Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/46408 |
Resumo: | © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.Springer NatureRepositório da Universidade de LisboaGuerreiro Stucklin, Ana S.Ryall, ScottFukuoka, KoheiZapotocky, MichalLassaletta, AlvaroLi, ChristopherBridge, TaylorKim, ByungjinArnoldo, AnthonyKowalski, Paul E.Zhong, YvonneJohnson, MoniqueLi, ClaireRamani, Arun K.Siddaway, RobertNobre, Liana Figueiredode Antonellis, PasqualinoDunham, ChristopherCheng, SylviaBoué, Daniel R.Finlay, Jonathan L.Coven, Scott L.de Prada, InmaculadaPerez-Somarriba, MartaFaria, ClaudiaGrotzer, Michael A.Rushing, ElisabethSumerauer, DavidZamecnik, JosefKrskova, LenkaGarcia Ariza, MiguelCruz, OfeliaMorales La Madrid, AndresSolano, PalmaTerashima, KeitaNakano, YoshikoIchimura, KoichiNagane, MotooSakamoto, HiroakiGil-da-Costa, Maria JoaoSilva, RobertoJohnston, Donna L.Michaud, JeanWilson, Bevvan Landeghem, Frank K. H.Oviedo, AngelicaMcNeely, P. DanielCrooks, BruceFried, IrisZhukova, NataliyaHansford, Jordan R.Nageswararao, AmulyaGarzia, LiviaShago, MaryBrudno, MichaelIrwin, Meredith S.Bartels, UteRamaswamy, VijayBouffet, EricTaylor, Michael D.Tabori, UriHawkins, Cynthia2021-02-17T17:16:53Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46408engNat Commun. 2019 Sep 25;10(1):434310.1038/s41467-019-12187-52041-1723info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:42Zoai:repositorio.ul.pt:10451/46408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:35.745894Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
title |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
spellingShingle |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas Guerreiro Stucklin, Ana S. |
title_short |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
title_full |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
title_fullStr |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
title_full_unstemmed |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
title_sort |
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas |
author |
Guerreiro Stucklin, Ana S. |
author_facet |
Guerreiro Stucklin, Ana S. Ryall, Scott Fukuoka, Kohei Zapotocky, Michal Lassaletta, Alvaro Li, Christopher Bridge, Taylor Kim, Byungjin Arnoldo, Anthony Kowalski, Paul E. Zhong, Yvonne Johnson, Monique Li, Claire Ramani, Arun K. Siddaway, Robert Nobre, Liana Figueiredo de Antonellis, Pasqualino Dunham, Christopher Cheng, Sylvia Boué, Daniel R. Finlay, Jonathan L. Coven, Scott L. de Prada, Inmaculada Perez-Somarriba, Marta Faria, Claudia Grotzer, Michael A. Rushing, Elisabeth Sumerauer, David Zamecnik, Josef Krskova, Lenka Garcia Ariza, Miguel Cruz, Ofelia Morales La Madrid, Andres Solano, Palma Terashima, Keita Nakano, Yoshiko Ichimura, Koichi Nagane, Motoo Sakamoto, Hiroaki Gil-da-Costa, Maria Joao Silva, Roberto Johnston, Donna L. Michaud, Jean Wilson, Bev van Landeghem, Frank K. H. Oviedo, Angelica McNeely, P. Daniel Crooks, Bruce Fried, Iris Zhukova, Nataliya Hansford, Jordan R. Nageswararao, Amulya Garzia, Livia Shago, Mary Brudno, Michael Irwin, Meredith S. Bartels, Ute Ramaswamy, Vijay Bouffet, Eric Taylor, Michael D. Tabori, Uri Hawkins, Cynthia |
author_role |
author |
author2 |
Ryall, Scott Fukuoka, Kohei Zapotocky, Michal Lassaletta, Alvaro Li, Christopher Bridge, Taylor Kim, Byungjin Arnoldo, Anthony Kowalski, Paul E. Zhong, Yvonne Johnson, Monique Li, Claire Ramani, Arun K. Siddaway, Robert Nobre, Liana Figueiredo de Antonellis, Pasqualino Dunham, Christopher Cheng, Sylvia Boué, Daniel R. Finlay, Jonathan L. Coven, Scott L. de Prada, Inmaculada Perez-Somarriba, Marta Faria, Claudia Grotzer, Michael A. Rushing, Elisabeth Sumerauer, David Zamecnik, Josef Krskova, Lenka Garcia Ariza, Miguel Cruz, Ofelia Morales La Madrid, Andres Solano, Palma Terashima, Keita Nakano, Yoshiko Ichimura, Koichi Nagane, Motoo Sakamoto, Hiroaki Gil-da-Costa, Maria Joao Silva, Roberto Johnston, Donna L. Michaud, Jean Wilson, Bev van Landeghem, Frank K. H. Oviedo, Angelica McNeely, P. Daniel Crooks, Bruce Fried, Iris Zhukova, Nataliya Hansford, Jordan R. Nageswararao, Amulya Garzia, Livia Shago, Mary Brudno, Michael Irwin, Meredith S. Bartels, Ute Ramaswamy, Vijay Bouffet, Eric Taylor, Michael D. Tabori, Uri Hawkins, Cynthia |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Guerreiro Stucklin, Ana S. Ryall, Scott Fukuoka, Kohei Zapotocky, Michal Lassaletta, Alvaro Li, Christopher Bridge, Taylor Kim, Byungjin Arnoldo, Anthony Kowalski, Paul E. Zhong, Yvonne Johnson, Monique Li, Claire Ramani, Arun K. Siddaway, Robert Nobre, Liana Figueiredo de Antonellis, Pasqualino Dunham, Christopher Cheng, Sylvia Boué, Daniel R. Finlay, Jonathan L. Coven, Scott L. de Prada, Inmaculada Perez-Somarriba, Marta Faria, Claudia Grotzer, Michael A. Rushing, Elisabeth Sumerauer, David Zamecnik, Josef Krskova, Lenka Garcia Ariza, Miguel Cruz, Ofelia Morales La Madrid, Andres Solano, Palma Terashima, Keita Nakano, Yoshiko Ichimura, Koichi Nagane, Motoo Sakamoto, Hiroaki Gil-da-Costa, Maria Joao Silva, Roberto Johnston, Donna L. Michaud, Jean Wilson, Bev van Landeghem, Frank K. H. Oviedo, Angelica McNeely, P. Daniel Crooks, Bruce Fried, Iris Zhukova, Nataliya Hansford, Jordan R. Nageswararao, Amulya Garzia, Livia Shago, Mary Brudno, Michael Irwin, Meredith S. Bartels, Ute Ramaswamy, Vijay Bouffet, Eric Taylor, Michael D. Tabori, Uri Hawkins, Cynthia |
description |
© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2021-02-17T17:16:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/46408 |
url |
http://hdl.handle.net/10451/46408 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nat Commun. 2019 Sep 25;10(1):4343 10.1038/s41467-019-12187-5 2041-1723 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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