Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Detalhes bibliográficos
Autor(a) principal: Zhang, Quanchao
Data de Publicação: 2021
Outros Autores: He, Shan, Zhu, Xiangbo, Luo, Honglin, Gama, F. M., Peng, Mengxia, Deng, Xiaoyan, Wan, Yizao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/70260
Resumo: Supplementary data to this article can be found online at https://doi.org/10.1016/j.msec.2020.111861.
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spelling Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulationHeparinBacterial nanocelluloseVascular graftEndothelializationAnticoagulationScience & TechnologySupplementary data to this article can be found online at https://doi.org/10.1016/j.msec.2020.111861.Constructing biomimetic structure and immobilizing antithrombus factors are two effective methods to ensure rapid endothelialization and long-term anticoagulation for small-diameter vascular grafts. However, few literatures are available regarding simultaneous implementation of these two strategies. Herein, a nano-micro-fibrous biomimetic graft with a heparin coating was prepared via a step-by-step in situ biosynthesis method to improve potential endothelialization and anticoagulation. The 4-mm-diameter tubular graft consists of electrospun cellulose acetate (CA) microfibers and entangled bacterial nanocellulose (BNC) nanofibers with heparin coating on dual fibers. The hybridized and heparinized graft possesses suitable pore structure that facilitates endothelia cells adhesion and proliferation but prevents infiltration of fibrous tissue and blood leakage. In addition, it shows higher mechanical properties than those of bare CA and hybridized CA/BNC grafts, which match well with native blood vessels. Moreover, this dually modified graft exhibits improved blood compatibility and endothelialization over the counterparts without hybridization or heparinization according to the testing results of platelet adhesion, cell morphology, and protein expression of von Willebrand Factor. This novel graft with dual modifications shows promising as a new small-diameter vascular graft. This study provides a guidance for promoting endothelialization and blood compatibility by dual modifications of biomimetic structure and immobilized bioactive molecules.This work was supported by the National Natural Science Foundation of China (grant nos. 51973058 and 31870963), the Key Research and Development Program of Jiangxi Province (No. 20192ACB80008), and the Key Project of Natural Science Foundation of Jiangxi Province (20202ACBL204013).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoZhang, QuanchaoHe, ShanZhu, XiangboLuo, HonglinGama, F. M.Peng, MengxiaDeng, XiaoyanWan, Yizao2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/70260engZhang, Quanchao; He, Shan; Zhu, Xiangbo; Luo, Honglin; Gama, F. M.; Peng, Mengxia; Deng, Xiaoyan; Wan, Yizao, Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation. Materials Science and Engineering C-Materials for Biological Applications, 122(111861), 20210928-493110.1016/j.msec.2020.11186133641887111861http://www.journals.elsevier.com/materials-science-and-engineering-c/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:53Zoai:repositorium.sdum.uminho.pt:1822/70260Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:17.329081Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
title Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
spellingShingle Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
Zhang, Quanchao
Heparin
Bacterial nanocellulose
Vascular graft
Endothelialization
Anticoagulation
Science & Technology
title_short Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
title_full Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
title_fullStr Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
title_full_unstemmed Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
title_sort Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
author Zhang, Quanchao
author_facet Zhang, Quanchao
He, Shan
Zhu, Xiangbo
Luo, Honglin
Gama, F. M.
Peng, Mengxia
Deng, Xiaoyan
Wan, Yizao
author_role author
author2 He, Shan
Zhu, Xiangbo
Luo, Honglin
Gama, F. M.
Peng, Mengxia
Deng, Xiaoyan
Wan, Yizao
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Zhang, Quanchao
He, Shan
Zhu, Xiangbo
Luo, Honglin
Gama, F. M.
Peng, Mengxia
Deng, Xiaoyan
Wan, Yizao
dc.subject.por.fl_str_mv Heparin
Bacterial nanocellulose
Vascular graft
Endothelialization
Anticoagulation
Science & Technology
topic Heparin
Bacterial nanocellulose
Vascular graft
Endothelialization
Anticoagulation
Science & Technology
description Supplementary data to this article can be found online at https://doi.org/10.1016/j.msec.2020.111861.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
2021-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/70260
url http://hdl.handle.net/1822/70260
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Zhang, Quanchao; He, Shan; Zhu, Xiangbo; Luo, Honglin; Gama, F. M.; Peng, Mengxia; Deng, Xiaoyan; Wan, Yizao, Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation. Materials Science and Engineering C-Materials for Biological Applications, 122(111861), 2021
0928-4931
10.1016/j.msec.2020.111861
33641887
111861
http://www.journals.elsevier.com/materials-science-and-engineering-c/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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