A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid

Detalhes bibliográficos
Autor(a) principal: Teixeira, Sónia
Data de Publicação: 2019
Outros Autores: Santos, Miguel M., Ferraz, Ricardo, Prudêncio, Cristina, Fernandes, Maria H., Costa-Rodrigues, Joao, Branco, Luís C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14844
Resumo: Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.
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spelling A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic AcidNovel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.WileyRepositório Científico do Instituto Politécnico do PortoTeixeira, SóniaSantos, Miguel M.Ferraz, RicardoPrudêncio, CristinaFernandes, Maria H.Costa-Rodrigues, JoaoBranco, Luís C.2020-10-01T00:30:23Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14844engTeixeira, S., Santos, M. M., Ferraz, R., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues, J., & Branco, L. C. (2019). A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem, 14(20), 1767–1770. https://doi.org/10.1002/cmdc.20190039710.1002/cmdc.201900397info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:13Zoai:recipp.ipp.pt:10400.22/14844Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:38.518916Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
title A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
spellingShingle A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
Teixeira, Sónia
title_short A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
title_full A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
title_fullStr A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
title_full_unstemmed A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
title_sort A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
author Teixeira, Sónia
author_facet Teixeira, Sónia
Santos, Miguel M.
Ferraz, Ricardo
Prudêncio, Cristina
Fernandes, Maria H.
Costa-Rodrigues, Joao
Branco, Luís C.
author_role author
author2 Santos, Miguel M.
Ferraz, Ricardo
Prudêncio, Cristina
Fernandes, Maria H.
Costa-Rodrigues, Joao
Branco, Luís C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Teixeira, Sónia
Santos, Miguel M.
Ferraz, Ricardo
Prudêncio, Cristina
Fernandes, Maria H.
Costa-Rodrigues, Joao
Branco, Luís C.
description Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-10-01T00:30:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14844
url http://hdl.handle.net/10400.22/14844
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Teixeira, S., Santos, M. M., Ferraz, R., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues, J., & Branco, L. C. (2019). A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem, 14(20), 1767–1770. https://doi.org/10.1002/cmdc.201900397
10.1002/cmdc.201900397
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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