A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/14844 |
Resumo: | Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma. |
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A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic AcidNovel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.WileyRepositório Científico do Instituto Politécnico do PortoTeixeira, SóniaSantos, Miguel M.Ferraz, RicardoPrudêncio, CristinaFernandes, Maria H.Costa-Rodrigues, JoaoBranco, Luís C.2020-10-01T00:30:23Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14844engTeixeira, S., Santos, M. M., Ferraz, R., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues, J., & Branco, L. C. (2019). A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem, 14(20), 1767–1770. https://doi.org/10.1002/cmdc.20190039710.1002/cmdc.201900397info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:13Zoai:recipp.ipp.pt:10400.22/14844Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:38.518916Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
title |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
spellingShingle |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid Teixeira, Sónia |
title_short |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
title_full |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
title_fullStr |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
title_full_unstemmed |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
title_sort |
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
author |
Teixeira, Sónia |
author_facet |
Teixeira, Sónia Santos, Miguel M. Ferraz, Ricardo Prudêncio, Cristina Fernandes, Maria H. Costa-Rodrigues, Joao Branco, Luís C. |
author_role |
author |
author2 |
Santos, Miguel M. Ferraz, Ricardo Prudêncio, Cristina Fernandes, Maria H. Costa-Rodrigues, Joao Branco, Luís C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Teixeira, Sónia Santos, Miguel M. Ferraz, Ricardo Prudêncio, Cristina Fernandes, Maria H. Costa-Rodrigues, Joao Branco, Luís C. |
description |
Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2020-10-01T00:30:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/14844 |
url |
http://hdl.handle.net/10400.22/14844 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Teixeira, S., Santos, M. M., Ferraz, R., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues, J., & Branco, L. C. (2019). A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem, 14(20), 1767–1770. https://doi.org/10.1002/cmdc.201900397 10.1002/cmdc.201900397 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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