Enhanced photodynamic therapy: a review of combined energy sources

Detalhes bibliográficos
Autor(a) principal: Rodrigues, José Artur Oliveira
Data de Publicação: 2022
Outros Autores: Correia, J. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/82947
Resumo: Photodynamic therapy (PDT) has been used in recent years as a non-invasive treatment for cancer, due to the side effects of traditional treatments such as surgery, radiotherapy, and chemother apy. This therapeutic technique requires a photosensitizer, light energy, and oxygen to produce reactive oxygen species (ROS) which mediate cellular toxicity. PDT is a useful non-invasive therapy for cancer treatment, but it has some limitations that need to be overcome, such as low-light-penetration depths, non-targeting photosensitizers, and tumor hypoxia. This review focuses on the latest innovative strategies based on the synergistic use of other energy sources, such as non-visible radiation of the electromagnetic spectrum (microwaves, infrared, and X-rays), ultrasound, and electric/magnetic fields, to overcome PDT limitations and enhance the therapeutic effect of PDT. The main principles, mechanisms, and crucial elements of PDT are also addressed
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spelling Enhanced photodynamic therapy: a review of combined energy sourcesPhotodynamic therapyNon-visible radiationUltrasoundElectric fieldMagnetic fieldSynergistic strategiesScience & TechnologyPhotodynamic therapy (PDT) has been used in recent years as a non-invasive treatment for cancer, due to the side effects of traditional treatments such as surgery, radiotherapy, and chemother apy. This therapeutic technique requires a photosensitizer, light energy, and oxygen to produce reactive oxygen species (ROS) which mediate cellular toxicity. PDT is a useful non-invasive therapy for cancer treatment, but it has some limitations that need to be overcome, such as low-light-penetration depths, non-targeting photosensitizers, and tumor hypoxia. This review focuses on the latest innovative strategies based on the synergistic use of other energy sources, such as non-visible radiation of the electromagnetic spectrum (microwaves, infrared, and X-rays), ultrasound, and electric/magnetic fields, to overcome PDT limitations and enhance the therapeutic effect of PDT. The main principles, mechanisms, and crucial elements of PDT are also addressedThis work was supported by project MME reference 105399; CMEMS-UMinho Strategic Project UIDB/04436/2020 and UIDP/04436/2020; Infrastructures Micro&NanoFabs@PT, NORTE-01-0145-FEDER-022090, Portugal 2020; and MPhotonBiopsy, PTDC/FIS-OTI/1259/2020MDPIUniversidade do MinhoRodrigues, José Artur OliveiraCorreia, J. H.20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/82947engRodrigues, J.A.; Correia, J.H. Enhanced Photodynamic Therapy: A Review of Combined Energy Sources. Cells 2022, 11, 3995. https://doi.org/10.3390/cells112439952073-440910.3390/cells1124399536552759https://www.mdpi.com/2073-4409/11/24/3995info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-23T01:29:20Zoai:repositorium.sdum.uminho.pt:1822/82947Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:52.548889Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Enhanced photodynamic therapy: a review of combined energy sources
title Enhanced photodynamic therapy: a review of combined energy sources
spellingShingle Enhanced photodynamic therapy: a review of combined energy sources
Rodrigues, José Artur Oliveira
Photodynamic therapy
Non-visible radiation
Ultrasound
Electric field
Magnetic field
Synergistic strategies
Science & Technology
title_short Enhanced photodynamic therapy: a review of combined energy sources
title_full Enhanced photodynamic therapy: a review of combined energy sources
title_fullStr Enhanced photodynamic therapy: a review of combined energy sources
title_full_unstemmed Enhanced photodynamic therapy: a review of combined energy sources
title_sort Enhanced photodynamic therapy: a review of combined energy sources
author Rodrigues, José Artur Oliveira
author_facet Rodrigues, José Artur Oliveira
Correia, J. H.
author_role author
author2 Correia, J. H.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, José Artur Oliveira
Correia, J. H.
dc.subject.por.fl_str_mv Photodynamic therapy
Non-visible radiation
Ultrasound
Electric field
Magnetic field
Synergistic strategies
Science & Technology
topic Photodynamic therapy
Non-visible radiation
Ultrasound
Electric field
Magnetic field
Synergistic strategies
Science & Technology
description Photodynamic therapy (PDT) has been used in recent years as a non-invasive treatment for cancer, due to the side effects of traditional treatments such as surgery, radiotherapy, and chemother apy. This therapeutic technique requires a photosensitizer, light energy, and oxygen to produce reactive oxygen species (ROS) which mediate cellular toxicity. PDT is a useful non-invasive therapy for cancer treatment, but it has some limitations that need to be overcome, such as low-light-penetration depths, non-targeting photosensitizers, and tumor hypoxia. This review focuses on the latest innovative strategies based on the synergistic use of other energy sources, such as non-visible radiation of the electromagnetic spectrum (microwaves, infrared, and X-rays), ultrasound, and electric/magnetic fields, to overcome PDT limitations and enhance the therapeutic effect of PDT. The main principles, mechanisms, and crucial elements of PDT are also addressed
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/82947
url https://hdl.handle.net/1822/82947
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, J.A.; Correia, J.H. Enhanced Photodynamic Therapy: A Review of Combined Energy Sources. Cells 2022, 11, 3995. https://doi.org/10.3390/cells11243995
2073-4409
10.3390/cells11243995
36552759
https://www.mdpi.com/2073-4409/11/24/3995
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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