MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance

Detalhes bibliográficos
Autor(a) principal: Esteves, João Victor
Data de Publicação: 2017
Outros Autores: Enguita, Francisco J., Machado, Ubiratan Fabres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51419
Resumo: Copyright © 2017 João Victor Esteves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistanceCopyright © 2017 João Victor Esteves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The solute carrier family 2 facilitated glucose transporter member 4 (GLUT4) plays a key role in the insulin-induced glucose uptake by muscle and adipose tissues. In prediabetes and diabetes, GLUT4 expression/translocation has been detected as reduced, participating in mechanisms that impair glycemic control. Recently, a class of short endogenous noncoding RNAs named microRNAs (miRNAs) has been increasingly described as involved in the posttranscriptional epigenetic regulation of gene expression. The present review focuses on miRNAs potentially involved in the expression of GLUT4 expression, and proteins related to GLUT4 and translocation in skeletal muscle, seeking to correlate them with insulin resistance and diabetes. So far, miR-21a-5p, miR-29a-3p, miR-29c-3p, miR-93-5p, miR-106b-5p, miR-133a-3p, miR-133b-3p, miR-222-3p, and miR-223-3p have been reported to directly and/or indirectly regulate the GLUT4 expression; and their expression is altered under diabetes-related conditions. Besides, some miRNAs that have been linked to the expression of proteins involved in GLUT4 translocation machinery in muscle could also impact glucose uptake. That makes these miRNAs promising targets for preventive and/or therapeutic approaches, which could improve glycemic control, thus deserving future new investigations.J. V. Esteves was recipient of FAPESP Fellowship #2012/20432-0.HindawiRepositório da Universidade de LisboaEsteves, João VictorEnguita, Francisco J.Machado, Ubiratan Fabres2022-02-18T15:45:46Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51419engJ Diabetes Res. 2017;2017:7267910.2314-674510.1155/2017/72679102314-6753info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:04Zoai:repositorio.ul.pt:10451/51419Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:41.255533Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
title MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
spellingShingle MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
Esteves, João Victor
title_short MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
title_full MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
title_fullStr MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
title_full_unstemmed MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
title_sort MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance
author Esteves, João Victor
author_facet Esteves, João Victor
Enguita, Francisco J.
Machado, Ubiratan Fabres
author_role author
author2 Enguita, Francisco J.
Machado, Ubiratan Fabres
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Esteves, João Victor
Enguita, Francisco J.
Machado, Ubiratan Fabres
description Copyright © 2017 João Victor Esteves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2022-02-18T15:45:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51419
url http://hdl.handle.net/10451/51419
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Diabetes Res. 2017;2017:7267910.
2314-6745
10.1155/2017/7267910
2314-6753
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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