Enzymatic vitreolysis for the treatment of tractional diabetic macular edema

Detalhes bibliográficos
Autor(a) principal: Pessoa, Bernardete
Data de Publicação: 2019
Outros Autores: Coelho, João, Coelho, Constança, Monteiro, Sílvia, Abreu, Carolina, Figueira, João, Meireles, Angelina, Melo Beirão, João Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/39658
Resumo: © The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissions
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spelling Enzymatic vitreolysis for the treatment of tractional diabetic macular edemaAnti-vascular endothelial growth factor injectionsDiabetic macular edemaOcriplasminVitreolysisVitreomacular traction© The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissionsBackground: A new approach to address focal vitreomacular adhesion in patients with diabetic macular edema may control and stabilize diabetic macular edema with fewer antivascular endothelial growth factor injections. Objectives: The aim of this study was to demonstrate that diabetic macular edema can be improved by inducing the release of a vitreomacular adhesion, with less than 2500μm, with enzymatic vitreolysis. Methods: From a retrospective analysis of clinical records from patients with diabetic retinopathy, patients with diabetic macular edema and vitreomacular adhesion <2500μm were selected for a single-arm prospective study. The primary endpoint was to control diabetic macular edema with fewer anti-vascular endothelial growth factor injections after an observed vitreomacular adhesion release. A statistical subanalysis was performed for the following two groups: the group with vitreomacular adhesion release (group 1) and the group without vitreomacular adhesion release (group 2). Results: A total of 23 eyes from 19 patients were included. A reduction of the median number of injections was achieved in group 1 (p=0.006). Adverse events were mild and transitory. Conclusion: Release of vitreomacular adhesion <2500μm through enzymatic vitreolysis contributed to the control and stabilization of diabetic macular edema with fewer anti-vascular endothelial growth factor injections, reducing the burden and the risks related to these invasive and frequently chronic treatments.SAGE PublicationsRepositório da Universidade de LisboaPessoa, BernardeteCoelho, JoãoCoelho, ConstançaMonteiro, SílviaAbreu, CarolinaFigueira, JoãoMeireles, AngelinaMelo Beirão, João Nuno2019-09-30T15:37:02Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/39658engTher Adv Ophthalmol 2019, Vol. 11: 1–102515-841410.1177/ 2515841419869511info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:38:34Zoai:repositorio.ul.pt:10451/39658Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:53:30.801711Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
title Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
spellingShingle Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
Pessoa, Bernardete
Anti-vascular endothelial growth factor injections
Diabetic macular edema
Ocriplasmin
Vitreolysis
Vitreomacular traction
title_short Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
title_full Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
title_fullStr Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
title_full_unstemmed Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
title_sort Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
author Pessoa, Bernardete
author_facet Pessoa, Bernardete
Coelho, João
Coelho, Constança
Monteiro, Sílvia
Abreu, Carolina
Figueira, João
Meireles, Angelina
Melo Beirão, João Nuno
author_role author
author2 Coelho, João
Coelho, Constança
Monteiro, Sílvia
Abreu, Carolina
Figueira, João
Meireles, Angelina
Melo Beirão, João Nuno
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pessoa, Bernardete
Coelho, João
Coelho, Constança
Monteiro, Sílvia
Abreu, Carolina
Figueira, João
Meireles, Angelina
Melo Beirão, João Nuno
dc.subject.por.fl_str_mv Anti-vascular endothelial growth factor injections
Diabetic macular edema
Ocriplasmin
Vitreolysis
Vitreomacular traction
topic Anti-vascular endothelial growth factor injections
Diabetic macular edema
Ocriplasmin
Vitreolysis
Vitreomacular traction
description © The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissions
publishDate 2019
dc.date.none.fl_str_mv 2019-09-30T15:37:02Z
2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/39658
url http://hdl.handle.net/10451/39658
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ther Adv Ophthalmol 2019, Vol. 11: 1–10
2515-8414
10.1177/ 2515841419869511
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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