It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ana Luísa
Data de Publicação: 2021
Outros Autores: Fernandes, Dominique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/105358
https://doi.org/10.1371/journal.pbio.3001448
Resumo: Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.
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spelling It takes two to tango: Concerted protein translation and degradation necessary for synaptic scalingNeuronsMicroRNAsProtein BiosynthesisSynaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.Public Library of Science2021-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105358http://hdl.handle.net/10316/105358https://doi.org/10.1371/journal.pbio.3001448eng1545-7885Carvalho, Ana LuísaFernandes, Dominiqueinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-02-20T10:46:48Zoai:estudogeral.uc.pt:10316/105358Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:56.943757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
spellingShingle It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
Carvalho, Ana Luísa
Neurons
MicroRNAs
Protein Biosynthesis
title_short It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_full It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_fullStr It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_full_unstemmed It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_sort It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
author Carvalho, Ana Luísa
author_facet Carvalho, Ana Luísa
Fernandes, Dominique
author_role author
author2 Fernandes, Dominique
author2_role author
dc.contributor.author.fl_str_mv Carvalho, Ana Luísa
Fernandes, Dominique
dc.subject.por.fl_str_mv Neurons
MicroRNAs
Protein Biosynthesis
topic Neurons
MicroRNAs
Protein Biosynthesis
description Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/105358
http://hdl.handle.net/10316/105358
https://doi.org/10.1371/journal.pbio.3001448
url http://hdl.handle.net/10316/105358
https://doi.org/10.1371/journal.pbio.3001448
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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