Wettability influences cell behavior on superhydrophobic surfaces with different topographies

Detalhes bibliográficos
Autor(a) principal: Lourenço, Bianca do Nascimento
Data de Publicação: 2012
Outros Autores: Marchioli, Giulia, Welong Song, Reis, R. L., Blitterswijk, C. A. van, Karperien, Marcel, Apeldoorn, Aart van, Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/24901
Resumo: "Published online: 26 July 2012"
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spelling Wettability influences cell behavior on superhydrophobic surfaces with different topographiesAttachmentBlood compatibilityBoneFibronectinInterfaceMicrotopographiesMorphologyOsteoblast adhesionPoly(l-lactic acid)Protein adsorptionScience & Technology"Published online: 26 July 2012"Surface wettability and topography are recognized as critical factors influencing cell behavior on biomaterials. So far only few works have reported cell responses on surfaces exhibiting extreme wettability in combination with surface topography. The goal of this work is to study whether cell behavior on superhydrophobic surfaces is influenced by surface topography and polymer type. Biomimetic superhydrophobic rough surfaces of polystyrene and poly(l-lactic acid) with different micro/nanotopographies were obtained from smooth surfaces using a simple phase-separation based method. Total protein was quantified and showed a less adsorption of bovine serum albumin onto rough surfaces as compared to smooth surfaces of the same material. The mouse osteoblastic MC3T3-E1 cell line and primary bovine articular chondrocytes were used to study cell attachment and proliferation. Cells attached and proliferate better in the smooth surfaces. The superhydrophobic surfaces allowed cells to adhere but inhibited their proliferation. This study indicates that surface wettability, rather than polymer type or the topography of the superhydrophobic surfaces, is a critical factor in determining cell behavior.SpringerUniversidade do MinhoLourenço, Bianca do NascimentoMarchioli, GiuliaWelong SongReis, R. L.Blitterswijk, C. A. vanKarperien, MarcelApeldoorn, Aart vanMano, J. F.20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24901eng1934-863010.1007/s13758-012-0046-622833364http://dx.doi.org/10.1007/s13758-012-0046-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:52:55Zoai:repositorium.sdum.uminho.pt:1822/24901Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:52:10.221703Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Wettability influences cell behavior on superhydrophobic surfaces with different topographies
title Wettability influences cell behavior on superhydrophobic surfaces with different topographies
spellingShingle Wettability influences cell behavior on superhydrophobic surfaces with different topographies
Lourenço, Bianca do Nascimento
Attachment
Blood compatibility
Bone
Fibronectin
Interface
Microtopographies
Morphology
Osteoblast adhesion
Poly(l-lactic acid)
Protein adsorption
Science & Technology
title_short Wettability influences cell behavior on superhydrophobic surfaces with different topographies
title_full Wettability influences cell behavior on superhydrophobic surfaces with different topographies
title_fullStr Wettability influences cell behavior on superhydrophobic surfaces with different topographies
title_full_unstemmed Wettability influences cell behavior on superhydrophobic surfaces with different topographies
title_sort Wettability influences cell behavior on superhydrophobic surfaces with different topographies
author Lourenço, Bianca do Nascimento
author_facet Lourenço, Bianca do Nascimento
Marchioli, Giulia
Welong Song
Reis, R. L.
Blitterswijk, C. A. van
Karperien, Marcel
Apeldoorn, Aart van
Mano, J. F.
author_role author
author2 Marchioli, Giulia
Welong Song
Reis, R. L.
Blitterswijk, C. A. van
Karperien, Marcel
Apeldoorn, Aart van
Mano, J. F.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Lourenço, Bianca do Nascimento
Marchioli, Giulia
Welong Song
Reis, R. L.
Blitterswijk, C. A. van
Karperien, Marcel
Apeldoorn, Aart van
Mano, J. F.
dc.subject.por.fl_str_mv Attachment
Blood compatibility
Bone
Fibronectin
Interface
Microtopographies
Morphology
Osteoblast adhesion
Poly(l-lactic acid)
Protein adsorption
Science & Technology
topic Attachment
Blood compatibility
Bone
Fibronectin
Interface
Microtopographies
Morphology
Osteoblast adhesion
Poly(l-lactic acid)
Protein adsorption
Science & Technology
description "Published online: 26 July 2012"
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/24901
url http://hdl.handle.net/1822/24901
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1934-8630
10.1007/s13758-012-0046-6
22833364
http://dx.doi.org/10.1007/s13758-012-0046-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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