Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Malpetti, Maura; Jones, P. Simon; Tsvetanov, Kamen A.; Rittman, Timothy; Swieten, John C.; Borroni, Barbara; Sanchez‐Valle, Raquel; Moreno, Fermin; Laforce, Robert; Graff, Caroline; Synofzik, Matthis; Galimberti, Daniela; Masellis, Mario; Tartaglia, Maria Carmela; Finger, Elizabeth; Vandenberghe, Rik; Mendonça, Alexandre de; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Chris R.; Gerhard, Alexander; Levin, Johannes; Danek, Adrian; Otto, Markus; Frisoni, Giovanni B.; Ghidoni, Roberta; Sorbi, Sandro; Heller, Carolin; Todd, Emily G.; Bocchetta, Martina; Cash, David M.; Convery, Rhian S.; Peakman, Georgia; Moore, Katrina M.; Rohrer, Jonathan D.; Kievit, Rogier A.; Rowe, James B.; GENFI - Genetic Frontotemporal dementia Initiative

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Detalhes bibliográficos
Autor(a) principal:	Malpetti, Maura
Data de Publicação:	2020
Outros Autores:	Jones, P. Simon, Tsvetanov, Kamen A., Rittman, Timothy, Swieten, John C., Borroni, Barbara, Sanchez‐Valle, Raquel, Moreno, Fermin, Laforce, Robert, Graff, Caroline, Synofzik, Matthis, Galimberti, Daniela, Masellis, Mario, Tartaglia, Maria Carmela, Finger, Elizabeth, Vandenberghe, Rik, Mendonça, Alexandre de, Tagliavini, Fabrizio, Santana, Isabel, Ducharme, Simon, Butler, Chris R., Gerhard, Alexander, Levin, Johannes, Danek, Adrian, Otto, Markus, Frisoni, Giovanni B., Ghidoni, Roberta, Sorbi, Sandro, Heller, Carolin, Todd, Emily G., Bocchetta, Martina, Cash, David M., Convery, Rhian S., Peakman, Georgia, Moore, Katrina M., Rohrer, Jonathan D., Kievit, Rogier A., Rowe, James B., GENFI - Genetic Frontotemporal dementia Initiative
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10451/45431
Resumo:	© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Metadados do item

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network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changesApathyCognitive declineGenetic frontotemporal dementiaLongitudinal designMRIPresymptomatic carriers© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Introduction: Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy. Methods: Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling. Results: Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions. Discussion: Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD.This work is co‐funded by the UK Medical Research Council (MR/M023664/1), the Italian Ministry of Health and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, a Canadian Institutes of Health Research operating grant and the Bluefield Project, as well as a JPND grant “GENFI‐prox” (by DLR/BMBF to MS, joined with JDR, JvS, MO, BB and CG). MM is supported by the Cambridge Trust & Sidney Sussex College Scholarship. PSJ is supported by the Cambridge Centre for Parkinson Plus. KAT is supported by the British Academy Postdoctoral Fellowship (KAT: PF160048) and Guarantors of Brain (KAT: 101149). TR is supported by the Cambridge Centre for Parkinson Plus and Cambridge Biomedical Resource Centre. RAK is supported by Medical Research Council (RAK: SUAG/047/G101400). JBR reports grants from the NIHR Cambridge Biomedical research centre, Wellcome Trust (103838), and Medical Research Council (SUAG051/G101400; MR/T033371/1); personal fees from Asceneuron, WAVE, Astex, and Biogen; and grants from Janssen, AZ Medimmune, and Eli Lilly, outside the submitted work. JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). MB is supported by a Fellowship award from the Alzheimer's Society, UK (AS‐JF‐19a‐004‐517), and by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK.John Wiley & Sons, Inc.Repositório da Universidade de LisboaMalpetti, MauraJones, P. SimonTsvetanov, Kamen A.Rittman, TimothySwieten, John C.Borroni, BarbaraSanchez‐Valle, RaquelMoreno, FerminLaforce, RobertGraff, CarolineSynofzik, MatthisGalimberti, DanielaMasellis, MarioTartaglia, Maria CarmelaFinger, ElizabethVandenberghe, RikMendonça, Alexandre deTagliavini, FabrizioSantana, IsabelDucharme, SimonButler, Chris R.Gerhard, AlexanderLevin, JohannesDanek, AdrianOtto, MarkusFrisoni, Giovanni B.Ghidoni, RobertaSorbi, SandroHeller, CarolinTodd, Emily G.Bocchetta, MartinaCash, David M.Convery, Rhian S.Peakman, GeorgiaMoore, Katrina M.Rohrer, Jonathan D.Kievit, Rogier A.Rowe, James B.GENFI - Genetic Frontotemporal dementia Initiative2020-12-17T17:29:05Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45431engAlzheimer’s Dement. 2020;00-00.1552-526010.1002/alz.122522352-8729info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:47:17Zoai:repositorio.ul.pt:10451/45431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:57:52.545650Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
title	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
spellingShingle	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes Malpetti, Maura Apathy Cognitive decline Genetic frontotemporal dementia Longitudinal design MRI Presymptomatic carriers
title_short	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
title_full	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
title_fullStr	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
title_full_unstemmed	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
title_sort	Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
author	Malpetti, Maura
author_facet	Malpetti, Maura Jones, P. Simon Tsvetanov, Kamen A. Rittman, Timothy Swieten, John C. Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik Mendonça, Alexandre de Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Levin, Johannes Danek, Adrian Otto, Markus Frisoni, Giovanni B. Ghidoni, Roberta Sorbi, Sandro Heller, Carolin Todd, Emily G. Bocchetta, Martina Cash, David M. Convery, Rhian S. Peakman, Georgia Moore, Katrina M. Rohrer, Jonathan D. Kievit, Rogier A. Rowe, James B. GENFI - Genetic Frontotemporal dementia Initiative
author_role	author
author2	Jones, P. Simon Tsvetanov, Kamen A. Rittman, Timothy Swieten, John C. Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik Mendonça, Alexandre de Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Levin, Johannes Danek, Adrian Otto, Markus Frisoni, Giovanni B. Ghidoni, Roberta Sorbi, Sandro Heller, Carolin Todd, Emily G. Bocchetta, Martina Cash, David M. Convery, Rhian S. Peakman, Georgia Moore, Katrina M. Rohrer, Jonathan D. Kievit, Rogier A. Rowe, James B. GENFI - Genetic Frontotemporal dementia Initiative
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv	Malpetti, Maura Jones, P. Simon Tsvetanov, Kamen A. Rittman, Timothy Swieten, John C. Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik Mendonça, Alexandre de Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Levin, Johannes Danek, Adrian Otto, Markus Frisoni, Giovanni B. Ghidoni, Roberta Sorbi, Sandro Heller, Carolin Todd, Emily G. Bocchetta, Martina Cash, David M. Convery, Rhian S. Peakman, Georgia Moore, Katrina M. Rohrer, Jonathan D. Kievit, Rogier A. Rowe, James B. GENFI - Genetic Frontotemporal dementia Initiative
dc.subject.por.fl_str_mv	Apathy Cognitive decline Genetic frontotemporal dementia Longitudinal design MRI Presymptomatic carriers
topic	Apathy Cognitive decline Genetic frontotemporal dementia Longitudinal design MRI Presymptomatic carriers
description	© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate	2020
dc.date.none.fl_str_mv	2020-12-17T17:29:05Z 2020 2020-01-01T00:00:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10451/45431
url	http://hdl.handle.net/10451/45431
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Alzheimer’s Dement. 2020;00-00. 1552-5260 10.1002/alz.12252 2352-8729
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	John Wiley & Sons, Inc.
publisher.none.fl_str_mv	John Wiley & Sons, Inc.
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

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