Biomechanical performance of hybrid electrospun structures for skin regeneration

Detalhes bibliográficos
Autor(a) principal: Dias, J.R.
Data de Publicação: 2018
Outros Autores: Baptista-Silva, S., Sousa, A., Oliveira, A. L., Bártolo, P. J., Granja, P. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8541
Resumo: This study was supported by the Projects PTDC/BBB-ECT/2145/ 2014 and UID/Multi/04044/2013, financed by European Regional Development Fund (ERDF) through the Portuguese national programs Programa Operacional Factores de Competitividade (COMPETE), Portugal2020 and Norte2020, and by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This work is also supported by the research grants SFRH/BD/91104/2012 awarded to Juliana Dias and SFRH/BPD/90047/2012 awarded to Aureliana Sousa by FCT, and by the Investigator FCT program IF/00411/2013, awarded to Ana L. Oliveira. The authors thanks to CEMUP, University of Porto for the SEM images.
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spelling Biomechanical performance of hybrid electrospun structures for skin regenerationHybrid structuresElectrospun meshesWound dressingsECMSkin regenerationThis study was supported by the Projects PTDC/BBB-ECT/2145/ 2014 and UID/Multi/04044/2013, financed by European Regional Development Fund (ERDF) through the Portuguese national programs Programa Operacional Factores de Competitividade (COMPETE), Portugal2020 and Norte2020, and by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This work is also supported by the research grants SFRH/BD/91104/2012 awarded to Juliana Dias and SFRH/BPD/90047/2012 awarded to Aureliana Sousa by FCT, and by the Investigator FCT program IF/00411/2013, awarded to Ana L. Oliveira. The authors thanks to CEMUP, University of Porto for the SEM images.Wound dressings made by electrospun nanofibers have been demonstrating great potential to regenerate skin tissue as compared to the conventional membrane products available in the market. Until today most of the developed dressings have only demonstrated the capability to regenerate the dermis or epidermis. In this study we propose new hybrid electrospun meshes combining polycaprolactone and gelatin. Several approaches, multilayer, coating and blend were stablished to investigate the most appropriate hybrid structure with potential to promote skin regeneration in its full thickness. The structures were evaluated in terms of physico-chemical properties (porosity, water vapor permeability, contact angle and swelling degree) and according to its mechanical and biological performance. Multilayer and blend structures demonstrated to fit most of native skin requirements. However, looking to all the performed characterization we considered multilayer as the most promising hybrid structures, due its high porosity which contributed to an ideal water vapor permeability rate and good mechanical and biological properties. Based on this multilayer structure is a promisor wound dressing.ElsevierIC-OnlineDias, J.R.Baptista-Silva, S.Sousa, A.Oliveira, A. L.Bártolo, P. J.Granja, P. L.2023-05-31T10:11:39Z2018-082018-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8541engDias, J. R., Baptista-Silva, S., Sousa, A., Oliveira, A. L., Bártolo, P. J., & Granja, P. L. (2018). Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering C, 93, 816–827. https://doi.org/10.1016/j.msec.2018.08.0500928-493110.1016/j.msec.2018.08.050metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:34Zoai:iconline.ipleiria.pt:10400.8/8541Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:14.431577Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biomechanical performance of hybrid electrospun structures for skin regeneration
title Biomechanical performance of hybrid electrospun structures for skin regeneration
spellingShingle Biomechanical performance of hybrid electrospun structures for skin regeneration
Dias, J.R.
Hybrid structures
Electrospun meshes
Wound dressings
ECM
Skin regeneration
title_short Biomechanical performance of hybrid electrospun structures for skin regeneration
title_full Biomechanical performance of hybrid electrospun structures for skin regeneration
title_fullStr Biomechanical performance of hybrid electrospun structures for skin regeneration
title_full_unstemmed Biomechanical performance of hybrid electrospun structures for skin regeneration
title_sort Biomechanical performance of hybrid electrospun structures for skin regeneration
author Dias, J.R.
author_facet Dias, J.R.
Baptista-Silva, S.
Sousa, A.
Oliveira, A. L.
Bártolo, P. J.
Granja, P. L.
author_role author
author2 Baptista-Silva, S.
Sousa, A.
Oliveira, A. L.
Bártolo, P. J.
Granja, P. L.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Dias, J.R.
Baptista-Silva, S.
Sousa, A.
Oliveira, A. L.
Bártolo, P. J.
Granja, P. L.
dc.subject.por.fl_str_mv Hybrid structures
Electrospun meshes
Wound dressings
ECM
Skin regeneration
topic Hybrid structures
Electrospun meshes
Wound dressings
ECM
Skin regeneration
description This study was supported by the Projects PTDC/BBB-ECT/2145/ 2014 and UID/Multi/04044/2013, financed by European Regional Development Fund (ERDF) through the Portuguese national programs Programa Operacional Factores de Competitividade (COMPETE), Portugal2020 and Norte2020, and by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This work is also supported by the research grants SFRH/BD/91104/2012 awarded to Juliana Dias and SFRH/BPD/90047/2012 awarded to Aureliana Sousa by FCT, and by the Investigator FCT program IF/00411/2013, awarded to Ana L. Oliveira. The authors thanks to CEMUP, University of Porto for the SEM images.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
2018-08-01T00:00:00Z
2023-05-31T10:11:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8541
url http://hdl.handle.net/10400.8/8541
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dias, J. R., Baptista-Silva, S., Sousa, A., Oliveira, A. L., Bártolo, P. J., & Granja, P. L. (2018). Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering C, 93, 816–827. https://doi.org/10.1016/j.msec.2018.08.050
0928-4931
10.1016/j.msec.2018.08.050
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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