Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial

Detalhes bibliográficos
Autor(a) principal: Ângelo, David
Data de Publicação: 2023
Outros Autores: Sanz, David, Maffia, Francesco, Cardoso, Henrique José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/57998
Resumo: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trialTemporomandibular disorderBotulinum toxinIncobotulinumtoxinATemporomandibular joint arthroscopy© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Background: Several studies have considered Botulinum Neurotoxin Type A injections effective in treating temporomandibular joint disorder (TMD) symptoms. A double-blind, randomized, controlled clinical trial investigated the benefit of complementary incobotulinumtoxinA (inco-BoNT/A) injections in the masticatory muscles of patients submitted to bilateral temporomandibular joint (TMJ) arthroscopy. Methods: Fifteen patients with TMD and an indication for bilateral TMJ arthroscopy were randomized into inco-BoNT/A (Xeomin, 100 U) or placebo groups (saline solution). Injections were carried out five days before TMJ arthroscopy. The primary outcome variable was a Visual Analogue Scale for TMJ arthralgia, and secondary outcomes were the myalgia degree, maximum mouth opening, and joint clicks. All outcome variables were assessed preoperatively (T0) and postoperatively (T1—week 5; T2—6-month follow-up). Results: At T1, the outcomes in the inco-BoNT/A group were improved, but not significantly more than in the placebo group. At T2, significant improvements in the TMJ arthralgia and myalgia scores were observed in the inco-BoNT/A group compared to the placebo. A higher number of postoperative reinterventions with further TMJ treatments were observed in the placebo group compared to inco-BoNT/A (63% vs. 14%). Conclusions: In patients submitted to TMJ arthroscopy, statistically significant long-term differences were observed between the placebo and inco-BoNT/A groups.MDPIRepositório da Universidade de LisboaÂngelo, DavidSanz, DavidMaffia, FrancescoCardoso, Henrique José2023-06-06T14:40:46Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57998engToxins 2023, 15(6), 37610.3390/toxins150603762072-6651info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:46Zoai:repositorio.ul.pt:10451/57998Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:23.725584Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
title Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
spellingShingle Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
Ângelo, David
Temporomandibular disorder
Botulinum toxin
IncobotulinumtoxinA
Temporomandibular joint arthroscopy
title_short Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
title_full Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
title_fullStr Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
title_full_unstemmed Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
title_sort Outcomes of IncobotulinumtoxinA injection on myalgia and arthralgia in patients undergoing temporomandibular joint arthroscopy: a randomized controlled trial
author Ângelo, David
author_facet Ângelo, David
Sanz, David
Maffia, Francesco
Cardoso, Henrique José
author_role author
author2 Sanz, David
Maffia, Francesco
Cardoso, Henrique José
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ângelo, David
Sanz, David
Maffia, Francesco
Cardoso, Henrique José
dc.subject.por.fl_str_mv Temporomandibular disorder
Botulinum toxin
IncobotulinumtoxinA
Temporomandibular joint arthroscopy
topic Temporomandibular disorder
Botulinum toxin
IncobotulinumtoxinA
Temporomandibular joint arthroscopy
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-06-06T14:40:46Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57998
url http://hdl.handle.net/10451/57998
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxins 2023, 15(6), 376
10.3390/toxins15060376
2072-6651
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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