assessed through the determination of minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum biofilm eradication concentration (MBEC) of caspofungin (Csf) and micafugin (Mcf). The -1,3 glucans content of the matrices was assessed after contact with the drugs. The data suggest that, generally, after contact with echinocandins, the concentration of -1,3 glucans increased. These adjustments in the matrix composition of C. glabrata biofilms and the chemical differences between Csf and Mcf, seem responsible and may determine the effectivity of the drug responses.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 [POCI-01–0145-FEDER-006684] and BioTecNorte operation [NORTE-01–0145-FEDER-000004] funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte, Célia F. Rodrigues’ [SFRH/BD/93078/2013] PhD grant and M. Elisa Rodrigues [SFRH/BPD/95401/2013] post-doctoral grant.info:eu-repo/semantics/publishedVersionTaylor and FrancisUniversidade do MinhoRodrigues, Célia FortunaRodrigues, M. Elisa.Henriques, Mariana20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/55253engRodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition. Biofouling - The Journal of Bioadhesion and Biofilm Research, 34(5), 569-578, 20180892-70141029-245410.1080/08927014.2018.147224429798695http://www.tandfonline.com/action/journalInformation?journalCode=gbif20info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:46Zoai:repositorium.sdum.uminho.pt:1822/55253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:26:00.811938Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
title |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
spellingShingle |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition Rodrigues, Célia Fortuna Candida glabrata echinocandin biofilm matrix antifungal drug resistance Science & Technology |
title_short |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
title_full |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
title_fullStr |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
title_full_unstemmed |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
title_sort |
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
author |
Rodrigues, Célia Fortuna |
author_facet |
Rodrigues, Célia Fortuna Rodrigues, M. Elisa. Henriques, Mariana |
author_role |
author |
author2 |
Rodrigues, M. Elisa. Henriques, Mariana |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rodrigues, Célia Fortuna Rodrigues, M. Elisa. Henriques, Mariana |
dc.subject.por.fl_str_mv |
Candida glabrata echinocandin biofilm matrix antifungal drug resistance Science & Technology |
topic |
Candida glabrata echinocandin biofilm matrix antifungal drug resistance Science & Technology |
description |
Candidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing. The goal of this work was to determine the susceptibility of C. glabrata biofilms to echinocandins and to evaluate their effect on the biofilm matrix composition, comparing the results with other Candida species. Drug susceptibilities were assessed through the determination of minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum biofilm eradication concentration (MBEC) of caspofungin (Csf) and micafugin (Mcf). The -1,3 glucans content of the matrices was assessed after contact with the drugs. The data suggest that, generally, after contact with echinocandins, the concentration of -1,3 glucans increased. These adjustments in the matrix composition of C. glabrata biofilms and the chemical differences between Csf and Mcf, seem responsible and may determine the effectivity of the drug responses. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/55253 |
url |
http://hdl.handle.net/1822/55253 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition. Biofouling - The Journal of Bioadhesion and Biofilm Research, 34(5), 569-578, 2018 0892-7014 1029-2454 10.1080/08927014.2018.1472244 29798695 http://www.tandfonline.com/action/journalInformation?journalCode=gbif20 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor and Francis |
publisher.none.fl_str_mv |
Taylor and Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132746459643904 |