Regulation of AMPA Receptors by Phosphorylation

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ana Luísa
Data de Publicação: 2000
Outros Autores: Duarte, Carlos B., Carvalho, Arsélio P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/7910
https://doi.org/10.1023/A:1007644128886
Resumo: The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions. Recent studies have shown that phosphorylation of AMPA receptors by cAMP-dependent protein kinase (PKA) and Ca2+ - and calmodulin-dependent protein kinase II (CaMKII) potentiates their activity, but phosphorylation of the receptor subunits may also affect their interaction with intracellular proteins, and their expression at the plasma membrane. Phosphorylation of AMPA receptor subunits has also been investigated in relation to processes of synaptic plasticity. This review focuses on recent advances in understanding the molecular mechanisms of regulation of AMPA receptors, and their implications in synaptic plasticity.
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spelling Regulation of AMPA Receptors by PhosphorylationThe AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions. Recent studies have shown that phosphorylation of AMPA receptors by cAMP-dependent protein kinase (PKA) and Ca2+ - and calmodulin-dependent protein kinase II (CaMKII) potentiates their activity, but phosphorylation of the receptor subunits may also affect their interaction with intracellular proteins, and their expression at the plasma membrane. Phosphorylation of AMPA receptor subunits has also been investigated in relation to processes of synaptic plasticity. This review focuses on recent advances in understanding the molecular mechanisms of regulation of AMPA receptors, and their implications in synaptic plasticity.2000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/7910http://hdl.handle.net/10316/7910https://doi.org/10.1023/A:1007644128886engNeurochemical Research. 25:9 (2000) 1245-1255Carvalho, Ana LuísaDuarte, Carlos B.Carvalho, Arsélio P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-29T09:41:53Zoai:estudogeral.uc.pt:10316/7910Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:33.951504Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Regulation of AMPA Receptors by Phosphorylation
title Regulation of AMPA Receptors by Phosphorylation
spellingShingle Regulation of AMPA Receptors by Phosphorylation
Carvalho, Ana Luísa
title_short Regulation of AMPA Receptors by Phosphorylation
title_full Regulation of AMPA Receptors by Phosphorylation
title_fullStr Regulation of AMPA Receptors by Phosphorylation
title_full_unstemmed Regulation of AMPA Receptors by Phosphorylation
title_sort Regulation of AMPA Receptors by Phosphorylation
author Carvalho, Ana Luísa
author_facet Carvalho, Ana Luísa
Duarte, Carlos B.
Carvalho, Arsélio P.
author_role author
author2 Duarte, Carlos B.
Carvalho, Arsélio P.
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Ana Luísa
Duarte, Carlos B.
Carvalho, Arsélio P.
description The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions. Recent studies have shown that phosphorylation of AMPA receptors by cAMP-dependent protein kinase (PKA) and Ca2+ - and calmodulin-dependent protein kinase II (CaMKII) potentiates their activity, but phosphorylation of the receptor subunits may also affect their interaction with intracellular proteins, and their expression at the plasma membrane. Phosphorylation of AMPA receptor subunits has also been investigated in relation to processes of synaptic plasticity. This review focuses on recent advances in understanding the molecular mechanisms of regulation of AMPA receptors, and their implications in synaptic plasticity.
publishDate 2000
dc.date.none.fl_str_mv 2000
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/7910
http://hdl.handle.net/10316/7910
https://doi.org/10.1023/A:1007644128886
url http://hdl.handle.net/10316/7910
https://doi.org/10.1023/A:1007644128886
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Neurochemical Research. 25:9 (2000) 1245-1255
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