Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress.
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/134564 |
Resumo: | Introduction and objectives: Acute heart failure (AHF) and cardiogenic shock (CS) are associated with high hospitalization and mortality rates. Renin-angiotensin-aldosterone system (RAAS) activation and redox dysfunction contribute to cardiac and renal dysfunction, but their interplay in human AHF and CS has not been explored. We aimed to investigate plasma and urinary angiotensinogen (P-AGT; U-AGT, an intrarenal RAAS marker) and urinary H2O2 (U-H2O2) in AHF and CS patients. Furthermore, we evaluated the correlations between them, as well as their association with endothelial dysfunction, inflammation, oxidative stress and cardiac and renal impairment. Methods: Patients with AHF (n=23) or CS (n=25) and healthy controls (n=22) were included. U-AGT, P-AGT, U-H2O2, endothelial dysfunction, inflammation, oxidative stress and cardiac/renal impairment markers were evaluated at days 1-2 (admission), days 3-4 and days 5-8 in AHF and CS patients and at a single time point in controls. Results: At admission, AHF and CS patients had similar P-AGT, higher U-AGT and lower U-H2O2 than controls. There were no changes in P-AGT, U-AGT or U-H2O2 along hospitalization. P-AGT and U-AGT positively correlated with endothelial dysfunction, inflammation and oxidative stress, while U-H2O2 negatively correlated with these biomarkers and with U-AGT in the overall study population. Among patients, U-H2O2 positively correlated with inflammation, oxidative stress and P-AGT, and both U-AGT and U-H2O2 were associated with renal impairment. Conclusions: AHF and CS patients appear to have intrarenal RAAS activation and increased H2O2 consumption, probably by myeloperoxidase. Furthermore, their association with renal dysfunction is likely related to endothelial injury, inflammation and oxidative stress. |
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Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress.Medicina clínicaClinical medicineIntroduction and objectives: Acute heart failure (AHF) and cardiogenic shock (CS) are associated with high hospitalization and mortality rates. Renin-angiotensin-aldosterone system (RAAS) activation and redox dysfunction contribute to cardiac and renal dysfunction, but their interplay in human AHF and CS has not been explored. We aimed to investigate plasma and urinary angiotensinogen (P-AGT; U-AGT, an intrarenal RAAS marker) and urinary H2O2 (U-H2O2) in AHF and CS patients. Furthermore, we evaluated the correlations between them, as well as their association with endothelial dysfunction, inflammation, oxidative stress and cardiac and renal impairment. Methods: Patients with AHF (n=23) or CS (n=25) and healthy controls (n=22) were included. U-AGT, P-AGT, U-H2O2, endothelial dysfunction, inflammation, oxidative stress and cardiac/renal impairment markers were evaluated at days 1-2 (admission), days 3-4 and days 5-8 in AHF and CS patients and at a single time point in controls. Results: At admission, AHF and CS patients had similar P-AGT, higher U-AGT and lower U-H2O2 than controls. There were no changes in P-AGT, U-AGT or U-H2O2 along hospitalization. P-AGT and U-AGT positively correlated with endothelial dysfunction, inflammation and oxidative stress, while U-H2O2 negatively correlated with these biomarkers and with U-AGT in the overall study population. Among patients, U-H2O2 positively correlated with inflammation, oxidative stress and P-AGT, and both U-AGT and U-H2O2 were associated with renal impairment. Conclusions: AHF and CS patients appear to have intrarenal RAAS activation and increased H2O2 consumption, probably by myeloperoxidase. Furthermore, their association with renal dysfunction is likely related to endothelial injury, inflammation and oxidative stress.2021-05-282021-05-28T00:00:00Z2024-05-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/134564TID:202847730engÁlvaro Alexandre Ferreira Duarteinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:15:21Zoai:repositorio-aberto.up.pt:10216/134564Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:36:45.319132Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
title |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
spellingShingle |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. Álvaro Alexandre Ferreira Duarte Medicina clínica Clinical medicine |
title_short |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
title_full |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
title_fullStr |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
title_full_unstemmed |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
title_sort |
Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress. |
author |
Álvaro Alexandre Ferreira Duarte |
author_facet |
Álvaro Alexandre Ferreira Duarte |
author_role |
author |
dc.contributor.author.fl_str_mv |
Álvaro Alexandre Ferreira Duarte |
dc.subject.por.fl_str_mv |
Medicina clínica Clinical medicine |
topic |
Medicina clínica Clinical medicine |
description |
Introduction and objectives: Acute heart failure (AHF) and cardiogenic shock (CS) are associated with high hospitalization and mortality rates. Renin-angiotensin-aldosterone system (RAAS) activation and redox dysfunction contribute to cardiac and renal dysfunction, but their interplay in human AHF and CS has not been explored. We aimed to investigate plasma and urinary angiotensinogen (P-AGT; U-AGT, an intrarenal RAAS marker) and urinary H2O2 (U-H2O2) in AHF and CS patients. Furthermore, we evaluated the correlations between them, as well as their association with endothelial dysfunction, inflammation, oxidative stress and cardiac and renal impairment. Methods: Patients with AHF (n=23) or CS (n=25) and healthy controls (n=22) were included. U-AGT, P-AGT, U-H2O2, endothelial dysfunction, inflammation, oxidative stress and cardiac/renal impairment markers were evaluated at days 1-2 (admission), days 3-4 and days 5-8 in AHF and CS patients and at a single time point in controls. Results: At admission, AHF and CS patients had similar P-AGT, higher U-AGT and lower U-H2O2 than controls. There were no changes in P-AGT, U-AGT or U-H2O2 along hospitalization. P-AGT and U-AGT positively correlated with endothelial dysfunction, inflammation and oxidative stress, while U-H2O2 negatively correlated with these biomarkers and with U-AGT in the overall study population. Among patients, U-H2O2 positively correlated with inflammation, oxidative stress and P-AGT, and both U-AGT and U-H2O2 were associated with renal impairment. Conclusions: AHF and CS patients appear to have intrarenal RAAS activation and increased H2O2 consumption, probably by myeloperoxidase. Furthermore, their association with renal dysfunction is likely related to endothelial injury, inflammation and oxidative stress. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-28 2021-05-28T00:00:00Z 2024-05-27T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
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https://hdl.handle.net/10216/134564 TID:202847730 |
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https://hdl.handle.net/10216/134564 |
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TID:202847730 |
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eng |
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eng |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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