Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma

Detalhes bibliográficos
Autor(a) principal: Nuno Alexandre Mendes Piedade
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/142044
Resumo: Purpose: Inflammatory cells are important promoters of tumour growth considered as prognostic factors. Glioblastoma (GBM) is no different. Hence, we intended to evaluate the inflammatory parameters, NLR, PLR, RDW-CV and RDW-SD in different phases of GBM treatment protocols, in order to understand whether there will be values that allow us to predict patient's prognosis in terms of progression free survival (PFS) and overall survival (OS). Methods: The population of this study consists of a cohort of 124 patients followed in the Neurosurgery Department of a tertiary care hospital, between January/2014 and December/2018. We performed univariate and multivariate analysis correlating NLR, PLR, RDW-CV, RDW-SV with OS and PFS per treatment time-point. Results: In our univariate analysis, several hematological parameters were related with OS and PFS. For those same parameters, we observed that pre-chemotherapy NLR value <4 had a better OS compared to values >4 (p = 0.0007) and NLR PreS-PosS (difference between pre-surgery and pos-surgery) differ significantly between patients with values < 5 and those with values > 5 (p = 0.0261). Additionally, pre-chemotherapy PLR values >9 and NLR values >4 were associated with a lower PFS (p = 0.0008; p = 0.0003). However, in multivariate analysis we did not show statistically significant values for these same parameters. Conclusions: The results of the present study demonstrated that higher pre-chemotherapy NLR and PLR values were associated with worse prognosis and NLR PreS-PosS values are associated with better prognosis. However, none of these parameters coulb be considered independent prognostic factors for GBM.
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spelling Avaliação sequencial de valores hematológicos como factor prognostico para doentes com GlioblastomaCiências médicas e da saúdeMedical and Health sciencesPurpose: Inflammatory cells are important promoters of tumour growth considered as prognostic factors. Glioblastoma (GBM) is no different. Hence, we intended to evaluate the inflammatory parameters, NLR, PLR, RDW-CV and RDW-SD in different phases of GBM treatment protocols, in order to understand whether there will be values that allow us to predict patient's prognosis in terms of progression free survival (PFS) and overall survival (OS). Methods: The population of this study consists of a cohort of 124 patients followed in the Neurosurgery Department of a tertiary care hospital, between January/2014 and December/2018. We performed univariate and multivariate analysis correlating NLR, PLR, RDW-CV, RDW-SV with OS and PFS per treatment time-point. Results: In our univariate analysis, several hematological parameters were related with OS and PFS. For those same parameters, we observed that pre-chemotherapy NLR value <4 had a better OS compared to values >4 (p = 0.0007) and NLR PreS-PosS (difference between pre-surgery and pos-surgery) differ significantly between patients with values < 5 and those with values > 5 (p = 0.0261). Additionally, pre-chemotherapy PLR values >9 and NLR values >4 were associated with a lower PFS (p = 0.0008; p = 0.0003). However, in multivariate analysis we did not show statistically significant values for these same parameters. Conclusions: The results of the present study demonstrated that higher pre-chemotherapy NLR and PLR values were associated with worse prognosis and NLR PreS-PosS values are associated with better prognosis. However, none of these parameters coulb be considered independent prognostic factors for GBM.2022-05-132022-05-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/142044TID:203178785porNuno Alexandre Mendes Piedadeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:31:24Zoai:repositorio-aberto.up.pt:10216/142044Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:21:55.461562Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
title Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
spellingShingle Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
Nuno Alexandre Mendes Piedade
Ciências médicas e da saúde
Medical and Health sciences
title_short Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
title_full Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
title_fullStr Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
title_full_unstemmed Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
title_sort Avaliação sequencial de valores hematológicos como factor prognostico para doentes com Glioblastoma
author Nuno Alexandre Mendes Piedade
author_facet Nuno Alexandre Mendes Piedade
author_role author
dc.contributor.author.fl_str_mv Nuno Alexandre Mendes Piedade
dc.subject.por.fl_str_mv Ciências médicas e da saúde
Medical and Health sciences
topic Ciências médicas e da saúde
Medical and Health sciences
description Purpose: Inflammatory cells are important promoters of tumour growth considered as prognostic factors. Glioblastoma (GBM) is no different. Hence, we intended to evaluate the inflammatory parameters, NLR, PLR, RDW-CV and RDW-SD in different phases of GBM treatment protocols, in order to understand whether there will be values that allow us to predict patient's prognosis in terms of progression free survival (PFS) and overall survival (OS). Methods: The population of this study consists of a cohort of 124 patients followed in the Neurosurgery Department of a tertiary care hospital, between January/2014 and December/2018. We performed univariate and multivariate analysis correlating NLR, PLR, RDW-CV, RDW-SV with OS and PFS per treatment time-point. Results: In our univariate analysis, several hematological parameters were related with OS and PFS. For those same parameters, we observed that pre-chemotherapy NLR value <4 had a better OS compared to values >4 (p = 0.0007) and NLR PreS-PosS (difference between pre-surgery and pos-surgery) differ significantly between patients with values < 5 and those with values > 5 (p = 0.0261). Additionally, pre-chemotherapy PLR values >9 and NLR values >4 were associated with a lower PFS (p = 0.0008; p = 0.0003). However, in multivariate analysis we did not show statistically significant values for these same parameters. Conclusions: The results of the present study demonstrated that higher pre-chemotherapy NLR and PLR values were associated with worse prognosis and NLR PreS-PosS values are associated with better prognosis. However, none of these parameters coulb be considered independent prognostic factors for GBM.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-13
2022-05-13T00:00:00Z
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TID:203178785
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