Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.23/671 |
Resumo: | Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD. |
id |
RCAP_a2f4c8f36a875e8b18dcc9ae08e1b6c2 |
---|---|
oai_identifier_str |
oai:repositorio.hospitaldebraga.pt:10400.23/671 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney diseaseDiabetes Mellitus Tipo 2HipoglicemiantesInsuficiência Renal CrónicaChronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD.Repositório Científico do Hospital de BragaNogueira, CSouto, SBVinha, ECarvalho-Braga, DCarvalho, D2014-07-28T20:47:29Z2013-01-01T00:00:00Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/671engHormones. 2013 Oct-Dec;12(4):483-94info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:23Zoai:repositorio.hospitaldebraga.pt:10400.23/671Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:20.256907Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
title |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
spellingShingle |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease Nogueira, C Diabetes Mellitus Tipo 2 Hipoglicemiantes Insuficiência Renal Crónica |
title_short |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
title_full |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
title_fullStr |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
title_full_unstemmed |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
title_sort |
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease |
author |
Nogueira, C |
author_facet |
Nogueira, C Souto, SB Vinha, E Carvalho-Braga, D Carvalho, D |
author_role |
author |
author2 |
Souto, SB Vinha, E Carvalho-Braga, D Carvalho, D |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Hospital de Braga |
dc.contributor.author.fl_str_mv |
Nogueira, C Souto, SB Vinha, E Carvalho-Braga, D Carvalho, D |
dc.subject.por.fl_str_mv |
Diabetes Mellitus Tipo 2 Hipoglicemiantes Insuficiência Renal Crónica |
topic |
Diabetes Mellitus Tipo 2 Hipoglicemiantes Insuficiência Renal Crónica |
description |
Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01T00:00:00Z 2013-01-01T00:00:00Z 2014-07-28T20:47:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.23/671 |
url |
http://hdl.handle.net/10400.23/671 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hormones. 2013 Oct-Dec;12(4):483-94 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130420761067520 |