Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/6646 |
Resumo: | In Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal. The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease. The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20-69 years. No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon. Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs. Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs. 6%, P=0.003). Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies. |
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Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, PortugalHypercysteinemiaObesityAzoresPortugalCoronary Artery Disease (CAD)Doenças Cardio e Cérebro-vascularesAvaliação de RiscoIn Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal. The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease. The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20-69 years. No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon. Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs. Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs. 6%, P=0.003). Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies.)is work was supported by the Regional Government of the Azores (FRCT), Portugal (PhD grant number M3.1.2/F/017/ 2011 to AL, postdoctoral grant number M3.1.7/F/020/2011 to RF, and research project number M1.1.C/I/001/2016).HindawiRepositório Científico do Instituto Nacional de SaúdeLima, AnaFerin, RitaBourbon, MafaldaBaptista, JoséPavão, M. Leonor2020-05-11T08:13:04Z2019-06-202019-06-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6646engJ Nutr Metab. 2019 Jun 20;2019:1826780. doi: 10.1155/2019/1826780. eCollection 2019.2090-072410.1155/2019/1826780info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:47Zoai:repositorio.insa.pt:10400.18/6646Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:44.042244Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
title |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
spellingShingle |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal Lima, Ana Hypercysteinemia Obesity Azores Portugal Coronary Artery Disease (CAD) Doenças Cardio e Cérebro-vasculares Avaliação de Risco |
title_short |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
title_full |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
title_fullStr |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
title_full_unstemmed |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
title_sort |
Hypercysteinemia, a potential risk factor for central obesity and related disorders in Azores, Portugal |
author |
Lima, Ana |
author_facet |
Lima, Ana Ferin, Rita Bourbon, Mafalda Baptista, José Pavão, M. Leonor |
author_role |
author |
author2 |
Ferin, Rita Bourbon, Mafalda Baptista, José Pavão, M. Leonor |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Lima, Ana Ferin, Rita Bourbon, Mafalda Baptista, José Pavão, M. Leonor |
dc.subject.por.fl_str_mv |
Hypercysteinemia Obesity Azores Portugal Coronary Artery Disease (CAD) Doenças Cardio e Cérebro-vasculares Avaliação de Risco |
topic |
Hypercysteinemia Obesity Azores Portugal Coronary Artery Disease (CAD) Doenças Cardio e Cérebro-vasculares Avaliação de Risco |
description |
In Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal. The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease. The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20-69 years. No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon. Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs. Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs. 6%, P=0.003). Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-20 2019-06-20T00:00:00Z 2020-05-11T08:13:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6646 |
url |
http://hdl.handle.net/10400.18/6646 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Nutr Metab. 2019 Jun 20;2019:1826780. doi: 10.1155/2019/1826780. eCollection 2019. 2090-0724 10.1155/2019/1826780 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi |
publisher.none.fl_str_mv |
Hindawi |
dc.source.none.fl_str_mv |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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