Safety of Gold Nanoparticles
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/158546 |
Resumo: | Funding Information: The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT) for financial support through Projects UIDB/00645/2020, UIDB/04138/2020, UIDP/04138/2020, PTDC/BTM-MAT/31794/2017, and PTDC/QUI-QIN/0586/2020, as well as PhD fellowships SFRH/BD/148044/2019 and SFRH/BD/147306/2019. The authors are also thankful for the financial support to CESAM by FCT/MCTES (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020+UIDB/00100/2020) through national funds. Publisher Copyright: © 2023 by the authors. |
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Safety of Gold NanoparticlesFrom In Vitro to In Vivo Testing Array Checklistcancerex vivo modelsgold nanoparticlesin vitro modelsin vivo modelsnanomedicinenanotoxicologyPharmaceutical ScienceSDG 3 - Good Health and Well-beingFunding Information: The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT) for financial support through Projects UIDB/00645/2020, UIDB/04138/2020, UIDP/04138/2020, PTDC/BTM-MAT/31794/2017, and PTDC/QUI-QIN/0586/2020, as well as PhD fellowships SFRH/BD/148044/2019 and SFRH/BD/147306/2019. The authors are also thankful for the financial support to CESAM by FCT/MCTES (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020+UIDB/00100/2020) through national funds. Publisher Copyright: © 2023 by the authors.In recent years, gold nanoparticles (AuNPs) have aroused the interest of many researchers due to their unique physicochemical and optical properties. AuNPs are being explored in a variety of biomedical fields, either in diagnostics or therapy, particularly for localized thermal ablation of cancer cells after light irradiation. Besides the promising therapeutic potential of AuNPs, their safety constitutes a highly important issue for any medicine or medical device. For this reason, in the present work, the production and characterization of physicochemical properties and morphology of AuNPs coated with two different materials (hyaluronic and oleic acids (HAOA) and bovine serum albumin (BSA)) were firstly performed. Based on the above importantly referred issue, the in vitro safety of developed AuNPs was evaluated in healthy keratinocytes, human melanoma, breast, pancreatic and glioblastoma cancer cells, as well as in a three-dimensional human skin model. Ex vivo and in vivo biosafety assays using, respectively, human red blood cells and Artemia salina were also carried out. HAOA-AuNPs were selected for in vivo acute toxicity and biodistribution studies in healthy Balb/c mice. Histopathological analysis showed no significant signs of toxicity for the tested formulations. Overall, several techniques were developed in order to characterize the AuNPs and evaluate their safety. All these results support their use for biomedical applications.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNLopes, JoanaFerreira-Gonçalves, TâniaAscensão, LiaViana, Ana S.Carvalho, LinaCatarino, JoséFaísca, PedroOliva, Abelde Barros, Dragana P.C.Rodrigues, Cecília M.P.Gaspar, Maria ManuelaReis, Catarina Pinto2023-09-30T22:21:49Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158546eng1999-4923PURE: 72684792https://doi.org/10.3390/pharmaceutics15041120info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:41:06Zoai:run.unl.pt:10362/158546Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:12.397244Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Safety of Gold Nanoparticles From In Vitro to In Vivo Testing Array Checklist |
| title |
Safety of Gold Nanoparticles |
| spellingShingle |
Safety of Gold Nanoparticles Lopes, Joana cancer ex vivo models gold nanoparticles in vitro models in vivo models nanomedicine nanotoxicology Pharmaceutical Science SDG 3 - Good Health and Well-being |
| title_short |
Safety of Gold Nanoparticles |
| title_full |
Safety of Gold Nanoparticles |
| title_fullStr |
Safety of Gold Nanoparticles |
| title_full_unstemmed |
Safety of Gold Nanoparticles |
| title_sort |
Safety of Gold Nanoparticles |
| author |
Lopes, Joana |
| author_facet |
Lopes, Joana Ferreira-Gonçalves, Tânia Ascensão, Lia Viana, Ana S. Carvalho, Lina Catarino, José Faísca, Pedro Oliva, Abel de Barros, Dragana P.C. Rodrigues, Cecília M.P. Gaspar, Maria Manuela Reis, Catarina Pinto |
| author_role |
author |
| author2 |
Ferreira-Gonçalves, Tânia Ascensão, Lia Viana, Ana S. Carvalho, Lina Catarino, José Faísca, Pedro Oliva, Abel de Barros, Dragana P.C. Rodrigues, Cecília M.P. Gaspar, Maria Manuela Reis, Catarina Pinto |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Lopes, Joana Ferreira-Gonçalves, Tânia Ascensão, Lia Viana, Ana S. Carvalho, Lina Catarino, José Faísca, Pedro Oliva, Abel de Barros, Dragana P.C. Rodrigues, Cecília M.P. Gaspar, Maria Manuela Reis, Catarina Pinto |
| dc.subject.por.fl_str_mv |
cancer ex vivo models gold nanoparticles in vitro models in vivo models nanomedicine nanotoxicology Pharmaceutical Science SDG 3 - Good Health and Well-being |
| topic |
cancer ex vivo models gold nanoparticles in vitro models in vivo models nanomedicine nanotoxicology Pharmaceutical Science SDG 3 - Good Health and Well-being |
| description |
Funding Information: The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT) for financial support through Projects UIDB/00645/2020, UIDB/04138/2020, UIDP/04138/2020, PTDC/BTM-MAT/31794/2017, and PTDC/QUI-QIN/0586/2020, as well as PhD fellowships SFRH/BD/148044/2019 and SFRH/BD/147306/2019. The authors are also thankful for the financial support to CESAM by FCT/MCTES (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020+UIDB/00100/2020) through national funds. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-30T22:21:49Z 2023-04 2023-04-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/158546 |
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http://hdl.handle.net/10362/158546 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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1999-4923 PURE: 72684792 https://doi.org/10.3390/pharmaceutics15041120 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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RCAAP |
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