Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/114530 |
Resumo: | UIDB/04077/2020 |
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7160 |
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Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in miceCarrageenan-induced paw edemaColitisColorectal cancerInflammationInflammatory bowel diseasesSatureja hortensisSummer SavoryTNBS-induced colitisMaterials Science(all)InstrumentationEngineering(all)Process Chemistry and TechnologyComputer Science ApplicationsFluid Flow and Transfer ProcessesSDG 3 - Good Health and Well-beingUIDB/04077/2020Summer Savory (Satureja hortensis L.) is a plant traditionally used as a food spice in the Mediterranean region. Surprisingly, not much is known about the health beneficial effects of its phenolic-rich extracts. The majority of publications have always focused on the properties of their essential oil. One of the main phenolic compounds of Summer Savory is rosmarinic acid, which has demonstrated anti-inflammatory outcomes in several animal models of inflammatory-mediated diseases. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease, in addition to Ulcerative Colitis and Crohn’s Disease, frequently related with increased morbidity and even mortality due to the complications associated, including colorectal cancer. Our work has shown, to our knowledge, for the first time, that administration of a phenolic extract of Summer Savory in a mouse model of Ulcerative Colitis led to the reduction of several markers for intestinal injury, including reduction of inducible nitric oxide synthase (iNOS) and Cyclooxygenase-2 (COX-2 or prostaglandin-endoperoxide synthase) expression, two well-known mediators of tissue inflammation and progression to cancer and led also to a reduction of the mortality. Given the chemical constitution found in the extract and the preclinical evidence of a beneficial effect of polyphenols in inflammatory processes, an opportunity arises for pharmacological modulation of pathways relevant for IBD and progression to cancer with phenolic-rich extracts.MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosDCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)RUNRocha, JoãoLeandro, RaquelDireito, RosaGonçalves, MargaridaDuarte, Maria PaulaFernandes, AdelaideSepodes, BrunoFigueira, Maria Eduardo2021-03-26T23:26:47Z2020-12-012020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article19application/pdfhttp://hdl.handle.net/10362/114530eng2076-3417PURE: 27771100https://doi.org/10.3390/app10238465info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:51:28Zoai:run.unl.pt:10362/114530Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:51:28Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
title |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
spellingShingle |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice Rocha, João Carrageenan-induced paw edema Colitis Colorectal cancer Inflammation Inflammatory bowel diseases Satureja hortensis Summer Savory TNBS-induced colitis Materials Science(all) Instrumentation Engineering(all) Process Chemistry and Technology Computer Science Applications Fluid Flow and Transfer Processes SDG 3 - Good Health and Well-being |
title_short |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
title_full |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
title_fullStr |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
title_full_unstemmed |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
title_sort |
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice |
author |
Rocha, João |
author_facet |
Rocha, João Leandro, Raquel Direito, Rosa Gonçalves, Margarida Duarte, Maria Paula Fernandes, Adelaide Sepodes, Bruno Figueira, Maria Eduardo |
author_role |
author |
author2 |
Leandro, Raquel Direito, Rosa Gonçalves, Margarida Duarte, Maria Paula Fernandes, Adelaide Sepodes, Bruno Figueira, Maria Eduardo |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH) RUN |
dc.contributor.author.fl_str_mv |
Rocha, João Leandro, Raquel Direito, Rosa Gonçalves, Margarida Duarte, Maria Paula Fernandes, Adelaide Sepodes, Bruno Figueira, Maria Eduardo |
dc.subject.por.fl_str_mv |
Carrageenan-induced paw edema Colitis Colorectal cancer Inflammation Inflammatory bowel diseases Satureja hortensis Summer Savory TNBS-induced colitis Materials Science(all) Instrumentation Engineering(all) Process Chemistry and Technology Computer Science Applications Fluid Flow and Transfer Processes SDG 3 - Good Health and Well-being |
topic |
Carrageenan-induced paw edema Colitis Colorectal cancer Inflammation Inflammatory bowel diseases Satureja hortensis Summer Savory TNBS-induced colitis Materials Science(all) Instrumentation Engineering(all) Process Chemistry and Technology Computer Science Applications Fluid Flow and Transfer Processes SDG 3 - Good Health and Well-being |
description |
UIDB/04077/2020 |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 2020-12-01T00:00:00Z 2021-03-26T23:26:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/114530 |
url |
http://hdl.handle.net/10362/114530 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2076-3417 PURE: 27771100 https://doi.org/10.3390/app10238465 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
19 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545787162230784 |