Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/142044 |
Resumo: | Purpose: Inflammatory cells are important promoters of tumour growth considered as prognostic factors. Glioblastoma (GBM) is no different. Hence, we intended to evaluate the inflammatory parameters, NLR, PLR, RDW-CV and RDW-SD in different phases of GBM treatment protocols, in order to understand whether there will be values that allow us to predict patient's prognosis in terms of progression free survival (PFS) and overall survival (OS). Methods: The population of this study consists of a cohort of 124 patients followed in the Neurosurgery Department of a tertiary care hospital, between January/2014 and December/2018. We performed univariate and multivariate analysis correlating NLR, PLR, RDW-CV, RDW-SV with OS and PFS per treatment time-point. Results: In our univariate analysis, several hematological parameters were related with OS and PFS. For those same parameters, we observed that pre-chemotherapy NLR value <4 had a better OS compared to values >4 (p = 0.0007) and NLR PreS-PosS (difference between pre-surgery and pos-surgery) differ significantly between patients with values < 5 and those with values > 5 (p = 0.0261). Additionally, pre-chemotherapy PLR values >9 and NLR values >4 were associated with a lower PFS (p = 0.0008; p = 0.0003). However, in multivariate analysis we did not show statistically significant values for these same parameters. Conclusions: The results of the present study demonstrated that higher pre-chemotherapy NLR and PLR values were associated with worse prognosis and NLR PreS-PosS values are associated with better prognosis. However, none of these parameters coulb be considered independent prognostic factors for GBM. |
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Avaliação sequencial de valores hematológicos como factor prognostico para doentes com GlioblastomaCiências médicas e da saúdeMedical and Health sciencesPurpose: Inflammatory cells are important promoters of tumour growth considered as prognostic factors. Glioblastoma (GBM) is no different. Hence, we intended to evaluate the inflammatory parameters, NLR, PLR, RDW-CV and RDW-SD in different phases of GBM treatment protocols, in order to understand whether there will be values that allow us to predict patient's prognosis in terms of progression free survival (PFS) and overall survival (OS). Methods: The population of this study consists of a cohort of 124 patients followed in the Neurosurgery Department of a tertiary care hospital, between January/2014 and December/2018. We performed univariate and multivariate analysis correlating NLR, PLR, RDW-CV, RDW-SV with OS and PFS per treatment time-point. Results: In our univariate analysis, several hematological parameters were related with OS and PFS. For those same parameters, we observed that pre-chemotherapy NLR value <4 had a better OS compared to values >4 (p = 0.0007) and NLR PreS-PosS (difference between pre-surgery and pos-surgery) differ significantly between patients with values < 5 and those with values > 5 (p = 0.0261). Additionally, pre-chemotherapy PLR values >9 and NLR values >4 were associated with a lower PFS (p = 0.0008; p = 0.0003). However, in multivariate analysis we did not show statistically significant values for these same parameters. Conclusions: The results of the present study demonstrated that higher pre-chemotherapy NLR and PLR values were associated with worse prognosis and NLR PreS-PosS values are associated with better prognosis. However, none of these parameters coulb be considered independent prognostic factors for GBM.2022-05-132022-05-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/142044TID:203178785porNuno Alexandre Mendes Piedadeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:31:24Zoai:repositorio-aberto.up.pt:10216/142044Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:21:55.461562Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
title |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
spellingShingle |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma Nuno Alexandre Mendes Piedade Ciências médicas e da saúde Medical and Health sciences |
title_short |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
title_full |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
title_fullStr |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
title_full_unstemmed |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
title_sort |
Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma |
author |
Nuno Alexandre Mendes Piedade |
author_facet |
Nuno Alexandre Mendes Piedade |
author_role |
author |
dc.contributor.author.fl_str_mv |
Nuno Alexandre Mendes Piedade |
dc.subject.por.fl_str_mv |
Ciências médicas e da saúde Medical and Health sciences |
topic |
Ciências médicas e da saúde Medical and Health sciences |
description |
Purpose: Inflammatory cells are important promoters of tumour growth considered as prognostic factors. Glioblastoma (GBM) is no different. Hence, we intended to evaluate the inflammatory parameters, NLR, PLR, RDW-CV and RDW-SD in different phases of GBM treatment protocols, in order to understand whether there will be values that allow us to predict patient's prognosis in terms of progression free survival (PFS) and overall survival (OS). Methods: The population of this study consists of a cohort of 124 patients followed in the Neurosurgery Department of a tertiary care hospital, between January/2014 and December/2018. We performed univariate and multivariate analysis correlating NLR, PLR, RDW-CV, RDW-SV with OS and PFS per treatment time-point. Results: In our univariate analysis, several hematological parameters were related with OS and PFS. For those same parameters, we observed that pre-chemotherapy NLR value <4 had a better OS compared to values >4 (p = 0.0007) and NLR PreS-PosS (difference between pre-surgery and pos-surgery) differ significantly between patients with values < 5 and those with values > 5 (p = 0.0261). Additionally, pre-chemotherapy PLR values >9 and NLR values >4 were associated with a lower PFS (p = 0.0008; p = 0.0003). However, in multivariate analysis we did not show statistically significant values for these same parameters. Conclusions: The results of the present study demonstrated that higher pre-chemotherapy NLR and PLR values were associated with worse prognosis and NLR PreS-PosS values are associated with better prognosis. However, none of these parameters coulb be considered independent prognostic factors for GBM. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-13 2022-05-13T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/142044 TID:203178785 |
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https://hdl.handle.net/10216/142044 |
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TID:203178785 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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