Microparticles in contact with cells: from carriers to multifunctional tissue modulators

Detalhes bibliográficos
Autor(a) principal: Neto, Mafalda D.
Data de Publicação: 2019
Outros Autores: Oliveira, Mariana B., Mano, João F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/34397
Resumo: For several decades microparticles have been exclusively and extensively explored as spherical drug delivery vehicles and large-scale cell expansion carriers. More recently, microparticulate structures gained interest in broader bioengineering fields, integrating myriad strategies that include bottom-up tissue engineering, 3D bioprinting, and the development of tissue/disease models. The concept of bulk spherical micrometric particles as adequate supports for cell cultivation has been challenged, and systems with finely tuned geometric designs and (bio)chemical/physical features are current key players in impacting technologies. Herein, we critically review the state of the art and future trends of biomaterial microparticles in contact with cells and tissues, excluding internalization studies, and with emphasis on innovative particle design and applications.
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spelling Microparticles in contact with cells: from carriers to multifunctional tissue modulatorsAdvanced microcarriersBioinksBottom-up tissue engineeringBuilding blocksIn vitro 3D modelsMicroparticle designFor several decades microparticles have been exclusively and extensively explored as spherical drug delivery vehicles and large-scale cell expansion carriers. More recently, microparticulate structures gained interest in broader bioengineering fields, integrating myriad strategies that include bottom-up tissue engineering, 3D bioprinting, and the development of tissue/disease models. The concept of bulk spherical micrometric particles as adequate supports for cell cultivation has been challenged, and systems with finely tuned geometric designs and (bio)chemical/physical features are current key players in impacting technologies. Herein, we critically review the state of the art and future trends of biomaterial microparticles in contact with cells and tissues, excluding internalization studies, and with emphasis on innovative particle design and applications.Cell Press2022-08-03T16:11:45Z2019-09-01T00:00:00Z2019-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34397eng0167-779910.1016/j.tibtech.2019.02.008Neto, Mafalda D.Oliveira, Mariana B.Mano, João F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:28Zoai:ria.ua.pt:10773/34397Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:44.951236Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Microparticles in contact with cells: from carriers to multifunctional tissue modulators
title Microparticles in contact with cells: from carriers to multifunctional tissue modulators
spellingShingle Microparticles in contact with cells: from carriers to multifunctional tissue modulators
Neto, Mafalda D.
Advanced microcarriers
Bioinks
Bottom-up tissue engineering
Building blocks
In vitro 3D models
Microparticle design
title_short Microparticles in contact with cells: from carriers to multifunctional tissue modulators
title_full Microparticles in contact with cells: from carriers to multifunctional tissue modulators
title_fullStr Microparticles in contact with cells: from carriers to multifunctional tissue modulators
title_full_unstemmed Microparticles in contact with cells: from carriers to multifunctional tissue modulators
title_sort Microparticles in contact with cells: from carriers to multifunctional tissue modulators
author Neto, Mafalda D.
author_facet Neto, Mafalda D.
Oliveira, Mariana B.
Mano, João F.
author_role author
author2 Oliveira, Mariana B.
Mano, João F.
author2_role author
author
dc.contributor.author.fl_str_mv Neto, Mafalda D.
Oliveira, Mariana B.
Mano, João F.
dc.subject.por.fl_str_mv Advanced microcarriers
Bioinks
Bottom-up tissue engineering
Building blocks
In vitro 3D models
Microparticle design
topic Advanced microcarriers
Bioinks
Bottom-up tissue engineering
Building blocks
In vitro 3D models
Microparticle design
description For several decades microparticles have been exclusively and extensively explored as spherical drug delivery vehicles and large-scale cell expansion carriers. More recently, microparticulate structures gained interest in broader bioengineering fields, integrating myriad strategies that include bottom-up tissue engineering, 3D bioprinting, and the development of tissue/disease models. The concept of bulk spherical micrometric particles as adequate supports for cell cultivation has been challenged, and systems with finely tuned geometric designs and (bio)chemical/physical features are current key players in impacting technologies. Herein, we critically review the state of the art and future trends of biomaterial microparticles in contact with cells and tissues, excluding internalization studies, and with emphasis on innovative particle design and applications.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01T00:00:00Z
2019-09
2022-08-03T16:11:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/34397
url http://hdl.handle.net/10773/34397
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0167-7799
10.1016/j.tibtech.2019.02.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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