Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii

Detalhes bibliográficos
Autor(a) principal: Delgado, Inês
Data de Publicação: 2024
Outros Autores: Gonçalves, João, Fernandes, Rita, Zúquete, Sara, Basto, Afonso P., Leitão, Alexandre, Soares, Helena, Nolasco, Sofia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/17232
Resumo: This research was funded by FCT-Fundação para a Ciência e Tecnologia, I.P. (Portugal) through CIISA - Centro de Investigação Interdisciplinar em Sanidade Animal, project UIDB/00276/2020 and Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS) project LA/P/0059/2020.
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spelling Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondiiToxoplasma gondiiApical complexMicrotubulesTubulin glutamylationTubulin post-translational modificationsThis research was funded by FCT-Fundação para a Ciência e Tecnologia, I.P. (Portugal) through CIISA - Centro de Investigação Interdisciplinar em Sanidade Animal, project UIDB/00276/2020 and Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS) project LA/P/0059/2020.The success of the intracellular parasite Toxoplasma gondii in invading host cells relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The T. gondii genome encodes three isoforms of both α- and β-tubulin, which undergo specific post-translational modifications (PTMs), altering the biochemical and biophysical proprieties of microtubules and modulating their interaction with associated proteins. Tubulin PTMs represent a powerful and evolutionarily conserved mechanism for generating tubulin diversity, forming a biochemical 'tubulin code' interpretable by microtubule-interacting factors. T. gondii exhibits various tubulin PTMs, including α-tubulin acetylation, α-tubulin detyrosination, Δ5α-tubulin, Δ2α-tubulin, α- and β-tubulin polyglutamylation, and α- and β-tubulin methylation. Tubulin glutamylation emerges as a key player in microtubule remodeling in Toxoplasma, regulating stability, dynamics, interaction with motor proteins, and severing enzymes. The balance of tubulin glutamylation is maintained through the coordinated action of polyglutamylases and deglutamylating enzymes. This work reviews and discusses current knowledge on T. gondii tubulin glutamylation. Through in silico identification of protein orthologs, we update the recognition of putative proteins related to glutamylation, contributing to a deeper understanding of its role in T. gondii biology.MDPIRCIPLDelgado, InêsGonçalves, JoãoFernandes, RitaZúquete, SaraBasto, Afonso P.Leitão, AlexandreSoares, HelenaNolasco, Sofia2024-04-01T10:24:53Z2024-022024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/17232engDelgado IL, Gonçalves J, Fernandes R, Zúquete S, Soares H, Nolasco S, et al. Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii. Microorganisms. 2024;12(3):488.10.3390/microorganisms12030488info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-04-03T02:15:47Zoai:repositorio.ipl.pt:10400.21/17232Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-04-03T02:15:47Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
title Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
spellingShingle Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
Delgado, Inês
Toxoplasma gondii
Apical complex
Microtubules
Tubulin glutamylation
Tubulin post-translational modifications
title_short Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
title_full Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
title_fullStr Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
title_full_unstemmed Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
title_sort Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
author Delgado, Inês
author_facet Delgado, Inês
Gonçalves, João
Fernandes, Rita
Zúquete, Sara
Basto, Afonso P.
Leitão, Alexandre
Soares, Helena
Nolasco, Sofia
author_role author
author2 Gonçalves, João
Fernandes, Rita
Zúquete, Sara
Basto, Afonso P.
Leitão, Alexandre
Soares, Helena
Nolasco, Sofia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Delgado, Inês
Gonçalves, João
Fernandes, Rita
Zúquete, Sara
Basto, Afonso P.
Leitão, Alexandre
Soares, Helena
Nolasco, Sofia
dc.subject.por.fl_str_mv Toxoplasma gondii
Apical complex
Microtubules
Tubulin glutamylation
Tubulin post-translational modifications
topic Toxoplasma gondii
Apical complex
Microtubules
Tubulin glutamylation
Tubulin post-translational modifications
description This research was funded by FCT-Fundação para a Ciência e Tecnologia, I.P. (Portugal) through CIISA - Centro de Investigação Interdisciplinar em Sanidade Animal, project UIDB/00276/2020 and Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS) project LA/P/0059/2020.
publishDate 2024
dc.date.none.fl_str_mv 2024-04-01T10:24:53Z
2024-02
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/17232
url http://hdl.handle.net/10400.21/17232
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Delgado IL, Gonçalves J, Fernandes R, Zúquete S, Soares H, Nolasco S, et al. Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii. Microorganisms. 2024;12(3):488.
10.3390/microorganisms12030488
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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