Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/103791 |
Resumo: | 57763]. AS is supported by a doctoral grant from “Fundação para a Ciência e Tecnologia” (SFRH/BD/108246/2015). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritisIs the reason to switch relevant?Ankylosing spondylitisASaxSpAbDMARDnr-axSpAr-axSpASpondyloarthritisSwitchTNFiTreatmentRheumatologyImmunology and AllergyImmunology57763]. AS is supported by a doctoral grant from “Fundação para a Ciência e Tecnologia” (SFRH/BD/108246/2015).Background: To investigate whether the reason to discontinue the first TNF inhibitor (TNFi) affects the response to the second TNFi in axial spondyloarthritis (axSpA). Methods: Patients with axSpA from the Rheumatic Diseases Portuguese Register (ReumaPt), who discontinued their first TNFi and started the second TNFi between June 2008 and May 2018, were included. Response was assessed by the Ankylosing Spondylitis Disease Activity Score (ASDAS) clinically important improvement (ASDAS-CII), major important improvement (ASDAS-MI), low disease activity (ASDAS-LDA), and inactive disease (ASDAS-ID). The reason for discontinuation of the first TNFi was defined, according to ASDAS-CII as primary failure (no response ≤ 6 months), secondary failure (response ≤ 6 months but lost thereafter), adverse events, and others. The association between the reason for discontinuation of the first TNFi and response to the second TNFi over time was assessed in multivariable generalized equation (GEE) models. Results: In total, 193 patients were included. The reason for discontinuation of the first TNFi did not influence the response to the second TNFi, according to the ASDAS-CII. However, a difference was found with more stringent outcomes, e.g., there was a higher likelihood to achieve ASDAS-ID with the second TNFi for patients discontinuing the first TNFi due to secondary failure (OR 7.3 [95%CI 1.9; 27.7]), adverse events (OR 9.1 [2.5; 33.3]), or other reasons (OR 7.7 [1.6; 37.9]) compared to primary failure. Conclusion: Patients with axSpA with secondary failure to their first TNFi, compared to those with primary failure, have a better response to the second TNFi according to stringent outcomes.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNManica, Santiago RodriguesSepriano, AlexandrePimentel-Santos, FernandoGouveia, NéliaBarcelos, AnabelaBranco, JaimeBernardes, MiguelFerreira, Raquel MiriamVieira-Sousa, ElsaBarreira, SofiaVinagre, FilipeRoque, RaquelSantos, HelenaMadeira, NathalieRovisco, JoãoDaniel, AlexandraRamiro, Sofia2020-09-09T02:37:28Z2020-08-212020-08-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/103791eng1478-6354PURE: 19742660https://doi.org/10.1186/s13075-020-02288-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:49:26Zoai:run.unl.pt:10362/103791Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:04.173741Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis Is the reason to switch relevant? |
| title |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis |
| spellingShingle |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis Manica, Santiago Rodrigues Ankylosing spondylitis AS axSpA bDMARD nr-axSpA r-axSpA Spondyloarthritis Switch TNFi Treatment Rheumatology Immunology and Allergy Immunology |
| title_short |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis |
| title_full |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis |
| title_fullStr |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis |
| title_full_unstemmed |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis |
| title_sort |
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis |
| author |
Manica, Santiago Rodrigues |
| author_facet |
Manica, Santiago Rodrigues Sepriano, Alexandre Pimentel-Santos, Fernando Gouveia, Nélia Barcelos, Anabela Branco, Jaime Bernardes, Miguel Ferreira, Raquel Miriam Vieira-Sousa, Elsa Barreira, Sofia Vinagre, Filipe Roque, Raquel Santos, Helena Madeira, Nathalie Rovisco, João Daniel, Alexandra Ramiro, Sofia |
| author_role |
author |
| author2 |
Sepriano, Alexandre Pimentel-Santos, Fernando Gouveia, Nélia Barcelos, Anabela Branco, Jaime Bernardes, Miguel Ferreira, Raquel Miriam Vieira-Sousa, Elsa Barreira, Sofia Vinagre, Filipe Roque, Raquel Santos, Helena Madeira, Nathalie Rovisco, João Daniel, Alexandra Ramiro, Sofia |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Manica, Santiago Rodrigues Sepriano, Alexandre Pimentel-Santos, Fernando Gouveia, Nélia Barcelos, Anabela Branco, Jaime Bernardes, Miguel Ferreira, Raquel Miriam Vieira-Sousa, Elsa Barreira, Sofia Vinagre, Filipe Roque, Raquel Santos, Helena Madeira, Nathalie Rovisco, João Daniel, Alexandra Ramiro, Sofia |
| dc.subject.por.fl_str_mv |
Ankylosing spondylitis AS axSpA bDMARD nr-axSpA r-axSpA Spondyloarthritis Switch TNFi Treatment Rheumatology Immunology and Allergy Immunology |
| topic |
Ankylosing spondylitis AS axSpA bDMARD nr-axSpA r-axSpA Spondyloarthritis Switch TNFi Treatment Rheumatology Immunology and Allergy Immunology |
| description |
57763]. AS is supported by a doctoral grant from “Fundação para a Ciência e Tecnologia” (SFRH/BD/108246/2015). |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-09-09T02:37:28Z 2020-08-21 2020-08-21T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/103791 |
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http://hdl.handle.net/10362/103791 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1478-6354 PURE: 19742660 https://doi.org/10.1186/s13075-020-02288-8 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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