New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/4649 |
Resumo: | Corneal tissue is the most commonly transplanted tissue worldwide. This work aimed to develop a new drug-eluting contact lens that may be used as a bandage after keratoprosthesis. During this work, films were produced using poly(vinyl alcohol) (PVA) and chitosan (CS) crosslinked with glyoxal (GL). Vancomycin chlorhydrate (VA) was impregnated in these systems by soaking. Attenuated total reflectance – Fourier transform infrared spectroscopy was used to confirm crosslinking. The cytotoxic and drug release profile, hydrophilicity, thermal and biodegradation as well as swelling capacity of the samples were assessed through in vitro studies. PVA and PVA/CS films were obtained by crosslinking with GL. The films were transparent, flexible with smooth surfaces, hydrophilic and able to load and release vancomycin for more than 8 h. Biodegradation in artificial lachrymal fluid (ALF) with lysozyme at 37 °C showed that mass loss was higher for the samples containing CS. Also, the samples prepared with CS showed the formation of pores which were visualized by SEM. All samples revealed a biocompatible character after 24 h in contact with cornea endothelial cells. As a general conclusion it was possible to determine that the 70PVA/30CS film showed to combine the necessary features to prepare vancomycin-eluting contact lenses to prevent inflammation after corneal substitution. |
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New drug-eluting lenses to be applied as bandages after keratoprosthesis implantationDrug-eluting lensKeratoprosthesisPoly(vinyl alcohol)ChitosanGlyoxalCorneal tissue is the most commonly transplanted tissue worldwide. This work aimed to develop a new drug-eluting contact lens that may be used as a bandage after keratoprosthesis. During this work, films were produced using poly(vinyl alcohol) (PVA) and chitosan (CS) crosslinked with glyoxal (GL). Vancomycin chlorhydrate (VA) was impregnated in these systems by soaking. Attenuated total reflectance – Fourier transform infrared spectroscopy was used to confirm crosslinking. The cytotoxic and drug release profile, hydrophilicity, thermal and biodegradation as well as swelling capacity of the samples were assessed through in vitro studies. PVA and PVA/CS films were obtained by crosslinking with GL. The films were transparent, flexible with smooth surfaces, hydrophilic and able to load and release vancomycin for more than 8 h. Biodegradation in artificial lachrymal fluid (ALF) with lysozyme at 37 °C showed that mass loss was higher for the samples containing CS. Also, the samples prepared with CS showed the formation of pores which were visualized by SEM. All samples revealed a biocompatible character after 24 h in contact with cornea endothelial cells. As a general conclusion it was possible to determine that the 70PVA/30CS film showed to combine the necessary features to prepare vancomycin-eluting contact lenses to prevent inflammation after corneal substitution.ElsevieruBibliorumCarreira, AnaFerreira, PaulaRibeiro, MP.Correia, Tiago R.Coutinho, Paula Isabel Teixeira GonçalvesCorreia, Ilídio Joaquim SobreiraGil, Maria2018-03-20T10:34:58Z2014-10-162014-10-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4649engCarreira, A.S., Ferreira, P., Ribeiro, M.P., Correia, T.R., Coutinho, P., Correia, I.J. e Gil M.H. (2014) “New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation”, International Journal of Pharmaceutics, Vol. 477 (1-2), pp. 218-22610.1016/j.ijpharm.2014.10.037metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:46Zoai:ubibliorum.ubi.pt:10400.6/4649Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:42.571139Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
title |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
spellingShingle |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation Carreira, Ana Drug-eluting lens Keratoprosthesis Poly(vinyl alcohol) Chitosan Glyoxal |
title_short |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
title_full |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
title_fullStr |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
title_full_unstemmed |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
title_sort |
New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation |
author |
Carreira, Ana |
author_facet |
Carreira, Ana Ferreira, Paula Ribeiro, MP. Correia, Tiago R. Coutinho, Paula Isabel Teixeira Gonçalves Correia, Ilídio Joaquim Sobreira Gil, Maria |
author_role |
author |
author2 |
Ferreira, Paula Ribeiro, MP. Correia, Tiago R. Coutinho, Paula Isabel Teixeira Gonçalves Correia, Ilídio Joaquim Sobreira Gil, Maria |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Carreira, Ana Ferreira, Paula Ribeiro, MP. Correia, Tiago R. Coutinho, Paula Isabel Teixeira Gonçalves Correia, Ilídio Joaquim Sobreira Gil, Maria |
dc.subject.por.fl_str_mv |
Drug-eluting lens Keratoprosthesis Poly(vinyl alcohol) Chitosan Glyoxal |
topic |
Drug-eluting lens Keratoprosthesis Poly(vinyl alcohol) Chitosan Glyoxal |
description |
Corneal tissue is the most commonly transplanted tissue worldwide. This work aimed to develop a new drug-eluting contact lens that may be used as a bandage after keratoprosthesis. During this work, films were produced using poly(vinyl alcohol) (PVA) and chitosan (CS) crosslinked with glyoxal (GL). Vancomycin chlorhydrate (VA) was impregnated in these systems by soaking. Attenuated total reflectance – Fourier transform infrared spectroscopy was used to confirm crosslinking. The cytotoxic and drug release profile, hydrophilicity, thermal and biodegradation as well as swelling capacity of the samples were assessed through in vitro studies. PVA and PVA/CS films were obtained by crosslinking with GL. The films were transparent, flexible with smooth surfaces, hydrophilic and able to load and release vancomycin for more than 8 h. Biodegradation in artificial lachrymal fluid (ALF) with lysozyme at 37 °C showed that mass loss was higher for the samples containing CS. Also, the samples prepared with CS showed the formation of pores which were visualized by SEM. All samples revealed a biocompatible character after 24 h in contact with cornea endothelial cells. As a general conclusion it was possible to determine that the 70PVA/30CS film showed to combine the necessary features to prepare vancomycin-eluting contact lenses to prevent inflammation after corneal substitution. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-16 2014-10-16T00:00:00Z 2018-03-20T10:34:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/4649 |
url |
http://hdl.handle.net/10400.6/4649 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carreira, A.S., Ferreira, P., Ribeiro, M.P., Correia, T.R., Coutinho, P., Correia, I.J. e Gil M.H. (2014) “New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation”, International Journal of Pharmaceutics, Vol. 477 (1-2), pp. 218-226 10.1016/j.ijpharm.2014.10.037 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136354450276352 |