Design of an Emulgel for Psoriasis Focused on Patient Preferences
Main Author: | |
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Publication Date: | 2022 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.22/22284 |
Summary: | Adherence to topical treatments is low and is known to be influenced by the vehicle properties. Betamethasone dipropionate (BD) is an anti-inflammatory steroid, used in psoriasis treatment in the form of an ointment, cream, or solution. The aim of this work was to develop a new vehicle for BD, focusing on the preferences of patients with psoriasis as a strategy to improve treatment adherence. Two vehicles with an aqueous external phase were explored: an emulgel and a hydrogel based on a cyclodextrin inclusion complex used to improve the aqueous solubility of BD. Since BD solubilization was not fully achieved in the hydrogel, only the emulgel was selected for further characterization. This new vehicle (emulgel) is characterized by its white, shiny appearance and good spreading properties. In comparison with petrolatum, a lower residue, higher evaporation rate, lower stickiness, and reduced ability to stain polyester fabric were observed. This vehicle also showed shear thinning behavior. The impact of this new vehicle on adherence to topical treatments should be further confirmed in clinical settings. |
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Design of an Emulgel for Psoriasis Focused on Patient PreferencesTopical vehiclesHydrogelEmulgelPsoriasisCyclodextrinsPatient-centric designMedication adherenceAdherence to topical treatments is low and is known to be influenced by the vehicle properties. Betamethasone dipropionate (BD) is an anti-inflammatory steroid, used in psoriasis treatment in the form of an ointment, cream, or solution. The aim of this work was to develop a new vehicle for BD, focusing on the preferences of patients with psoriasis as a strategy to improve treatment adherence. Two vehicles with an aqueous external phase were explored: an emulgel and a hydrogel based on a cyclodextrin inclusion complex used to improve the aqueous solubility of BD. Since BD solubilization was not fully achieved in the hydrogel, only the emulgel was selected for further characterization. This new vehicle (emulgel) is characterized by its white, shiny appearance and good spreading properties. In comparison with petrolatum, a lower residue, higher evaporation rate, lower stickiness, and reduced ability to stain polyester fabric were observed. This vehicle also showed shear thinning behavior. The impact of this new vehicle on adherence to topical treatments should be further confirmed in clinical settings.This work was financed by national funds under the project 47239-Cork2Cosmetic (NORTE-01-0247-FEDER-047239). S. Mota acknowledges the research fellowship (NORTE-01-0247-FEDER-047239), fully supported by national funding from project 47239-Cork2Cosmetic (NORTE-01-0247-FEDER-047239). This work was supported by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020, UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences-UCIBIO. The projects UIDB/00081/2020 and I LA/P/0056/2020 were funded by FCT/MCTES (PIDDAC).MDPIRepositório Científico do Instituto Politécnico do PortoOliveira, Rita Sanchesda Silva, Diva FerrazMota, SandraGarrido, JorgeGarrido, E. ManuelaLobo, José Manuel SousaAlmeida, Isabel Filipa2023-02-14T16:50:34Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/22284eng10.3390/app12073260info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:18:56Zoai:recipp.ipp.pt:10400.22/22284Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:42:20.929621Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
title |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
spellingShingle |
Design of an Emulgel for Psoriasis Focused on Patient Preferences Oliveira, Rita Sanches Topical vehicles Hydrogel Emulgel Psoriasis Cyclodextrins Patient-centric design Medication adherence |
title_short |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
title_full |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
title_fullStr |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
title_full_unstemmed |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
title_sort |
Design of an Emulgel for Psoriasis Focused on Patient Preferences |
author |
Oliveira, Rita Sanches |
author_facet |
Oliveira, Rita Sanches da Silva, Diva Ferraz Mota, Sandra Garrido, Jorge Garrido, E. Manuela Lobo, José Manuel Sousa Almeida, Isabel Filipa |
author_role |
author |
author2 |
da Silva, Diva Ferraz Mota, Sandra Garrido, Jorge Garrido, E. Manuela Lobo, José Manuel Sousa Almeida, Isabel Filipa |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Oliveira, Rita Sanches da Silva, Diva Ferraz Mota, Sandra Garrido, Jorge Garrido, E. Manuela Lobo, José Manuel Sousa Almeida, Isabel Filipa |
dc.subject.por.fl_str_mv |
Topical vehicles Hydrogel Emulgel Psoriasis Cyclodextrins Patient-centric design Medication adherence |
topic |
Topical vehicles Hydrogel Emulgel Psoriasis Cyclodextrins Patient-centric design Medication adherence |
description |
Adherence to topical treatments is low and is known to be influenced by the vehicle properties. Betamethasone dipropionate (BD) is an anti-inflammatory steroid, used in psoriasis treatment in the form of an ointment, cream, or solution. The aim of this work was to develop a new vehicle for BD, focusing on the preferences of patients with psoriasis as a strategy to improve treatment adherence. Two vehicles with an aqueous external phase were explored: an emulgel and a hydrogel based on a cyclodextrin inclusion complex used to improve the aqueous solubility of BD. Since BD solubilization was not fully achieved in the hydrogel, only the emulgel was selected for further characterization. This new vehicle (emulgel) is characterized by its white, shiny appearance and good spreading properties. In comparison with petrolatum, a lower residue, higher evaporation rate, lower stickiness, and reduced ability to stain polyester fabric were observed. This vehicle also showed shear thinning behavior. The impact of this new vehicle on adherence to topical treatments should be further confirmed in clinical settings. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-02-14T16:50:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/22284 |
url |
http://hdl.handle.net/10400.22/22284 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3390/app12073260 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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MDPI |
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MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131510045933568 |