Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/47457 https://doi.org/10.1080/09540121.2016.1191614 |
Resumo: | Cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections. However, in the context of HIV/HCV co-infection the research is more limited. The aim of this systematic review was to describe the characteristics of cognitive impairment in HIV/HCV co-infection and to examine the differences in cognitive performance between HIV/HCV and HIV and HCV mono-infected patients. Of the 437 records initially screened, 24 papers met the inclusion criteria and were included in the systematic review. Four studies were included in the meta-analysis. Most studies indicated that HIV/HCV co-infected patients had a higher level of cognitive impairment than HIV mono-infected patients. Meta-analysis also indicated that HIV mono-infected patients had a significantly lower global deficit score than co-infected patients. The results also indicated that co-infected patients were more likely to be impaired in information processing speed than HIV mono-infected patients. These findings can be challenged by biasing factors such as the small number of included studies, heterogeneity of the samples and a large diversity of methodological procedures. Future research with consistent and comprehensive neuropsychological batteries and covering a greater diversity of risk factors is needed, in order to clarify the effects of both viruses on cognitive function and the mechanisms that underlie these effects. Because cognitive impairments may pose significant challenges to medication adherence, quality of life and overall functioning, such knowledge may have important implications to the planning and implementation of effective interventions aimed at optimising the clinical management of these infections. |
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Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysisCognitive DysfunctionCoinfectionFemaleHIV InfectionsHepatitis C, ChronicHumansMaleMental ProcessesCognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections. However, in the context of HIV/HCV co-infection the research is more limited. The aim of this systematic review was to describe the characteristics of cognitive impairment in HIV/HCV co-infection and to examine the differences in cognitive performance between HIV/HCV and HIV and HCV mono-infected patients. Of the 437 records initially screened, 24 papers met the inclusion criteria and were included in the systematic review. Four studies were included in the meta-analysis. Most studies indicated that HIV/HCV co-infected patients had a higher level of cognitive impairment than HIV mono-infected patients. Meta-analysis also indicated that HIV mono-infected patients had a significantly lower global deficit score than co-infected patients. The results also indicated that co-infected patients were more likely to be impaired in information processing speed than HIV mono-infected patients. These findings can be challenged by biasing factors such as the small number of included studies, heterogeneity of the samples and a large diversity of methodological procedures. Future research with consistent and comprehensive neuropsychological batteries and covering a greater diversity of risk factors is needed, in order to clarify the effects of both viruses on cognitive function and the mechanisms that underlie these effects. Because cognitive impairments may pose significant challenges to medication adherence, quality of life and overall functioning, such knowledge may have important implications to the planning and implementation of effective interventions aimed at optimising the clinical management of these infections.2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/47457http://hdl.handle.net/10316/47457https://doi.org/10.1080/09540121.2016.1191614engFialho, R., Pereira, M., Bucur, M., Fisher, M., Whale, R., & Rusted, J. (2016). Cognitive impairment in HIV and HCV co-infected patients: A systematic review and meta-analysis. AIDS Care, 28(12), 1481-1494. doi:10.1080/09540121.2016.1191614http://www.tandfonline.com/doi/full/10.1080/09540121.2016.1191614Fialho, RenataPereira, MarcoBucur, MihaelaFisher, MartinWhale, RichardRusted, Jenniferinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T02:24:49Zoai:estudogeral.uc.pt:10316/47457Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:48:33.720037Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
title |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
spellingShingle |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis Fialho, Renata Cognitive Dysfunction Coinfection Female HIV Infections Hepatitis C, Chronic Humans Male Mental Processes |
title_short |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
title_full |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
title_fullStr |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
title_full_unstemmed |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
title_sort |
Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis |
author |
Fialho, Renata |
author_facet |
Fialho, Renata Pereira, Marco Bucur, Mihaela Fisher, Martin Whale, Richard Rusted, Jennifer |
author_role |
author |
author2 |
Pereira, Marco Bucur, Mihaela Fisher, Martin Whale, Richard Rusted, Jennifer |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Fialho, Renata Pereira, Marco Bucur, Mihaela Fisher, Martin Whale, Richard Rusted, Jennifer |
dc.subject.por.fl_str_mv |
Cognitive Dysfunction Coinfection Female HIV Infections Hepatitis C, Chronic Humans Male Mental Processes |
topic |
Cognitive Dysfunction Coinfection Female HIV Infections Hepatitis C, Chronic Humans Male Mental Processes |
description |
Cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections. However, in the context of HIV/HCV co-infection the research is more limited. The aim of this systematic review was to describe the characteristics of cognitive impairment in HIV/HCV co-infection and to examine the differences in cognitive performance between HIV/HCV and HIV and HCV mono-infected patients. Of the 437 records initially screened, 24 papers met the inclusion criteria and were included in the systematic review. Four studies were included in the meta-analysis. Most studies indicated that HIV/HCV co-infected patients had a higher level of cognitive impairment than HIV mono-infected patients. Meta-analysis also indicated that HIV mono-infected patients had a significantly lower global deficit score than co-infected patients. The results also indicated that co-infected patients were more likely to be impaired in information processing speed than HIV mono-infected patients. These findings can be challenged by biasing factors such as the small number of included studies, heterogeneity of the samples and a large diversity of methodological procedures. Future research with consistent and comprehensive neuropsychological batteries and covering a greater diversity of risk factors is needed, in order to clarify the effects of both viruses on cognitive function and the mechanisms that underlie these effects. Because cognitive impairments may pose significant challenges to medication adherence, quality of life and overall functioning, such knowledge may have important implications to the planning and implementation of effective interventions aimed at optimising the clinical management of these infections. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/47457 http://hdl.handle.net/10316/47457 https://doi.org/10.1080/09540121.2016.1191614 |
url |
http://hdl.handle.net/10316/47457 https://doi.org/10.1080/09540121.2016.1191614 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fialho, R., Pereira, M., Bucur, M., Fisher, M., Whale, R., & Rusted, J. (2016). Cognitive impairment in HIV and HCV co-infected patients: A systematic review and meta-analysis. AIDS Care, 28(12), 1481-1494. doi:10.1080/09540121.2016.1191614 http://www.tandfonline.com/doi/full/10.1080/09540121.2016.1191614 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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