Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease

Detalhes bibliográficos
Autor(a) principal: Lacerda, Joana Franco
Data de Publicação: 2021
Outros Autores: Lagos, Ana Catarina, Carolino, Elisabete, Silva-Herdade, Ana S., Silva, Manuel, Guerreiro, Catarina Sousa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46999
Resumo: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
id RCAP_a3d7d92e4f705dae2d887dce07868a0d
oai_identifier_str oai:repositorio.ul.pt:10451/46999
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel diseaseInflammatory bowel diseaseIntestinal permeabilitySerum zonulinInflammationFunctional foodsCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Inflammatory bowel diseases (IBD) are characterized by a chronic inflammatory process that affects the intestinal barrier structure. Recent evidence suggests that some food components can influence the integrity of the intestinal barrier and thus its permeability. We aimed at assessing the effect of food components on the intestinal permeability (IP) and on inflammatory markers in individuals with IBD by a single-blind randomized clinical study. Of the 53 individuals included, 47% (n = 25) had been diagnosed with IBD. The participants were divided into 4 groups. IBD patients were allocated to intervention group (n = 14) vs. no intervention group (n = 11), and the same happened with 28 control participants without disease (n = 14 in intervention group vs. n = 14 without intervention). Symptomatology, nutritional status, biochemical parameters (specifically serum zonulin (ZO) to measure IP) were evaluated on all individuals on an eight week period following a diet plan with/without potentially beneficial foods for the IP. At the beginning of the study, there were no significant differences in ZO values between individuals with and without IBD (p > 0.05). The effect of specific food components was inconclusive; however, a trend in the reduction of inflammatory parameters and on the prevalence of gastrointestinal symptomatology was observed. More controlled intervention studies with diet plans, including food components potentially beneficial for the integrity of the intestinal barrier, are of the utmost importance.MDPIRepositório da Universidade de LisboaLacerda, Joana FrancoLagos, Ana CatarinaCarolino, ElisabeteSilva-Herdade, Ana S.Silva, ManuelGuerreiro, Catarina Sousa2021-03-23T16:18:48Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46999engNutrients 13, no. 2: 642.10.3390/nu130206422072-6643info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:36Zoai:repositorio.ul.pt:10451/46999Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:06.231357Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
title Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
spellingShingle Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
Lacerda, Joana Franco
Inflammatory bowel disease
Intestinal permeability
Serum zonulin
Inflammation
Functional foods
title_short Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
title_full Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
title_fullStr Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
title_full_unstemmed Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
title_sort Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
author Lacerda, Joana Franco
author_facet Lacerda, Joana Franco
Lagos, Ana Catarina
Carolino, Elisabete
Silva-Herdade, Ana S.
Silva, Manuel
Guerreiro, Catarina Sousa
author_role author
author2 Lagos, Ana Catarina
Carolino, Elisabete
Silva-Herdade, Ana S.
Silva, Manuel
Guerreiro, Catarina Sousa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Lacerda, Joana Franco
Lagos, Ana Catarina
Carolino, Elisabete
Silva-Herdade, Ana S.
Silva, Manuel
Guerreiro, Catarina Sousa
dc.subject.por.fl_str_mv Inflammatory bowel disease
Intestinal permeability
Serum zonulin
Inflammation
Functional foods
topic Inflammatory bowel disease
Intestinal permeability
Serum zonulin
Inflammation
Functional foods
description Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-03-23T16:18:48Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46999
url http://hdl.handle.net/10451/46999
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nutrients 13, no. 2: 642.
10.3390/nu13020642
2072-6643
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134536513093632

Registros relacionados