Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/164615 |
Resumo: | Funding Information: This research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) [Finance Code 001 and 88881.130749/2016-01], Conselho Nacional de Desenvolvimento Científico e Tecnológico [439967/2016-3, 400830/2013-2, 440891/2016-7 and 311365/2021-3], Programa de Excelência em Pesquisa [420765/2017-4], Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ZIKA—0416006000] and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [PET0026/2013, APP0044/2016, and PET0022/2016]. L.M. received a Ph.D. scholarship from CAPES. R.K., G.S.R., V.B., M.G.R., A.B., and M.B.-N. are CNPq fellows. The funding organizations had no role in the study design, data collection, data interpretation, or writing of this report. B.V. was supported by a postdoctoral grant (12U7121N) of the Research Foundation—Flanders (Fonds voor Wetenschappelijk Onderzoek). P.L. acknowledges support by the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725422-ReservoirDOCS), from the Wellcome Trust through project 206298/Z/17/Z and from the Research Foundation—Flanders (Fonds voor Wetenschappelijk Onderzoek—Vlaanderen, G0D5117N, and G051322N). Publisher Copyright: © 2023 by the authors. |
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Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americasarbovirusesgenomic surveillancephylogeneticsvector-borne infectionsZikaQR MicrobiologyRA0421 Public health. Hygiene. Preventive MedicineInfectious DiseasesVirologyBiochemistry, Genetics and Molecular Biology (miscellaneous)EpidemiologySDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureFunding Information: This research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) [Finance Code 001 and 88881.130749/2016-01], Conselho Nacional de Desenvolvimento Científico e Tecnológico [439967/2016-3, 400830/2013-2, 440891/2016-7 and 311365/2021-3], Programa de Excelência em Pesquisa [420765/2017-4], Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ZIKA—0416006000] and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [PET0026/2013, APP0044/2016, and PET0022/2016]. L.M. received a Ph.D. scholarship from CAPES. R.K., G.S.R., V.B., M.G.R., A.B., and M.B.-N. are CNPq fellows. The funding organizations had no role in the study design, data collection, data interpretation, or writing of this report. B.V. was supported by a postdoctoral grant (12U7121N) of the Research Foundation—Flanders (Fonds voor Wetenschappelijk Onderzoek). P.L. acknowledges support by the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725422-ReservoirDOCS), from the Wellcome Trust through project 206298/Z/17/Z and from the Research Foundation—Flanders (Fonds voor Wetenschappelijk Onderzoek—Vlaanderen, G0D5117N, and G051322N). Publisher Copyright: © 2023 by the authors.The Americas, particularly Brazil, were greatly impacted by the widespread Zika virus (ZIKV) outbreak in 2015 and 2016. Efforts were made to implement genomic surveillance of ZIKV as part of the public health responses. The accuracy of spatiotemporal reconstructions of the epidemic spread relies on the unbiased sampling of the transmission process. In the early stages of the outbreak, we recruited patients exhibiting clinical symptoms of arbovirus-like infection from Salvador and Campo Formoso, Bahia, in Northeast Brazil. Between May 2015 and June 2016, we identified 21 cases of acute ZIKV infection and subsequently recovered 14 near full-length sequences using the amplicon tiling multiplex approach with nanopore sequencing. We performed a time-calibrated discrete phylogeographic analysis to trace the spread and migration history of the ZIKV. Our phylogenetic analysis supports a consistent relationship between ZIKV migration from Northeast to Southeast Brazil and its subsequent dissemination beyond Brazil. Additionally, our analysis provides insights into the migration of ZIKV from Brazil to Haiti and the role Brazil played in the spread of ZIKV to other countries, such as Singapore, the USA, and the Dominican Republic. The data generated by this study enhances our understanding of ZIKV dynamics and supports the existing knowledge, which can aid in future surveillance efforts against the virus.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)TB, HIV and opportunistic diseases and pathogens (THOP)RUNde Moraes, LaisePortilho, Moyra M.Vrancken, BramVan den Broeck, FrederikSantos, Luciane AmorimCucco, MarinaTauro, Laura B.Kikuti, MarianaSilva, Monaise M.O.Campos, Gúbio S.Reis, Mitermayer G.Barral, AldinaBarral-Netto, ManoelBoaventura, Viviane SampaioVandamme, Anne MiekeTheys, KristofLemey, PhilippeRibeiro, Guilherme S.Khouri, Ricardo2024-03-07T23:44:17Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/164615eng1999-4915PURE: 83057862https://doi.org/10.3390/v15061236info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:53:26Zoai:run.unl.pt:10362/164615Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:16.832928Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| title |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| spellingShingle |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas de Moraes, Laise arboviruses genomic surveillance phylogenetics vector-borne infections Zika QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine Infectious Diseases Virology Biochemistry, Genetics and Molecular Biology (miscellaneous) Epidemiology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| title_short |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| title_full |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| title_fullStr |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| title_full_unstemmed |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| title_sort |
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas |
| author |
de Moraes, Laise |
| author_facet |
de Moraes, Laise Portilho, Moyra M. Vrancken, Bram Van den Broeck, Frederik Santos, Luciane Amorim Cucco, Marina Tauro, Laura B. Kikuti, Mariana Silva, Monaise M.O. Campos, Gúbio S. Reis, Mitermayer G. Barral, Aldina Barral-Netto, Manoel Boaventura, Viviane Sampaio Vandamme, Anne Mieke Theys, Kristof Lemey, Philippe Ribeiro, Guilherme S. Khouri, Ricardo |
| author_role |
author |
| author2 |
Portilho, Moyra M. Vrancken, Bram Van den Broeck, Frederik Santos, Luciane Amorim Cucco, Marina Tauro, Laura B. Kikuti, Mariana Silva, Monaise M.O. Campos, Gúbio S. Reis, Mitermayer G. Barral, Aldina Barral-Netto, Manoel Boaventura, Viviane Sampaio Vandamme, Anne Mieke Theys, Kristof Lemey, Philippe Ribeiro, Guilherme S. Khouri, Ricardo |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) TB, HIV and opportunistic diseases and pathogens (THOP) RUN |
| dc.contributor.author.fl_str_mv |
de Moraes, Laise Portilho, Moyra M. Vrancken, Bram Van den Broeck, Frederik Santos, Luciane Amorim Cucco, Marina Tauro, Laura B. Kikuti, Mariana Silva, Monaise M.O. Campos, Gúbio S. Reis, Mitermayer G. Barral, Aldina Barral-Netto, Manoel Boaventura, Viviane Sampaio Vandamme, Anne Mieke Theys, Kristof Lemey, Philippe Ribeiro, Guilherme S. Khouri, Ricardo |
| dc.subject.por.fl_str_mv |
arboviruses genomic surveillance phylogenetics vector-borne infections Zika QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine Infectious Diseases Virology Biochemistry, Genetics and Molecular Biology (miscellaneous) Epidemiology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| topic |
arboviruses genomic surveillance phylogenetics vector-borne infections Zika QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine Infectious Diseases Virology Biochemistry, Genetics and Molecular Biology (miscellaneous) Epidemiology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| description |
Funding Information: This research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) [Finance Code 001 and 88881.130749/2016-01], Conselho Nacional de Desenvolvimento Científico e Tecnológico [439967/2016-3, 400830/2013-2, 440891/2016-7 and 311365/2021-3], Programa de Excelência em Pesquisa [420765/2017-4], Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ZIKA—0416006000] and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [PET0026/2013, APP0044/2016, and PET0022/2016]. L.M. received a Ph.D. scholarship from CAPES. R.K., G.S.R., V.B., M.G.R., A.B., and M.B.-N. are CNPq fellows. The funding organizations had no role in the study design, data collection, data interpretation, or writing of this report. B.V. was supported by a postdoctoral grant (12U7121N) of the Research Foundation—Flanders (Fonds voor Wetenschappelijk Onderzoek). P.L. acknowledges support by the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725422-ReservoirDOCS), from the Wellcome Trust through project 206298/Z/17/Z and from the Research Foundation—Flanders (Fonds voor Wetenschappelijk Onderzoek—Vlaanderen, G0D5117N, and G051322N). Publisher Copyright: © 2023 by the authors. |
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2023 |
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2023-06 2023-06-01T00:00:00Z 2024-03-07T23:44:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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eng |
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1999-4915 PURE: 83057862 https://doi.org/10.3390/v15061236 |
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