The association between stress and mood across the adult lifespan on default mode network

Detalhes bibliográficos
Autor(a) principal: Soares, José Miguel Montenegro
Data de Publicação: 2017
Outros Autores: Marques, Paulo César Gonçalves, Magalhães, Ricardo José Silva, Santos, Nadine Correia, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/49636
Resumo: Aging of brain structure and function is a complex process characterized by high inter- and intra-individual variability. Such variability may arise from the interaction of multiple factors, including exposure to stressful experience and mood variation, across the lifespan. Using a multimodal neuroimaging and neurocognitive approach, we investigated the association of stress, mood and their interaction, in the structure and function of the default mode network (DMN), both during rest and task-induced deactivation, throughout the adult lifespan. Data confirmed a decreased functional connectivity (FC) and task-induced deactivation of the DMN during the aging process and in subjects with lower mood; on the contrary, an increased FC was observed in subjects with higher perceived stress. Surprisingly, the association of aging with DMN was altered by stress and mood in specific regions. An increased difficulty to deactivate the DMN was noted in older participants with lower mood, contrasting with an increased deactivation in individuals presenting high stress, independently of their mood levels, with aging. Interestingly, this constant interaction across aging was globally most significant in the combination of high stress levels with a more depressed mood state, both during resting state and task-induced deactivations. The present results contribute to characterize the spectrum of FC and deactivation patterns of the DMN, highlighting the crucial association of stress and mood levels, during the adult aging process. These combinatorial approaches may help to understand the heterogeneity of the aging process in brain structure and function and several states that may lead to neuropsychiatric disorders.
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spelling The association between stress and mood across the adult lifespan on default mode networkAgingStressMoodDefault mode networkConnectivityCiências Médicas::Medicina BásicaScience & TechnologyAging of brain structure and function is a complex process characterized by high inter- and intra-individual variability. Such variability may arise from the interaction of multiple factors, including exposure to stressful experience and mood variation, across the lifespan. Using a multimodal neuroimaging and neurocognitive approach, we investigated the association of stress, mood and their interaction, in the structure and function of the default mode network (DMN), both during rest and task-induced deactivation, throughout the adult lifespan. Data confirmed a decreased functional connectivity (FC) and task-induced deactivation of the DMN during the aging process and in subjects with lower mood; on the contrary, an increased FC was observed in subjects with higher perceived stress. Surprisingly, the association of aging with DMN was altered by stress and mood in specific regions. An increased difficulty to deactivate the DMN was noted in older participants with lower mood, contrasting with an increased deactivation in individuals presenting high stress, independently of their mood levels, with aging. Interestingly, this constant interaction across aging was globally most significant in the combination of high stress levels with a more depressed mood state, both during resting state and task-induced deactivations. The present results contribute to characterize the spectrum of FC and deactivation patterns of the DMN, highlighting the crucial association of stress and mood levels, during the adult aging process. These combinatorial approaches may help to understand the heterogeneity of the aging process in brain structure and function and several states that may lead to neuropsychiatric disorders.The work was supported by SwitchBox-FP7-HEALTH-2010-Grant 259772-2 and by ON.2, O NOVO NORTE, North Portugal Regional Operational Programme 2007/2013, of the National strategic Reference Framework (NSRF) 2007/2013, through the European Regional Development Fund (ERDF)info:eu-repo/semantics/publishedVersionSpringer VerlagUniversidade do MinhoSoares, José Miguel MontenegroMarques, Paulo César GonçalvesMagalhães, Ricardo José SilvaSantos, Nadine CorreiaSousa, Nuno2017-01-112017-01-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49636engSoares, J. M., Marques, P., Magalhães, R., Santos, N. C., & Sousa, N. (2017). The association between stress and mood across the adult lifespan on default mode network. Brain Structure and Function, 222(1), 101-1121863-26531863-266110.1007/s00429-016-1203-326971253https://link.springer.com/article/10.1007/s00429-016-1203-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:12Zoai:repositorium.sdum.uminho.pt:1822/49636Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:13.776592Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The association between stress and mood across the adult lifespan on default mode network
title The association between stress and mood across the adult lifespan on default mode network
spellingShingle The association between stress and mood across the adult lifespan on default mode network
Soares, José Miguel Montenegro
Aging
Stress
Mood
Default mode network
Connectivity
Ciências Médicas::Medicina Básica
Science & Technology
title_short The association between stress and mood across the adult lifespan on default mode network
title_full The association between stress and mood across the adult lifespan on default mode network
title_fullStr The association between stress and mood across the adult lifespan on default mode network
title_full_unstemmed The association between stress and mood across the adult lifespan on default mode network
title_sort The association between stress and mood across the adult lifespan on default mode network
author Soares, José Miguel Montenegro
author_facet Soares, José Miguel Montenegro
Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
author_role author
author2 Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Soares, José Miguel Montenegro
Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
dc.subject.por.fl_str_mv Aging
Stress
Mood
Default mode network
Connectivity
Ciências Médicas::Medicina Básica
Science & Technology
topic Aging
Stress
Mood
Default mode network
Connectivity
Ciências Médicas::Medicina Básica
Science & Technology
description Aging of brain structure and function is a complex process characterized by high inter- and intra-individual variability. Such variability may arise from the interaction of multiple factors, including exposure to stressful experience and mood variation, across the lifespan. Using a multimodal neuroimaging and neurocognitive approach, we investigated the association of stress, mood and their interaction, in the structure and function of the default mode network (DMN), both during rest and task-induced deactivation, throughout the adult lifespan. Data confirmed a decreased functional connectivity (FC) and task-induced deactivation of the DMN during the aging process and in subjects with lower mood; on the contrary, an increased FC was observed in subjects with higher perceived stress. Surprisingly, the association of aging with DMN was altered by stress and mood in specific regions. An increased difficulty to deactivate the DMN was noted in older participants with lower mood, contrasting with an increased deactivation in individuals presenting high stress, independently of their mood levels, with aging. Interestingly, this constant interaction across aging was globally most significant in the combination of high stress levels with a more depressed mood state, both during resting state and task-induced deactivations. The present results contribute to characterize the spectrum of FC and deactivation patterns of the DMN, highlighting the crucial association of stress and mood levels, during the adult aging process. These combinatorial approaches may help to understand the heterogeneity of the aging process in brain structure and function and several states that may lead to neuropsychiatric disorders.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-11
2017-01-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/49636
url http://hdl.handle.net/1822/49636
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Soares, J. M., Marques, P., Magalhães, R., Santos, N. C., & Sousa, N. (2017). The association between stress and mood across the adult lifespan on default mode network. Brain Structure and Function, 222(1), 101-112
1863-2653
1863-2661
10.1007/s00429-016-1203-3
26971253
https://link.springer.com/article/10.1007/s00429-016-1203-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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