Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis

Detalhes bibliográficos
Autor(a) principal: Pereira da Silva, JA
Data de Publicação: 2002
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/206
Resumo: Gender and sex hormones are strongly related to the incidence and progression of autoimmune rheumatic diseases. Although sex steroids have been shown to have direct effects on the immune system, their influence in vivo may be mediated via interactions with third party systems including the hypothalamic-pituitary-adrenal axis. Such interactions are well demonstrated in experimental animals. In humans, there is increasing, although indirect, evidence that these interactions also occur. Possible interactions at the cell and gene level, with mutual antagonism or synergy between cortico- and gonadal steroids, open new exciting hypotheses that await clarification.
id RCAP_a0209709e4cf8112a515f9b8f1499514
oai_identifier_str oai:rihuc.huc.min-saude.pt:10400.4/206
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritisArtrite ReumatóideGlucocorticóidesGender and sex hormones are strongly related to the incidence and progression of autoimmune rheumatic diseases. Although sex steroids have been shown to have direct effects on the immune system, their influence in vivo may be mediated via interactions with third party systems including the hypothalamic-pituitary-adrenal axis. Such interactions are well demonstrated in experimental animals. In humans, there is increasing, although indirect, evidence that these interactions also occur. Possible interactions at the cell and gene level, with mutual antagonism or synergy between cortico- and gonadal steroids, open new exciting hypotheses that await clarification.RIHUCPereira da Silva, JA2008-11-27T16:28:17Z20022002-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/206engAnn N Y Acad Sci. 2002 Jun;966:158-65info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:21:21Zoai:rihuc.huc.min-saude.pt:10400.4/206Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:03.019880Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
title Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
spellingShingle Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
Pereira da Silva, JA
Artrite Reumatóide
Glucocorticóides
title_short Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
title_full Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
title_fullStr Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
title_full_unstemmed Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
title_sort Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis
author Pereira da Silva, JA
author_facet Pereira da Silva, JA
author_role author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Pereira da Silva, JA
dc.subject.por.fl_str_mv Artrite Reumatóide
Glucocorticóides
topic Artrite Reumatóide
Glucocorticóides
description Gender and sex hormones are strongly related to the incidence and progression of autoimmune rheumatic diseases. Although sex steroids have been shown to have direct effects on the immune system, their influence in vivo may be mediated via interactions with third party systems including the hypothalamic-pituitary-adrenal axis. Such interactions are well demonstrated in experimental animals. In humans, there is increasing, although indirect, evidence that these interactions also occur. Possible interactions at the cell and gene level, with mutual antagonism or synergy between cortico- and gonadal steroids, open new exciting hypotheses that await clarification.
publishDate 2002
dc.date.none.fl_str_mv 2002
2002-01-01T00:00:00Z
2008-11-27T16:28:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/206
url http://hdl.handle.net/10400.4/206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ann N Y Acad Sci. 2002 Jun;966:158-65
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1817554337192214529

Registros relacionados