Endometriosis and cardiovascular disease: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Poeta Do Couto, Celina
Data de Publicação: 2023
Outros Autores: Policiano, Catarina, Pinto, Fausto J., Brito, Dulce, Caldeira, Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/57171
Resumo: © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
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spelling Endometriosis and cardiovascular disease: a systematic review and meta-analysisEndometriosisCardiovascular diseaseStrokeMyocardial infarctionSystematic reviewMeta-analysis© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/Objectives: Endometriosis is a benign, estrogen-dependent, chronic inflammatory disease and is the commonest cause of chronic pelvic pain in younger women. Cardiovascular disease is the main cause of death worldwide. Because the relationship between endometriosis and CV disease is not well established, we performed a systematic review of longitudinal studies that assessed the occurrence of cardiovascular events in women with endometriosis compared to those without endometriosis. Study design: Systematic review with meta-analysis of longitudinal cohort/nested case-control studies with endometriosis patients and controls. A search was conducted of the MEDLINE, CENTRAL, and Embase databases from inception to November 2022. Random-effects meta-analysis was performed to estimate pooled hazard ratios (HR) and 95 % confidence intervals (95%CI). Main outcome measure: Cardiovascular outcomes such as ischemic heart disease and cerebrovascular disease. Results: Six cohort studies were included, with a total of 254,929 participants. Meta-analysis showed that endometriosis was associated with a significantly increased risk of ischemic heart disease (HR 1.50, 95%CI 1.37–1.65; I 2 = 0 %) and cerebrovascular disease (HR 1.17, 95%CI 1.07–1.29; I 2 = 0 %). The one study that examined the relationship between cardiovascular mortality and endometriosis found a decreased risk in women with endometriosis relative to women without endometriosis (HR 0.55 (95%CI 0.47–0.65)). Conclusions: Endometriosis is associated with a significantly increased risk of cardiovascular disease, namely ischemic heart disease and cerebrovascular disease. Further studies are required to determine if endometriosis and/or its treatments are risk factors (particularly for cardiovascular mortality), and whether preventive measures could reduce the burden of cardiovascular disease in women with endometriosis. Study protocol registered at PROSPERO: CRD42022298830.ElsevierRepositório da Universidade de LisboaPoeta Do Couto, CelinaPoliciano, CatarinaPinto, Fausto J.Brito, DulceCaldeira, Daniel2023-04-18T11:18:26Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57171engMaturitas 171 (2023) 45–520378-512210.1016/j.maturitas.2023.04.0011873-4111info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:14Zoai:repositorio.ul.pt:10451/57171Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:36.921861Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Endometriosis and cardiovascular disease: a systematic review and meta-analysis
title Endometriosis and cardiovascular disease: a systematic review and meta-analysis
spellingShingle Endometriosis and cardiovascular disease: a systematic review and meta-analysis
Poeta Do Couto, Celina
Endometriosis
Cardiovascular disease
Stroke
Myocardial infarction
Systematic review
Meta-analysis
title_short Endometriosis and cardiovascular disease: a systematic review and meta-analysis
title_full Endometriosis and cardiovascular disease: a systematic review and meta-analysis
title_fullStr Endometriosis and cardiovascular disease: a systematic review and meta-analysis
title_full_unstemmed Endometriosis and cardiovascular disease: a systematic review and meta-analysis
title_sort Endometriosis and cardiovascular disease: a systematic review and meta-analysis
author Poeta Do Couto, Celina
author_facet Poeta Do Couto, Celina
Policiano, Catarina
Pinto, Fausto J.
Brito, Dulce
Caldeira, Daniel
author_role author
author2 Policiano, Catarina
Pinto, Fausto J.
Brito, Dulce
Caldeira, Daniel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Poeta Do Couto, Celina
Policiano, Catarina
Pinto, Fausto J.
Brito, Dulce
Caldeira, Daniel
dc.subject.por.fl_str_mv Endometriosis
Cardiovascular disease
Stroke
Myocardial infarction
Systematic review
Meta-analysis
topic Endometriosis
Cardiovascular disease
Stroke
Myocardial infarction
Systematic review
Meta-analysis
description © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
publishDate 2023
dc.date.none.fl_str_mv 2023-04-18T11:18:26Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57171
url http://hdl.handle.net/10451/57171
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Maturitas 171 (2023) 45–52
0378-5122
10.1016/j.maturitas.2023.04.001
1873-4111
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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