Candida auris in Intensive Care Setting: The First Case Reported in Portugal

Detalhes bibliográficos
Autor(a) principal: Henriques, João
Data de Publicação: 2023
Outros Autores: Mixão, Verónica, Cabrita, Joana, Duarte, Tiago Isidoro, Sequeira, Tânia, Cardoso, Sofia, Germano, Nuno, Dias, Liliana, Bento, Luís, Duarte, Sílvia, Veríssimo, Cristina, Gomes, João Paulo, Sabino, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8971
Resumo: (This article belongs to the Special Issue Genomic Epidemiology of Fungal Diseases 2023)
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spelling Candida auris in Intensive Care Setting: The First Case Reported in PortugalCandida aurisAntifungal ResistanceWhole-genome SequencingFungal DiseasesInfecções Sistémicas e ZoonosesPortugal(This article belongs to the Special Issue Genomic Epidemiology of Fungal Diseases 2023)Candida auris is an opportunistic human pathogen that has rapidly spread to multiple countries and continents and has been associated with a high number of nosocomial outbreaks. Herein, we report the first case of C. auris in Portugal, which was associated with a patient transferred from Angola to an ICU in Portugal for liver transplantation after a SARS-CoV-2 infection. C. auris was isolated during the course of bronchoalveolar lavage, and it was subjected to antifungal susceptibility testing and whole-genome sequence analysis. This isolate presents low susceptibility to azoles and belongs to the genetic clade III with a phylogenetic placement close to African isolates. Although clade III has already been reported in Europe, taking into account the patient's clinical history, we cannot discard the possibility that the patient's colonization/infection occurred in Angola, prior to admission in the Portuguese hospital. Considering that C. auris is a fungal pathogen referenced by WHO as a critical priority, this case reinforces the need for continuous surveillance in a hospital setting.This work was supported by funding from the European Union EU4Health Programme under grant agreement no. 101113460 (GENEO) and by national funds through the Foundation for Science and Technology (FCT), I.P., under Individual CEEC 2022.00851.CEECIND/CP1748/CT0001MDPIRepositório Científico do Instituto Nacional de SaúdeHenriques, JoãoMixão, VerónicaCabrita, JoanaDuarte, Tiago IsidoroSequeira, TâniaCardoso, SofiaGermano, NunoDias, LilianaBento, LuísDuarte, SílviaVeríssimo, CristinaGomes, João PauloSabino, Raquel2024-01-24T16:13:27Z2023-08-092023-08-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8971engJ Fungi (Basel). 2023 Aug 9;9(8):837. doi: 10.3390/jof90808372309-608X10.3390/jof9080837info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-27T01:31:54Zoai:repositorio.insa.pt:10400.18/8971Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:57:59.493274Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Candida auris in Intensive Care Setting: The First Case Reported in Portugal
title Candida auris in Intensive Care Setting: The First Case Reported in Portugal
spellingShingle Candida auris in Intensive Care Setting: The First Case Reported in Portugal
Henriques, João
Candida auris
Antifungal Resistance
Whole-genome Sequencing
Fungal Diseases
Infecções Sistémicas e Zoonoses
Portugal
title_short Candida auris in Intensive Care Setting: The First Case Reported in Portugal
title_full Candida auris in Intensive Care Setting: The First Case Reported in Portugal
title_fullStr Candida auris in Intensive Care Setting: The First Case Reported in Portugal
title_full_unstemmed Candida auris in Intensive Care Setting: The First Case Reported in Portugal
title_sort Candida auris in Intensive Care Setting: The First Case Reported in Portugal
author Henriques, João
author_facet Henriques, João
Mixão, Verónica
Cabrita, Joana
Duarte, Tiago Isidoro
Sequeira, Tânia
Cardoso, Sofia
Germano, Nuno
Dias, Liliana
Bento, Luís
Duarte, Sílvia
Veríssimo, Cristina
Gomes, João Paulo
Sabino, Raquel
author_role author
author2 Mixão, Verónica
Cabrita, Joana
Duarte, Tiago Isidoro
Sequeira, Tânia
Cardoso, Sofia
Germano, Nuno
Dias, Liliana
Bento, Luís
Duarte, Sílvia
Veríssimo, Cristina
Gomes, João Paulo
Sabino, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Henriques, João
Mixão, Verónica
Cabrita, Joana
Duarte, Tiago Isidoro
Sequeira, Tânia
Cardoso, Sofia
Germano, Nuno
Dias, Liliana
Bento, Luís
Duarte, Sílvia
Veríssimo, Cristina
Gomes, João Paulo
Sabino, Raquel
dc.subject.por.fl_str_mv Candida auris
Antifungal Resistance
Whole-genome Sequencing
Fungal Diseases
Infecções Sistémicas e Zoonoses
Portugal
topic Candida auris
Antifungal Resistance
Whole-genome Sequencing
Fungal Diseases
Infecções Sistémicas e Zoonoses
Portugal
description (This article belongs to the Special Issue Genomic Epidemiology of Fungal Diseases 2023)
publishDate 2023
dc.date.none.fl_str_mv 2023-08-09
2023-08-09T00:00:00Z
2024-01-24T16:13:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8971
url http://hdl.handle.net/10400.18/8971
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Fungi (Basel). 2023 Aug 9;9(8):837. doi: 10.3390/jof9080837
2309-608X
10.3390/jof9080837
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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