Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

Detalhes bibliográficos
Autor(a) principal: Nuno Vale
Data de Publicação: 2008
Outros Autores: Margaret S Collins, Jiri Gut, Ricardo Ferraz, Philip J Rosenthal, Melanie T Cushionc, Rui Moreira, Paula Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/82118
Resumo: A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 mu g/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the mu M range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead compound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.
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spelling Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-onesQuímicaChemical sciencesA series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 mu g/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the mu M range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead compound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/82118eng0960-894X10.1016/j.bmcl.2007.11.105Nuno ValeMargaret S CollinsJiri GutRicardo FerrazPhilip J RosenthalMelanie T CushioncRui MoreiraPaula Gomesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:09:09Zoai:repositorio-aberto.up.pt:10216/82118Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:16:53.199420Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
title Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
spellingShingle Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
Nuno Vale
Química
Chemical sciences
title_short Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
title_full Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
title_fullStr Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
title_full_unstemmed Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
title_sort Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
author Nuno Vale
author_facet Nuno Vale
Margaret S Collins
Jiri Gut
Ricardo Ferraz
Philip J Rosenthal
Melanie T Cushionc
Rui Moreira
Paula Gomes
author_role author
author2 Margaret S Collins
Jiri Gut
Ricardo Ferraz
Philip J Rosenthal
Melanie T Cushionc
Rui Moreira
Paula Gomes
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nuno Vale
Margaret S Collins
Jiri Gut
Ricardo Ferraz
Philip J Rosenthal
Melanie T Cushionc
Rui Moreira
Paula Gomes
dc.subject.por.fl_str_mv Química
Chemical sciences
topic Química
Chemical sciences
description A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 mu g/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the mu M range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead compound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/82118
url https://hdl.handle.net/10216/82118
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0960-894X
10.1016/j.bmcl.2007.11.105
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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