Development of Fluorescent Chemosensors for Calcium and Lead Detection

Detalhes bibliográficos
Autor(a) principal: Gomes, Liliana J.
Data de Publicação: 2024
Outros Autores: Outis, Mani, Gomes, Clara S. B., Tomé, Augusto C., Moro, Artur J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163698
Resumo: This work was supported by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from FCT-MCTES (UIDB/50006/2020 and UIDP/50006/2020). L. J. G. acknowledges FCT-MCTES for a doctoral grant (UI/BD/153617/2022). The NMR spectrometers are part of Rede Nacional de RMN (PTNMR), supported by FCT-MCTES (grant ROTEIRO/0031/2013—PINFRA/22161/2016) (co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC). The X-ray infrastructure was financed by FCT-MCTES through project RECI/BBB-BEP/0124/2012. Publisher Copyright: © 2024 by the authors.
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spelling Development of Fluorescent Chemosensors for Calcium and Lead Detectionazacrownscalciumcoumarin-3-carboxamidesfluorescent chemosensorsleadmetal ion detectionAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistryThis work was supported by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from FCT-MCTES (UIDB/50006/2020 and UIDP/50006/2020). L. J. G. acknowledges FCT-MCTES for a doctoral grant (UI/BD/153617/2022). The NMR spectrometers are part of Rede Nacional de RMN (PTNMR), supported by FCT-MCTES (grant ROTEIRO/0031/2013—PINFRA/22161/2016) (co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC). The X-ray infrastructure was financed by FCT-MCTES through project RECI/BBB-BEP/0124/2012. Publisher Copyright: © 2024 by the authors.In the present work, several coumarin-3-carboxamides with different azacrown ether moieties were designed and tested as potential luminescent sensors for metal ions. The derivative containing a 1-aza-15-crown-5 as a metal chelating group was found to yield the strongest response for Ca2+ and Pb2+, exhibiting an eight- and nine-fold emission increase, respectively, while other cations induced no changes in the optical properties of the chemosensor molecule. Job’s plots revealed a 1:1 binding stoichiometry, with association constants of 4.8 × 104 and 8.7 × 104 M–1, and limits of detection of 1.21 and 8.04 µM, for Ca2+ and Pb2+, respectively. Computational studies suggest the existence of a PET quenching mechanism, which is inhibited after complexation with each of these two metals. Proton NMR experiments and X-ray crystallography suggest a contribution from the carbonyl groups in the coumarin-3-carboxamide fluorophore in the coordination sphere of the metal ion.DQ - Departamento de QuímicaLAQV@REQUIMTERUNGomes, Liliana J.Outis, ManiGomes, Clara S. B.Tomé, Augusto C.Moro, Artur J.2024-02-17T00:07:25Z2024-01-212024-01-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/163698eng1420-3049PURE: 82875274https://doi.org/10.3390/molecules29020527info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:18:33Zoai:run.unl.pt:10362/163698Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:18:33Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of Fluorescent Chemosensors for Calcium and Lead Detection
title Development of Fluorescent Chemosensors for Calcium and Lead Detection
spellingShingle Development of Fluorescent Chemosensors for Calcium and Lead Detection
Gomes, Liliana J.
azacrowns
calcium
coumarin-3-carboxamides
fluorescent chemosensors
lead
metal ion detection
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
title_short Development of Fluorescent Chemosensors for Calcium and Lead Detection
title_full Development of Fluorescent Chemosensors for Calcium and Lead Detection
title_fullStr Development of Fluorescent Chemosensors for Calcium and Lead Detection
title_full_unstemmed Development of Fluorescent Chemosensors for Calcium and Lead Detection
title_sort Development of Fluorescent Chemosensors for Calcium and Lead Detection
author Gomes, Liliana J.
author_facet Gomes, Liliana J.
Outis, Mani
Gomes, Clara S. B.
Tomé, Augusto C.
Moro, Artur J.
author_role author
author2 Outis, Mani
Gomes, Clara S. B.
Tomé, Augusto C.
Moro, Artur J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Gomes, Liliana J.
Outis, Mani
Gomes, Clara S. B.
Tomé, Augusto C.
Moro, Artur J.
dc.subject.por.fl_str_mv azacrowns
calcium
coumarin-3-carboxamides
fluorescent chemosensors
lead
metal ion detection
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
topic azacrowns
calcium
coumarin-3-carboxamides
fluorescent chemosensors
lead
metal ion detection
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
description This work was supported by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from FCT-MCTES (UIDB/50006/2020 and UIDP/50006/2020). L. J. G. acknowledges FCT-MCTES for a doctoral grant (UI/BD/153617/2022). The NMR spectrometers are part of Rede Nacional de RMN (PTNMR), supported by FCT-MCTES (grant ROTEIRO/0031/2013—PINFRA/22161/2016) (co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC). The X-ray infrastructure was financed by FCT-MCTES through project RECI/BBB-BEP/0124/2012. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-17T00:07:25Z
2024-01-21
2024-01-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163698
url http://hdl.handle.net/10362/163698
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
PURE: 82875274
https://doi.org/10.3390/molecules29020527
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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