Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Detalhes bibliográficos
Autor(a) principal: Santos,Cátia
Data de Publicação: 2022
Outros Autores: Dixe,Maria dos Anjos, Sacadura-Leite,Ema, Astoul,Philippe, Sousa-Uva,António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2504-31452022000300188
Resumo: Abstract Background: The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM. Objective: This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM. Methods: A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed. Results: 3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients. Conclusion: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.
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spelling Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of LiteratureAsbestosExposureMalignant pleural mesotheliomaMortalityAbstract Background: The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM. Objective: This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM. Methods: A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed. Results: 3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients. Conclusion: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.Escola Nacional de Saúde Pública2022-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2504-31452022000300188Portuguese Journal of Public Health v.40 n.3 2022reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2504-31452022000300188Santos,CátiaDixe,Maria dos AnjosSacadura-Leite,EmaAstoul,PhilippeSousa-Uva,Antónioinfo:eu-repo/semantics/openAccess2024-02-06T17:34:35Zoai:scielo:S2504-31452022000300188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:36:30.412998Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
title Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
spellingShingle Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
Santos,Cátia
Asbestos
Exposure
Malignant pleural mesothelioma
Mortality
title_short Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
title_full Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
title_fullStr Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
title_full_unstemmed Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
title_sort Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
author Santos,Cátia
author_facet Santos,Cátia
Dixe,Maria dos Anjos
Sacadura-Leite,Ema
Astoul,Philippe
Sousa-Uva,António
author_role author
author2 Dixe,Maria dos Anjos
Sacadura-Leite,Ema
Astoul,Philippe
Sousa-Uva,António
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos,Cátia
Dixe,Maria dos Anjos
Sacadura-Leite,Ema
Astoul,Philippe
Sousa-Uva,António
dc.subject.por.fl_str_mv Asbestos
Exposure
Malignant pleural mesothelioma
Mortality
topic Asbestos
Exposure
Malignant pleural mesothelioma
Mortality
description Abstract Background: The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM. Objective: This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM. Methods: A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed. Results: 3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients. Conclusion: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.
publishDate 2022
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dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública
publisher.none.fl_str_mv Escola Nacional de Saúde Pública
dc.source.none.fl_str_mv Portuguese Journal of Public Health v.40 n.3 2022
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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