A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves

Detalhes bibliográficos
Autor(a) principal: Moujir, Laila M.
Data de Publicação: 2011
Outros Autores: Seca, Ana M. L., Araujo, Liliana, Silva, Artur M. S., Barreto, Maria do Carmo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/2939
Resumo: Copyright © 2010 Elsevier B.V. All rights reserved.
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spelling A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves3,4-DehydrotheaspironeJuniperus brevifoliaCupressaceaeDiterpenesCytotoxicityAntimicrobial ActivityCopyright © 2010 Elsevier B.V. All rights reserved.A new natural spiro compound 3,4-dehydrotheaspirone 1 and the known arctiol [1β,6α-dihydroxy-4(14)-eudesmene] 2 were isolated from Juniperus brevifolia. Arctiol is reported for the first time in the Juniperus genus. Their structures were established by 1D, and 2D NMR and MS spectra. Antimicrobial and cytotoxic activities of 1 and several secondary metabolites 3,4,5,6,7,8,9,10,11,12 previously isolated by our group from J. brevifolia were evaluated and some SAR has been established. The 18-hydroxydehydroabietane displayed great antiproliferative activity against cancer cell lines tested, namely HeLa, A-549 and MCF-7. Compound also presented a significant bactericidal effect against Bacillus cereus at different concentrations tested.ElsevierRepositório da Universidade dos AçoresMoujir, Laila M.Seca, Ana M. L.Araujo, LilianaSilva, Artur M. S.Barreto, Maria do Carmo2014-03-31T12:04:29Z2011-032014-03-27T21:22:05Z2011-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/2939engMoujir, Laila M.; Seca, Ana M.L.; Araujo, Liliana; Silva, Artur M.S.; Barreto, M. Carmo (2011). "A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves", Fitoterapia, 82(2), 225-229. DOI: 10.1016/j.fitote.2010.10.001.0367-326X (Print)metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:30:48Zoai:repositorio.uac.pt:10400.3/2939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:25:33.437172Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
title A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
spellingShingle A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
Moujir, Laila M.
3,4-Dehydrotheaspirone
Juniperus brevifolia
Cupressaceae
Diterpenes
Cytotoxicity
Antimicrobial Activity
title_short A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
title_full A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
title_fullStr A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
title_full_unstemmed A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
title_sort A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves
author Moujir, Laila M.
author_facet Moujir, Laila M.
Seca, Ana M. L.
Araujo, Liliana
Silva, Artur M. S.
Barreto, Maria do Carmo
author_role author
author2 Seca, Ana M. L.
Araujo, Liliana
Silva, Artur M. S.
Barreto, Maria do Carmo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Moujir, Laila M.
Seca, Ana M. L.
Araujo, Liliana
Silva, Artur M. S.
Barreto, Maria do Carmo
dc.subject.por.fl_str_mv 3,4-Dehydrotheaspirone
Juniperus brevifolia
Cupressaceae
Diterpenes
Cytotoxicity
Antimicrobial Activity
topic 3,4-Dehydrotheaspirone
Juniperus brevifolia
Cupressaceae
Diterpenes
Cytotoxicity
Antimicrobial Activity
description Copyright © 2010 Elsevier B.V. All rights reserved.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
2011-03-01T00:00:00Z
2014-03-31T12:04:29Z
2014-03-27T21:22:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/2939
url http://hdl.handle.net/10400.3/2939
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moujir, Laila M.; Seca, Ana M.L.; Araujo, Liliana; Silva, Artur M.S.; Barreto, M. Carmo (2011). "A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves", Fitoterapia, 82(2), 225-229. DOI: 10.1016/j.fitote.2010.10.001.
0367-326X (Print)
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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