Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/17951 |
Resumo: | Hymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural origins. This study aimed to evaluate the anticancer properties of H. acida using human lung (H460), breast (MCF-7), and colon (HCT 116) cancer cell lines as well as the production, characterization, and cytotoxicity study of H. acida loaded into PLGA nanoparticles. Benchtop models of Saccharomyces cerevisiae and Raniceps ranninus were used for preliminary toxicity evaluation. Notable cytotoxic activity in benchtop models and human cancer cell lines was observed for H. acida crude extract. The PLGA nanoparticles loading H. acida had a size of about 200 nm and an association efficiency of above 60%, making them suitable to be delivered by different routes. The outcomes from this research showed that H. acida has anticancer activity as claimed from an ethnomedical point of view; however, a loss in activity was noted upon encapsulation, due to the sustained release of the drug. |
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Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticlesAnticancer activityCytotoxicityHymenocardia acidaNanoencapsulationNanoparticlePlant extractPLGAHymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural origins. This study aimed to evaluate the anticancer properties of H. acida using human lung (H460), breast (MCF-7), and colon (HCT 116) cancer cell lines as well as the production, characterization, and cytotoxicity study of H. acida loaded into PLGA nanoparticles. Benchtop models of Saccharomyces cerevisiae and Raniceps ranninus were used for preliminary toxicity evaluation. Notable cytotoxic activity in benchtop models and human cancer cell lines was observed for H. acida crude extract. The PLGA nanoparticles loading H. acida had a size of about 200 nm and an association efficiency of above 60%, making them suitable to be delivered by different routes. The outcomes from this research showed that H. acida has anticancer activity as claimed from an ethnomedical point of view; however, a loss in activity was noted upon encapsulation, due to the sustained release of the drug.MDPISapientiaAdedokun, OluwasegunNtungwe, Epole N.Viegas, CláudiaAdesina Ayinde, BunyaminBarboni, LucianoMaggi, FilippoSaraiva, LuciliaRijo, PatríciaFonte, Pedro2022-07-11T12:07:31Z2022-04-262022-05-27T13:36:46Z2022-04-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/17951engPharmaceuticals 15 (5): 535 (2022)10.3390/ph150505351424-8247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:30:04Zoai:sapientia.ualg.pt:10400.1/17951Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:07:43.247847Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
title |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
spellingShingle |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles Adedokun, Oluwasegun Anticancer activity Cytotoxicity Hymenocardia acida Nanoencapsulation Nanoparticle Plant extract PLGA |
title_short |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
title_full |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
title_fullStr |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
title_full_unstemmed |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
title_sort |
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded into PLGA nanoparticles |
author |
Adedokun, Oluwasegun |
author_facet |
Adedokun, Oluwasegun Ntungwe, Epole N. Viegas, Cláudia Adesina Ayinde, Bunyamin Barboni, Luciano Maggi, Filippo Saraiva, Lucilia Rijo, Patrícia Fonte, Pedro |
author_role |
author |
author2 |
Ntungwe, Epole N. Viegas, Cláudia Adesina Ayinde, Bunyamin Barboni, Luciano Maggi, Filippo Saraiva, Lucilia Rijo, Patrícia Fonte, Pedro |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Adedokun, Oluwasegun Ntungwe, Epole N. Viegas, Cláudia Adesina Ayinde, Bunyamin Barboni, Luciano Maggi, Filippo Saraiva, Lucilia Rijo, Patrícia Fonte, Pedro |
dc.subject.por.fl_str_mv |
Anticancer activity Cytotoxicity Hymenocardia acida Nanoencapsulation Nanoparticle Plant extract PLGA |
topic |
Anticancer activity Cytotoxicity Hymenocardia acida Nanoencapsulation Nanoparticle Plant extract PLGA |
description |
Hymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural origins. This study aimed to evaluate the anticancer properties of H. acida using human lung (H460), breast (MCF-7), and colon (HCT 116) cancer cell lines as well as the production, characterization, and cytotoxicity study of H. acida loaded into PLGA nanoparticles. Benchtop models of Saccharomyces cerevisiae and Raniceps ranninus were used for preliminary toxicity evaluation. Notable cytotoxic activity in benchtop models and human cancer cell lines was observed for H. acida crude extract. The PLGA nanoparticles loading H. acida had a size of about 200 nm and an association efficiency of above 60%, making them suitable to be delivered by different routes. The outcomes from this research showed that H. acida has anticancer activity as claimed from an ethnomedical point of view; however, a loss in activity was noted upon encapsulation, due to the sustained release of the drug. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-11T12:07:31Z 2022-04-26 2022-05-27T13:36:46Z 2022-04-26T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/17951 |
url |
http://hdl.handle.net/10400.1/17951 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceuticals 15 (5): 535 (2022) 10.3390/ph15050535 1424-8247 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133322668933120 |