Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy

Detalhes bibliográficos
Autor(a) principal: Sousa, Ana Rita Lima
Data de Publicação: 2018
Outros Autores: Diogo, Duarte Miguel de Melo, Alves, Cátia, Costa, Elisabete C., Ferreira, Paula, Louro, Ricardo, Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/5684
Resumo: Reduced graphene oxide (rGO) nanomaterials display promising properties for application in cancer photothermal therapy (PTT). rGO is usually obtained by treating graphene oxide (GO) with hydrazine hydrate. However, this reducing agent contributes for the low cytocompatibility exhibited by rGO. Furthermore, rGO has a low water stability and does not show selectivity towards cancer cells. Herein, rGO attained using an environmentally-friendly method was functionalized with a novel hyaluronic acid (HA)-based amphiphilic polymer to be used in targeted cancer PTT. Initially, the green-reduction of GO with L-Ascorbic acid was optimized considering the near infrared absorption and the size distribution of the nanomaterials. Then, rGO was functionalized with the HA-based amphiphile. The functionalization of rGO improved its stability, cytocompatibility and internalization by CD44 overexpressing cells, which indicates the targeting capacity of this nanoformulation. Furthermore, the on-demand PTT mediated by HA-functionalized rGO induced cancer cells’ ablation, thereby confirming its potential for targeted cancer therapy.
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spelling Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy2D materialsTargeted therapyPhotothermal effectHyaluronanGreen chemistryReduced graphene oxide (rGO) nanomaterials display promising properties for application in cancer photothermal therapy (PTT). rGO is usually obtained by treating graphene oxide (GO) with hydrazine hydrate. However, this reducing agent contributes for the low cytocompatibility exhibited by rGO. Furthermore, rGO has a low water stability and does not show selectivity towards cancer cells. Herein, rGO attained using an environmentally-friendly method was functionalized with a novel hyaluronic acid (HA)-based amphiphilic polymer to be used in targeted cancer PTT. Initially, the green-reduction of GO with L-Ascorbic acid was optimized considering the near infrared absorption and the size distribution of the nanomaterials. Then, rGO was functionalized with the HA-based amphiphile. The functionalization of rGO improved its stability, cytocompatibility and internalization by CD44 overexpressing cells, which indicates the targeting capacity of this nanoformulation. Furthermore, the on-demand PTT mediated by HA-functionalized rGO induced cancer cells’ ablation, thereby confirming its potential for targeted cancer therapy.ElsevieruBibliorumSousa, Ana Rita LimaDiogo, Duarte Miguel de MeloAlves, CátiaCosta, Elisabete C.Ferreira, PaulaLouro, RicardoCorreia, Ilídio Joaquim Sobreira2018-08-23T09:05:15Z2018-07-242018-07-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/5684engSousa, R. L., de Melo-Diogo, D., Alves, C. G., Costa, E. C., Ferreira, P., Louro, R. O., Correia, I.J. (2018) "Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy", Carbohydrate Polymers, Vol. 200, pp. 93-99.10.1016/j.carbpol.2018.07.066metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-20T02:30:34Zoai:ubibliorum.ubi.pt:10400.6/5684Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:46:33.884444Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
title Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
spellingShingle Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
Sousa, Ana Rita Lima
2D materials
Targeted therapy
Photothermal effect
Hyaluronan
Green chemistry
title_short Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
title_full Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
title_fullStr Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
title_full_unstemmed Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
title_sort Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy
author Sousa, Ana Rita Lima
author_facet Sousa, Ana Rita Lima
Diogo, Duarte Miguel de Melo
Alves, Cátia
Costa, Elisabete C.
Ferreira, Paula
Louro, Ricardo
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Diogo, Duarte Miguel de Melo
Alves, Cátia
Costa, Elisabete C.
Ferreira, Paula
Louro, Ricardo
Correia, Ilídio Joaquim Sobreira
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Sousa, Ana Rita Lima
Diogo, Duarte Miguel de Melo
Alves, Cátia
Costa, Elisabete C.
Ferreira, Paula
Louro, Ricardo
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv 2D materials
Targeted therapy
Photothermal effect
Hyaluronan
Green chemistry
topic 2D materials
Targeted therapy
Photothermal effect
Hyaluronan
Green chemistry
description Reduced graphene oxide (rGO) nanomaterials display promising properties for application in cancer photothermal therapy (PTT). rGO is usually obtained by treating graphene oxide (GO) with hydrazine hydrate. However, this reducing agent contributes for the low cytocompatibility exhibited by rGO. Furthermore, rGO has a low water stability and does not show selectivity towards cancer cells. Herein, rGO attained using an environmentally-friendly method was functionalized with a novel hyaluronic acid (HA)-based amphiphilic polymer to be used in targeted cancer PTT. Initially, the green-reduction of GO with L-Ascorbic acid was optimized considering the near infrared absorption and the size distribution of the nanomaterials. Then, rGO was functionalized with the HA-based amphiphile. The functionalization of rGO improved its stability, cytocompatibility and internalization by CD44 overexpressing cells, which indicates the targeting capacity of this nanoformulation. Furthermore, the on-demand PTT mediated by HA-functionalized rGO induced cancer cells’ ablation, thereby confirming its potential for targeted cancer therapy.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-23T09:05:15Z
2018-07-24
2018-07-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/5684
url http://hdl.handle.net/10400.6/5684
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sousa, R. L., de Melo-Diogo, D., Alves, C. G., Costa, E. C., Ferreira, P., Louro, R. O., Correia, I.J. (2018) "Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy", Carbohydrate Polymers, Vol. 200, pp. 93-99.
10.1016/j.carbpol.2018.07.066
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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