An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/56891 |
Resumo: | Human culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared “predicted” genetic contributions to height from paleogenomic data and “achieved” adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (∼38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of −3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and −2.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals −2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory. |
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An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmersPaleogenomicsStature variationAgriculture transitionHealthHuman culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared “predicted” genetic contributions to height from paleogenomic data and “achieved” adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (∼38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of −3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and −2.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals −2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.National Academy of ScienceRepositório da Universidade de LisboaMarciniak, StephanieBergey, Christina M.Silva, Ana MariaHałuszko, AgataFurmanek, MirosławVeselka, BarbaraVelemínský, PetrVercellotti, GiuseppeWahl, JoachimZariņa, GunitaLonghi, CristinaKolář, JanGarrido-Pena, RafaelFlores-Fernández, RaúlHerrero-Corral, Ana M.Simalcsik, AngelaMüller, WernerSheridan, AlisonMiliauskienė, ŽydrūnėJankauskas, RimantasMoiseyev, VyacheslavKöhler, KittiKirály, ÁgnesGamarra, BeatrizCheronet, OliviaSzeverényi, VajkKiss, ViktóriaSzeniczey, TamásKiss, KrisztiánZoffmann, Zsuzsanna K.Koós, JuditHellebrandt, MagdolnaMaier, Robert M.Domboróczki, LászlóVirag, CristianNovak, MarioReich, DavidHajdu, Tamásvon Cramon-Taubadel, NoreenPinhasi, RonPerry, George H.2023-03-29T11:27:21Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56891engMarciniak, S., Bergey, C. M., Silva, A. M., Haluszko, A., Furmanek, M., Veselka, B., Veleminsky, P., Vercellotti, G., Wahl, J., Zarina, G., Longhi, C., Kolar, J., Garrido-Pena, R., Flores-Fernandez, R., Herrero-Corral, A. M., Simalcsik, A., Muller, W., Sheridan, A., Miliauskiene, Z., Jankauskas, R., Moiseyev, V., Kohler, K., Kiraly, A., Gamarra, B., Cheronet, O., Szeverenyi, V., Kiss, V., Szeniczey, T., Kiss, K., Zoffmann, Z. K., Koos, J., Hellebrandt, M., Maier, R. M., Domboroczki, L., Virag, C., Novak, M., Reich, D., Hajdu, T., von Cramon-Taubadel, N., Pinhasi, R., & Perry, G. H. (2022). An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers. Proc Natl Acad Sci U S A, 119(15) e2106743119. doi: 10.1073/pnas.21067431190027-8424https://doi.org/10.1073/pnas.21067431191091-6490info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:38Zoai:repositorio.ul.pt:10451/56891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:17.176915Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
title |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
spellingShingle |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers Marciniak, Stephanie Paleogenomics Stature variation Agriculture transition Health |
title_short |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
title_full |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
title_fullStr |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
title_full_unstemmed |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
title_sort |
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers |
author |
Marciniak, Stephanie |
author_facet |
Marciniak, Stephanie Bergey, Christina M. Silva, Ana Maria Hałuszko, Agata Furmanek, Mirosław Veselka, Barbara Velemínský, Petr Vercellotti, Giuseppe Wahl, Joachim Zariņa, Gunita Longhi, Cristina Kolář, Jan Garrido-Pena, Rafael Flores-Fernández, Raúl Herrero-Corral, Ana M. Simalcsik, Angela Müller, Werner Sheridan, Alison Miliauskienė, Žydrūnė Jankauskas, Rimantas Moiseyev, Vyacheslav Köhler, Kitti Király, Ágnes Gamarra, Beatriz Cheronet, Olivia Szeverényi, Vajk Kiss, Viktória Szeniczey, Tamás Kiss, Krisztián Zoffmann, Zsuzsanna K. Koós, Judit Hellebrandt, Magdolna Maier, Robert M. Domboróczki, László Virag, Cristian Novak, Mario Reich, David Hajdu, Tamás von Cramon-Taubadel, Noreen Pinhasi, Ron Perry, George H. |
author_role |
author |
author2 |
Bergey, Christina M. Silva, Ana Maria Hałuszko, Agata Furmanek, Mirosław Veselka, Barbara Velemínský, Petr Vercellotti, Giuseppe Wahl, Joachim Zariņa, Gunita Longhi, Cristina Kolář, Jan Garrido-Pena, Rafael Flores-Fernández, Raúl Herrero-Corral, Ana M. Simalcsik, Angela Müller, Werner Sheridan, Alison Miliauskienė, Žydrūnė Jankauskas, Rimantas Moiseyev, Vyacheslav Köhler, Kitti Király, Ágnes Gamarra, Beatriz Cheronet, Olivia Szeverényi, Vajk Kiss, Viktória Szeniczey, Tamás Kiss, Krisztián Zoffmann, Zsuzsanna K. Koós, Judit Hellebrandt, Magdolna Maier, Robert M. Domboróczki, László Virag, Cristian Novak, Mario Reich, David Hajdu, Tamás von Cramon-Taubadel, Noreen Pinhasi, Ron Perry, George H. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Marciniak, Stephanie Bergey, Christina M. Silva, Ana Maria Hałuszko, Agata Furmanek, Mirosław Veselka, Barbara Velemínský, Petr Vercellotti, Giuseppe Wahl, Joachim Zariņa, Gunita Longhi, Cristina Kolář, Jan Garrido-Pena, Rafael Flores-Fernández, Raúl Herrero-Corral, Ana M. Simalcsik, Angela Müller, Werner Sheridan, Alison Miliauskienė, Žydrūnė Jankauskas, Rimantas Moiseyev, Vyacheslav Köhler, Kitti Király, Ágnes Gamarra, Beatriz Cheronet, Olivia Szeverényi, Vajk Kiss, Viktória Szeniczey, Tamás Kiss, Krisztián Zoffmann, Zsuzsanna K. Koós, Judit Hellebrandt, Magdolna Maier, Robert M. Domboróczki, László Virag, Cristian Novak, Mario Reich, David Hajdu, Tamás von Cramon-Taubadel, Noreen Pinhasi, Ron Perry, George H. |
dc.subject.por.fl_str_mv |
Paleogenomics Stature variation Agriculture transition Health |
topic |
Paleogenomics Stature variation Agriculture transition Health |
description |
Human culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared “predicted” genetic contributions to height from paleogenomic data and “achieved” adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (∼38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of −3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and −2.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals −2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-03-29T11:27:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/56891 |
url |
http://hdl.handle.net/10451/56891 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marciniak, S., Bergey, C. M., Silva, A. M., Haluszko, A., Furmanek, M., Veselka, B., Veleminsky, P., Vercellotti, G., Wahl, J., Zarina, G., Longhi, C., Kolar, J., Garrido-Pena, R., Flores-Fernandez, R., Herrero-Corral, A. M., Simalcsik, A., Muller, W., Sheridan, A., Miliauskiene, Z., Jankauskas, R., Moiseyev, V., Kohler, K., Kiraly, A., Gamarra, B., Cheronet, O., Szeverenyi, V., Kiss, V., Szeniczey, T., Kiss, K., Zoffmann, Z. K., Koos, J., Hellebrandt, M., Maier, R. M., Domboroczki, L., Virag, C., Novak, M., Reich, D., Hajdu, T., von Cramon-Taubadel, N., Pinhasi, R., & Perry, G. H. (2022). An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers. Proc Natl Acad Sci U S A, 119(15) e2106743119. doi: 10.1073/pnas.2106743119 0027-8424 https://doi.org/10.1073/pnas.2106743119 1091-6490 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
National Academy of Science |
publisher.none.fl_str_mv |
National Academy of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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