The right time for senescence

Detalhes bibliográficos
Autor(a) principal: Paramos-de-Carvalho, Diogo
Data de Publicação: 2021
Outros Autores: Jacinto, Antonio, Saúde, Leonor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50314
Resumo: © Paramos de Carvalho et al. Copyright Paramos-de-Carvalho et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited
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spelling The right time for senescenceCell biologyPathophysiologySenescenceSenotherapiesTimeTissue remodelling© Paramos de Carvalho et al. Copyright Paramos-de-Carvalho et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are creditedCellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how "time" seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field.This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC/MED-NEU/30428/2017), 'la Caixa' Banking Foundation and FCT, IP, under project code HR18-00187 and SCML Melo e Castro Award (MC36-2020).eLifeRepositório da Universidade de LisboaParamos-de-Carvalho, DiogoJacinto, AntonioSaúde, Leonor2021-12-09T15:30:40Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50314engParamos de Carvalho D, Jacinto A, Saúde L. The right time for senescence. Elife. 2021 Nov 10;10:e724492050-084X10.7554/eLife.72449info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:26Zoai:repositorio.ul.pt:10451/50314Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:47.903930Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The right time for senescence
title The right time for senescence
spellingShingle The right time for senescence
Paramos-de-Carvalho, Diogo
Cell biology
Pathophysiology
Senescence
Senotherapies
Time
Tissue remodelling
title_short The right time for senescence
title_full The right time for senescence
title_fullStr The right time for senescence
title_full_unstemmed The right time for senescence
title_sort The right time for senescence
author Paramos-de-Carvalho, Diogo
author_facet Paramos-de-Carvalho, Diogo
Jacinto, Antonio
Saúde, Leonor
author_role author
author2 Jacinto, Antonio
Saúde, Leonor
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Paramos-de-Carvalho, Diogo
Jacinto, Antonio
Saúde, Leonor
dc.subject.por.fl_str_mv Cell biology
Pathophysiology
Senescence
Senotherapies
Time
Tissue remodelling
topic Cell biology
Pathophysiology
Senescence
Senotherapies
Time
Tissue remodelling
description © Paramos de Carvalho et al. Copyright Paramos-de-Carvalho et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited
publishDate 2021
dc.date.none.fl_str_mv 2021-12-09T15:30:40Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50314
url http://hdl.handle.net/10451/50314
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Paramos de Carvalho D, Jacinto A, Saúde L. The right time for senescence. Elife. 2021 Nov 10;10:e72449
2050-084X
10.7554/eLife.72449
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv eLife
publisher.none.fl_str_mv eLife
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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