Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/56510 |
Resumo: | Copyright © 2021 Larsen, Turicchi, Christensen, Larsen, Jørgensen, Mikkelsen, Horgan, O’Driscoll, Michalowska, Duarte, Scott, Santos, Encantado, Palmeira, Stubbs and Heitmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trialHair cortisolObesityStressWeight lossWeight loss maintenanceCopyright © 2021 Larsen, Turicchi, Christensen, Larsen, Jørgensen, Mikkelsen, Horgan, O’Driscoll, Michalowska, Duarte, Scott, Santos, Encantado, Palmeira, Stubbs and Heitmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Several cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P=0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability.The NoHoW study has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement number 643309). The present ancillary study was supported by the Danish Health Foundation (Helsefonden) (grant agreement number 20-B-0405). The Parker Institute is supported by a core grant from the Oak Foundation (grant agreement number OCAY-18-774-OFIL).FrontiersRepositório da Universidade de LisboaLarsen, Sofus C.Turicchi, JakeChristensen, Gitte L.Larsen, Charlotte S.Jørgensen, Niklas R.Mikkelsen, Marie-Louise K.Horgan, GrahamO’Driscoll, RuairiMichalowska, JoannaDuarte, CristianaScott, Sarah E.Santos, InêsEncantado, JorgePalmeira, António LabisaStubbs, R. JamesHeitmann, Berit L.2023-03-02T14:11:51Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56510engFront Endocrinol (Lausanne). 2021 Sep 29;12:65519710.3389/fendo.2021.6551971664-2392info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:08Zoai:repositorio.ul.pt:10451/56510Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:02.462265Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| title |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| spellingShingle |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial Larsen, Sofus C. Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| title_short |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| title_full |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| title_fullStr |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| title_full_unstemmed |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| title_sort |
Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial |
| author |
Larsen, Sofus C. |
| author_facet |
Larsen, Sofus C. Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O’Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, António Labisa Stubbs, R. James Heitmann, Berit L. |
| author_role |
author |
| author2 |
Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O’Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, António Labisa Stubbs, R. James Heitmann, Berit L. |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Larsen, Sofus C. Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O’Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, António Labisa Stubbs, R. James Heitmann, Berit L. |
| dc.subject.por.fl_str_mv |
Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| topic |
Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| description |
Copyright © 2021 Larsen, Turicchi, Christensen, Larsen, Jørgensen, Mikkelsen, Horgan, O’Driscoll, Michalowska, Duarte, Scott, Santos, Encantado, Palmeira, Stubbs and Heitmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-03-02T14:11:51Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/56510 |
| url |
http://hdl.handle.net/10451/56510 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Front Endocrinol (Lausanne). 2021 Sep 29;12:655197 10.3389/fendo.2021.655197 1664-2392 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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