Tolerogenic insulin peptide therapy precipitates type 1 diabetes

Detalhes bibliográficos
Autor(a) principal: Bergman, Marie-Louise
Data de Publicação: 2017
Outros Autores: Lopes-Carvalho, Thiago, Martins, Ana-Catarina, Grieco, Fabio A., Eizirik, Décio L., Demengeot, Jocelyne
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/819
Resumo: Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.
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spelling Tolerogenic insulin peptide therapy precipitates type 1 diabetesAutoimmunitydiabetesinsulinVaccinationDaniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.Rockefeller University PressARCABergman, Marie-LouiseLopes-Carvalho, ThiagoMartins, Ana-CatarinaGrieco, Fabio A.Eizirik, Décio L.Demengeot, Jocelyne2017-12-07T16:27:54Z2017-05-232017-05-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/819eng10.1084/jem.20160471info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:20:32Zoai:arca.igc.gulbenkian.pt:10400.7/819Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:20:32Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title Tolerogenic insulin peptide therapy precipitates type 1 diabetes
spellingShingle Tolerogenic insulin peptide therapy precipitates type 1 diabetes
Bergman, Marie-Louise
Autoimmunity
diabetes
insulin
Vaccination
title_short Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_full Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_fullStr Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_full_unstemmed Tolerogenic insulin peptide therapy precipitates type 1 diabetes
title_sort Tolerogenic insulin peptide therapy precipitates type 1 diabetes
author Bergman, Marie-Louise
author_facet Bergman, Marie-Louise
Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
author_role author
author2 Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Bergman, Marie-Louise
Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
dc.subject.por.fl_str_mv Autoimmunity
diabetes
insulin
Vaccination
topic Autoimmunity
diabetes
insulin
Vaccination
description Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-07T16:27:54Z
2017-05-23
2017-05-23T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/819
url http://hdl.handle.net/10400.7/819
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1084/jem.20160471
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Rockefeller University Press
publisher.none.fl_str_mv Rockefeller University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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