Highly water soluble room temperature superionic liquids of APIs
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/99957 |
Resumo: | Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses. |
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7160 |
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Highly water soluble room temperature superionic liquids of APIsPROTIC IONIC LIQUIDSACTIVE PHARMACEUTICAL INGREDIENTSAMPICILLINFORMSCIPROFLOXACINACIDNORFLOXACINSTABILITYLIPOSOMESCatalysisChemistry(all)Materials ChemistryFundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.LAQV@REQUIMTEDQ - Departamento de QuímicaInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNCarrera, Gonçalo V. S. M.Santos, Miguel M.Costa, AlexandraRebelo, Luis Paulo N.Marrucho, Isabel M.Nunes da Ponte, M.Branco, Luis C.2020-06-25T22:52:42Z2017-08-072017-08-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://hdl.handle.net/10362/99957eng1144-0546PURE: 3838175https://doi.org/10.1039/c7nj01398ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:46:39Zoai:run.unl.pt:10362/99957Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:39:17.600490Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Highly water soluble room temperature superionic liquids of APIs |
title |
Highly water soluble room temperature superionic liquids of APIs |
spellingShingle |
Highly water soluble room temperature superionic liquids of APIs Carrera, Gonçalo V. S. M. PROTIC IONIC LIQUIDS ACTIVE PHARMACEUTICAL INGREDIENTS AMPICILLIN FORMS CIPROFLOXACIN ACID NORFLOXACIN STABILITY LIPOSOMES Catalysis Chemistry(all) Materials Chemistry |
title_short |
Highly water soluble room temperature superionic liquids of APIs |
title_full |
Highly water soluble room temperature superionic liquids of APIs |
title_fullStr |
Highly water soluble room temperature superionic liquids of APIs |
title_full_unstemmed |
Highly water soluble room temperature superionic liquids of APIs |
title_sort |
Highly water soluble room temperature superionic liquids of APIs |
author |
Carrera, Gonçalo V. S. M. |
author_facet |
Carrera, Gonçalo V. S. M. Santos, Miguel M. Costa, Alexandra Rebelo, Luis Paulo N. Marrucho, Isabel M. Nunes da Ponte, M. Branco, Luis C. |
author_role |
author |
author2 |
Santos, Miguel M. Costa, Alexandra Rebelo, Luis Paulo N. Marrucho, Isabel M. Nunes da Ponte, M. Branco, Luis C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
dc.contributor.author.fl_str_mv |
Carrera, Gonçalo V. S. M. Santos, Miguel M. Costa, Alexandra Rebelo, Luis Paulo N. Marrucho, Isabel M. Nunes da Ponte, M. Branco, Luis C. |
dc.subject.por.fl_str_mv |
PROTIC IONIC LIQUIDS ACTIVE PHARMACEUTICAL INGREDIENTS AMPICILLIN FORMS CIPROFLOXACIN ACID NORFLOXACIN STABILITY LIPOSOMES Catalysis Chemistry(all) Materials Chemistry |
topic |
PROTIC IONIC LIQUIDS ACTIVE PHARMACEUTICAL INGREDIENTS AMPICILLIN FORMS CIPROFLOXACIN ACID NORFLOXACIN STABILITY LIPOSOMES Catalysis Chemistry(all) Materials Chemistry |
description |
Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-07 2017-08-07T00:00:00Z 2020-06-25T22:52:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/99957 |
url |
http://hdl.handle.net/10362/99957 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1144-0546 PURE: 3838175 https://doi.org/10.1039/c7nj01398a |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138009126273024 |